Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/180807 |
Resumo: | Circulating levels of matrix metalloproteinase-2 (MMP-2) predict mortality and hospital admission in heart failure (HF) patients. However, the role of MMP-2 gene polymorphisms in the susceptibility and prognosis of HF remains elusive. In this study, 308 HF outpatients (216 Caucasian- and 92 African-Brazilians) and 333 healthy subjects (256 Caucasian- and 77 African- Brazilians) were genotyped for the -1575G>A (rs243866), -1059G>A (rs17859821), and -790G>T (rs243864) polymorphisms in the MMP-2 gene. Polymorphisms were analyzed individually and in combination (haplotype), and positive associations were adjusted for clinical covariates. Although allele frequencies were similar in HF patients and controls in both ethnic groups, homozygotes for the minor alleles were not found among African-Brazilian patients. After a median follow-up of 5.3 years, 124 patients (40.3%) died (54.8%of them for HF). In Caucasian-Brazilians, the TT genotype of the -790G>T polymorphism was associated with a decreased risk of HF-related death as compared with GT genotype (hazard ratio [HR] = 0.512, 95%confidence interval [CI] 0.285–0.920). However, this association was lost after adjusting for clinical covariates (HR = 0.703, 95%CI 0.365–1.353). Haplotype analysis revealed similar findings, as patients homozygous for the -1575G/-1059G/-790T haplotype had a lower rate of HF-related death than those with any other haplotype combination (12.9% versus 28.5%, respectively; P = 0.010). Again, this association did not remain after adjusting for clinical covariates (HR = 0.521, 95%CI 0.248–1.093). Our study does not exclude the possibility that polymorphisms inMMP-2 gene, particularly the -790G>T polymorphism, might be related to HF prognosis. However, due to the limitations of the study, our findings need to be confirmed in further larger studies. |
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Beber, Ana Rubia CostaPolina, Evelise ReginaBiolo, AndreiaSantos, Bruna L.Gomes, Daiane do CarmoLa Porta, Vanessa LaubertOlsen, Virgílio da RochaClausell, Nadine OliveiraRohde, Luis Eduardo PaimSantos, Kátia Gonçalves dos2018-07-31T02:33:18Z20161932-6203http://hdl.handle.net/10183/180807001072981Circulating levels of matrix metalloproteinase-2 (MMP-2) predict mortality and hospital admission in heart failure (HF) patients. However, the role of MMP-2 gene polymorphisms in the susceptibility and prognosis of HF remains elusive. In this study, 308 HF outpatients (216 Caucasian- and 92 African-Brazilians) and 333 healthy subjects (256 Caucasian- and 77 African- Brazilians) were genotyped for the -1575G>A (rs243866), -1059G>A (rs17859821), and -790G>T (rs243864) polymorphisms in the MMP-2 gene. Polymorphisms were analyzed individually and in combination (haplotype), and positive associations were adjusted for clinical covariates. Although allele frequencies were similar in HF patients and controls in both ethnic groups, homozygotes for the minor alleles were not found among African-Brazilian patients. After a median follow-up of 5.3 years, 124 patients (40.3%) died (54.8%of them for HF). In Caucasian-Brazilians, the TT genotype of the -790G>T polymorphism was associated with a decreased risk of HF-related death as compared with GT genotype (hazard ratio [HR] = 0.512, 95%confidence interval [CI] 0.285–0.920). However, this association was lost after adjusting for clinical covariates (HR = 0.703, 95%CI 0.365–1.353). Haplotype analysis revealed similar findings, as patients homozygous for the -1575G/-1059G/-790T haplotype had a lower rate of HF-related death than those with any other haplotype combination (12.9% versus 28.5%, respectively; P = 0.010). Again, this association did not remain after adjusting for clinical covariates (HR = 0.521, 95%CI 0.248–1.093). Our study does not exclude the possibility that polymorphisms inMMP-2 gene, particularly the -790G>T polymorphism, might be related to HF prognosis. However, due to the limitations of the study, our findings need to be confirmed in further larger studies.application/pdfengPLoS ONE. San Francisco. Vol. 11, no. 8 (Aug. 2016), e0161666, 15 p.BiomarcadoresInsuficiência cardíacaPredisposição genética para doençaFatores de riscoComorbidadePolimorfismo de nucleotídeo únicoMatrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survivalEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001072981.pdfTexto completo (inglês)application/pdf814832http://www.lume.ufrgs.br/bitstream/10183/180807/1/001072981.pdfbd3d8229e7cc3f9a7476e78f50fccef8MD51TEXT001072981.pdf.txt001072981.pdf.txtExtracted Texttext/plain51677http://www.lume.ufrgs.br/bitstream/10183/180807/2/001072981.pdf.txt2ac73ef0909b396bd43fca5ebf2b557cMD52THUMBNAIL001072981.pdf.jpg001072981.pdf.jpgGenerated Thumbnailimage/jpeg2014http://www.lume.ufrgs.br/bitstream/10183/180807/3/001072981.pdf.jpgefc0a5167761ccfebc9ece2b1338301cMD5310183/1808072023-09-23 03:33:52.437116oai:www.lume.ufrgs.br:10183/180807Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:33:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
