Risk factors for severe COVID-19 infection in Brazilian children
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/234470 |
Resumo: | The aim of this study was to describe the epidemiological characteristics and clinical outcome of children hospitalized with COVID-19 and identify the risk factors for severe disease. All hospital admissions of pediatric patients between March and December 2020 in the southern region of Brazil were reviewed and the patients positive for RT-PCR for SARS-CoV-2 were identified. This region encompasses a population of over 2.8 million children and adolescents. Data were extracted from a national database that includes all cases of severe acute respiratory syndrome requiring hospitalization in Brazil. A total of 288 hospitalizations (51.3% female) with a median age of 3 years (interquartile range 0-12 years) were identified. Of these, 38.9% had chronic medical conditions, 55.6% required some form of supplementary oxygen, and 30.2% were admitted to an intensive care unit. There were 17 deaths (5.9%) related to COVID-19. Age less than 30 days was significantly associated with increased odds of critical illness (OR 9.52, 95% CI 3.01-30.08), as well as the presence of one chronic condition (OR 5.08 95% CI 2.78-9.33) or two or more chronic conditions (OR 6.60, 95% CI 3.17-13.74). Conclusion: Age under 30 days old and presence of chronic conditions were strongly associated with unfavorable outcomes in Brazilian children with SARS-CoV-2 infection. These findings could help local public health authorities to develop specific policies to protect this more vulnerable group of children. |
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Hendler, Jordana VazLago, Patricia Miranda doMüller, Gabriel CardozoSantana, Joao Carlos BatistaPiva, Jefferson PedroDaudt, Liane Esteves2022-01-27T04:30:12Z20211413-8670http://hdl.handle.net/10183/234470001135871The aim of this study was to describe the epidemiological characteristics and clinical outcome of children hospitalized with COVID-19 and identify the risk factors for severe disease. All hospital admissions of pediatric patients between March and December 2020 in the southern region of Brazil were reviewed and the patients positive for RT-PCR for SARS-CoV-2 were identified. This region encompasses a population of over 2.8 million children and adolescents. Data were extracted from a national database that includes all cases of severe acute respiratory syndrome requiring hospitalization in Brazil. A total of 288 hospitalizations (51.3% female) with a median age of 3 years (interquartile range 0-12 years) were identified. Of these, 38.9% had chronic medical conditions, 55.6% required some form of supplementary oxygen, and 30.2% were admitted to an intensive care unit. There were 17 deaths (5.9%) related to COVID-19. Age less than 30 days was significantly associated with increased odds of critical illness (OR 9.52, 95% CI 3.01-30.08), as well as the presence of one chronic condition (OR 5.08 95% CI 2.78-9.33) or two or more chronic conditions (OR 6.60, 95% CI 3.17-13.74). Conclusion: Age under 30 days old and presence of chronic conditions were strongly associated with unfavorable outcomes in Brazilian children with SARS-CoV-2 infection. These findings could help local public health authorities to develop specific policies to protect this more vulnerable group of children.application/pdfengThe Brazilian journal of infectious diseases. Salvador. Vol. 25, no. 6 (2021), 101650, 8 p.COVID-19Avaliação de resultados da assistência ao pacienteMortalidade hospitalarCriançaSARS-CoV-2Hospital outcomesHospital mortalityPediatric patientsRisk factors for severe COVID-19 infection in Brazilian childreninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001135871.pdf.txt001135871.pdf.txtExtracted Texttext/plain38846http://www.lume.ufrgs.br/bitstream/10183/234470/2/001135871.pdf.txtcf92c46b8976d5cc921ab33e048437f2MD52ORIGINAL001135871.pdfTexto completo (inglês)application/pdf343051http://www.lume.ufrgs.br/bitstream/10183/234470/1/001135871.pdf4e8c6e7c108c203279e764880d2f1934MD5110183/2344702022-12-18 05:46:52.277357oai:www.lume.ufrgs.br:10183/234470Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-12-18T07:46:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Risk factors for severe COVID-19 infection in Brazilian children |
title |
Risk factors for severe COVID-19 infection in Brazilian children |
spellingShingle |
Risk factors for severe COVID-19 infection in Brazilian children Hendler, Jordana Vaz COVID-19 Avaliação de resultados da assistência ao paciente Mortalidade hospitalar Criança SARS-CoV-2 Hospital outcomes Hospital mortality Pediatric patients |
title_short |
Risk factors for severe COVID-19 infection in Brazilian children |
title_full |
Risk factors for severe COVID-19 infection in Brazilian children |
title_fullStr |
Risk factors for severe COVID-19 infection in Brazilian children |
title_full_unstemmed |
Risk factors for severe COVID-19 infection in Brazilian children |
title_sort |
Risk factors for severe COVID-19 infection in Brazilian children |
author |
Hendler, Jordana Vaz |
author_facet |
Hendler, Jordana Vaz Lago, Patricia Miranda do Müller, Gabriel Cardozo Santana, Joao Carlos Batista Piva, Jefferson Pedro Daudt, Liane Esteves |
author_role |
author |
author2 |
Lago, Patricia Miranda do Müller, Gabriel Cardozo Santana, Joao Carlos Batista Piva, Jefferson Pedro Daudt, Liane Esteves |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Hendler, Jordana Vaz Lago, Patricia Miranda do Müller, Gabriel Cardozo Santana, Joao Carlos Batista Piva, Jefferson Pedro Daudt, Liane Esteves |
dc.subject.por.fl_str_mv |
COVID-19 Avaliação de resultados da assistência ao paciente Mortalidade hospitalar Criança SARS-CoV-2 |
topic |
COVID-19 Avaliação de resultados da assistência ao paciente Mortalidade hospitalar Criança SARS-CoV-2 Hospital outcomes Hospital mortality Pediatric patients |
dc.subject.eng.fl_str_mv |
Hospital outcomes Hospital mortality Pediatric patients |
description |
The aim of this study was to describe the epidemiological characteristics and clinical outcome of children hospitalized with COVID-19 and identify the risk factors for severe disease. All hospital admissions of pediatric patients between March and December 2020 in the southern region of Brazil were reviewed and the patients positive for RT-PCR for SARS-CoV-2 were identified. This region encompasses a population of over 2.8 million children and adolescents. Data were extracted from a national database that includes all cases of severe acute respiratory syndrome requiring hospitalization in Brazil. A total of 288 hospitalizations (51.3% female) with a median age of 3 years (interquartile range 0-12 years) were identified. Of these, 38.9% had chronic medical conditions, 55.6% required some form of supplementary oxygen, and 30.2% were admitted to an intensive care unit. There were 17 deaths (5.9%) related to COVID-19. Age less than 30 days was significantly associated with increased odds of critical illness (OR 9.52, 95% CI 3.01-30.08), as well as the presence of one chronic condition (OR 5.08 95% CI 2.78-9.33) or two or more chronic conditions (OR 6.60, 95% CI 3.17-13.74). Conclusion: Age under 30 days old and presence of chronic conditions were strongly associated with unfavorable outcomes in Brazilian children with SARS-CoV-2 infection. These findings could help local public health authorities to develop specific policies to protect this more vulnerable group of children. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
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2022-01-27T04:30:12Z |
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001135871 |
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The Brazilian journal of infectious diseases. Salvador. Vol. 25, no. 6 (2021), 101650, 8 p. |
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