Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/237104 |
Resumo: | Analogues of glucagon like peptide-1 (GLP-1) and other drugs that increase this peptide half-life are used worldwide in human medicine to treat type 2 diabetes mellitus (DM) and obesity. These molecules can increase insulin release and satiety, interesting effects that could also be useful in the treatment of domestic animals pathologies, however their use in veterinary medicine are still limited. Considering the increasing incidence of DM and obesity in cats and dogs, the aim of this review is to summarize the available information about the physiological and pharmacological actions of GLP-1 in domestic animals and discuss about its potential applications in veterinary medicine. In diabetic dogs, the use of drugs based on GLP-1 actions reduced blood glucose and increased glucose uptake, while in diabetic cats they reduced glycemic variability and exogenous insulin administration. Thus, available evidence indicates that GLP-1 based drugs could become alternatives to DM treatment in domestic animals. Nevertheless, current data do not provide enough elements to recommend these drugs widespread clinical use. |
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Model, Jorge Felipe ArgentaRocha, Débora SantosFagundes, Alessa da CostaVinagre, Anapaula Sommer2022-04-13T04:50:57Z20222451-943Xhttp://hdl.handle.net/10183/237104001139346Analogues of glucagon like peptide-1 (GLP-1) and other drugs that increase this peptide half-life are used worldwide in human medicine to treat type 2 diabetes mellitus (DM) and obesity. These molecules can increase insulin release and satiety, interesting effects that could also be useful in the treatment of domestic animals pathologies, however their use in veterinary medicine are still limited. Considering the increasing incidence of DM and obesity in cats and dogs, the aim of this review is to summarize the available information about the physiological and pharmacological actions of GLP-1 in domestic animals and discuss about its potential applications in veterinary medicine. In diabetic dogs, the use of drugs based on GLP-1 actions reduced blood glucose and increased glucose uptake, while in diabetic cats they reduced glycemic variability and exogenous insulin administration. Thus, available evidence indicates that GLP-1 based drugs could become alternatives to DM treatment in domestic animals. Nevertheless, current data do not provide enough elements to recommend these drugs widespread clinical use.application/pdfengVeterinary and animal science. [Amsterdam]. Vol. 16 (June 2022), 100245, 11 p.Peptídeo 1 semelhante ao glucagónDiabetes mellitusObesidadeAnimais de estimaçãoGatosCãesGLP-1CatsDogsDiabetes mellitusObesityIncretinPhysiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animalsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001139346.pdf.txt001139346.pdf.txtExtracted Texttext/plain71376http://www.lume.ufrgs.br/bitstream/10183/237104/2/001139346.pdf.txt5ba57f3519d1aabe7805b8bc01f1202aMD52ORIGINAL001139346.pdfTexto completo (inglês)application/pdf2878293http://www.lume.ufrgs.br/bitstream/10183/237104/1/001139346.pdf7acd93453c93d7ca339b49cf2d0df83cMD5110183/2371042022-04-20 04:48:43.566367oai:www.lume.ufrgs.br:10183/237104Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-04-20T07:48:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
title |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
spellingShingle |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals Model, Jorge Felipe Argenta Peptídeo 1 semelhante ao glucagón Diabetes mellitus Obesidade Animais de estimação Gatos Cães GLP-1 Cats Dogs Diabetes mellitus Obesity Incretin |
title_short |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
title_full |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
title_fullStr |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
title_full_unstemmed |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
title_sort |
Physiological and pharmacological actions of glucagon like peptide-1 (GLP-1) in domestic animals |
author |
Model, Jorge Felipe Argenta |
author_facet |
Model, Jorge Felipe Argenta Rocha, Débora Santos Fagundes, Alessa da Costa Vinagre, Anapaula Sommer |
author_role |
author |
author2 |
Rocha, Débora Santos Fagundes, Alessa da Costa Vinagre, Anapaula Sommer |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Model, Jorge Felipe Argenta Rocha, Débora Santos Fagundes, Alessa da Costa Vinagre, Anapaula Sommer |
dc.subject.por.fl_str_mv |
Peptídeo 1 semelhante ao glucagón Diabetes mellitus Obesidade Animais de estimação Gatos Cães |
topic |
Peptídeo 1 semelhante ao glucagón Diabetes mellitus Obesidade Animais de estimação Gatos Cães GLP-1 Cats Dogs Diabetes mellitus Obesity Incretin |
dc.subject.eng.fl_str_mv |
GLP-1 Cats Dogs Diabetes mellitus Obesity Incretin |
description |
Analogues of glucagon like peptide-1 (GLP-1) and other drugs that increase this peptide half-life are used worldwide in human medicine to treat type 2 diabetes mellitus (DM) and obesity. These molecules can increase insulin release and satiety, interesting effects that could also be useful in the treatment of domestic animals pathologies, however their use in veterinary medicine are still limited. Considering the increasing incidence of DM and obesity in cats and dogs, the aim of this review is to summarize the available information about the physiological and pharmacological actions of GLP-1 in domestic animals and discuss about its potential applications in veterinary medicine. In diabetic dogs, the use of drugs based on GLP-1 actions reduced blood glucose and increased glucose uptake, while in diabetic cats they reduced glycemic variability and exogenous insulin administration. Thus, available evidence indicates that GLP-1 based drugs could become alternatives to DM treatment in domestic animals. Nevertheless, current data do not provide enough elements to recommend these drugs widespread clinical use. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-04-13T04:50:57Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/237104 |
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2451-943X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001139346 |
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2451-943X 001139346 |
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http://hdl.handle.net/10183/237104 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Veterinary and animal science. [Amsterdam]. Vol. 16 (June 2022), 100245, 11 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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