title |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
spellingShingle |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival Beber, Ana Rubia Costa Biomarcadores Insuficiência cardíaca Predisposição genética para doença Fatores de risco Comorbidade Polimorfismo de nucleotídeo único |
title_short |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
title_full |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
title_fullStr |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
title_full_unstemmed |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
title_sort |
Matrix metalloproteinase-2 polymorphisms in chronic heart failure : relationship with susceptibility and long-term survival |
author |
Beber, Ana Rubia Costa |
author_facet |
Beber, Ana Rubia Costa Polina, Evelise Regina Biolo, Andreia Santos, Bruna L. Gomes, Daiane do Carmo La Porta, Vanessa Laubert Olsen, Virgílio da Rocha Clausell, Nadine Oliveira Rohde, Luis Eduardo Paim Santos, Kátia Gonçalves dos |
author_role |
author |
author2 |
Polina, Evelise Regina Biolo, Andreia Santos, Bruna L. Gomes, Daiane do Carmo La Porta, Vanessa Laubert Olsen, Virgílio da Rocha Clausell, Nadine Oliveira Rohde, Luis Eduardo Paim Santos, Kátia Gonçalves dos |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Beber, Ana Rubia Costa Polina, Evelise Regina Biolo, Andreia Santos, Bruna L. Gomes, Daiane do Carmo La Porta, Vanessa Laubert Olsen, Virgílio da Rocha Clausell, Nadine Oliveira Rohde, Luis Eduardo Paim Santos, Kátia Gonçalves dos |
dc.subject.por.fl_str_mv |
Biomarcadores Insuficiência cardíaca Predisposição genética para doença Fatores de risco Comorbidade Polimorfismo de nucleotídeo único |
topic |
Biomarcadores Insuficiência cardíaca Predisposição genética para doença Fatores de risco Comorbidade Polimorfismo de nucleotídeo único |
description |
Circulating levels of matrix metalloproteinase-2 (MMP-2) predict mortality and hospital admission in heart failure (HF) patients. However, the role of MMP-2 gene polymorphisms in the susceptibility and prognosis of HF remains elusive. In this study, 308 HF outpatients (216 Caucasian- and 92 African-Brazilians) and 333 healthy subjects (256 Caucasian- and 77 African- Brazilians) were genotyped for the -1575G>A (rs243866), -1059G>A (rs17859821), and -790G>T (rs243864) polymorphisms in the MMP-2 gene. Polymorphisms were analyzed individually and in combination (haplotype), and positive associations were adjusted for clinical covariates. Although allele frequencies were similar in HF patients and controls in both ethnic groups, homozygotes for the minor alleles were not found among African-Brazilian patients. After a median follow-up of 5.3 years, 124 patients (40.3%) died (54.8%of them for HF). In Caucasian-Brazilians, the TT genotype of the -790G>T polymorphism was associated with a decreased risk of HF-related death as compared with GT genotype (hazard ratio [HR] = 0.512, 95%confidence interval [CI] 0.285–0.920). However, this association was lost after adjusting for clinical covariates (HR = 0.703, 95%CI 0.365–1.353). Haplotype analysis revealed similar findings, as patients homozygous for the -1575G/-1059G/-790T haplotype had a lower rate of HF-related death than those with any other haplotype combination (12.9% versus 28.5%, respectively; P = 0.010). Again, this association did not remain after adjusting for clinical covariates (HR = 0.521, 95%CI 0.248–1.093). Our study does not exclude the possibility that polymorphisms inMMP-2 gene, particularly the -790G>T polymorphism, might be related to HF prognosis. However, due to the limitations of the study, our findings need to be confirmed in further larger studies. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-07-31T02:33:18Z |
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http://hdl.handle.net/10183/180807 |
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1932-6203 |
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001072981 |
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http://hdl.handle.net/10183/180807 |
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PLoS ONE. San Francisco. Vol. 11, no. 8 (Aug. 2016), e0161666, 15 p. |
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