Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats

Detalhes bibliográficos
Autor(a) principal: Puma, Enver Miguel Oruro
Data de Publicação: 2020
Outros Autores: Pardo, Grace Violeta Espinoza, Lucion, Aldo Bolten, Calcagnotto, Maria Elisa, Idiart, Marco Aurelio Pires
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/219788
Resumo: Studies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermotactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups younger than 10 postnatal days (P), but not older, rapidly induce an orientation-approximation behavior toward the conditioned odor in a two-choice preference test. The olfactory bulb (OB) and the anterior olfactory cortex (aPC), both modulated by norepinephrine (NE), have been identified as part of a neural circuit supporting this transitory olfactory learning. One possible explanation at the neuronal level for why the odor-stroke pairing induces consistent orientation-approximation behavior in <P10 pups, but not in >P10, is the coincident activation of prior existent neurons in the aPC mediating this behavior. Specifically, odorstroke conditioning in <P10 pups may activate more mother/nest odor’s responsive aPC neurons than in >P10 pups, promoting orientation-approximation behavior in the former but not in the latter. In order to test this hypothesis, we performed in vitro patch-clamp recordings of the aPC pyramidal neurons from rat pups from two age groups (P5–P8 and P14–P17) and built computational models for the OB-aPC neural circuit based on this physiological data. We conditioned the P5–P8 OB-aPC artificial circuit to an odor associated with NE activation (representing the process of maternal odor learning during mother–infant interactions inside the nest) and then evaluated the response of the OB-aPC circuit to the presentation of the conditioned odor. The results show that the number of responsive aPC neurons to the presentation of the conditioned odor in the P14–P17 OB-aPC circuit was lower than in the P5–P8 circuit, suggesting that at P14–P17, the reduced number of responsive neurons to the conditioned (maternal) odor might not be coincident with the responsive neurons for a second conditioned odor.
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spelling Puma, Enver Miguel OruroPardo, Grace Violeta EspinozaLucion, Aldo BoltenCalcagnotto, Maria ElisaIdiart, Marco Aurelio Pires2021-04-13T04:25:11Z20201072-0502http://hdl.handle.net/10183/219788001116619Studies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermotactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups younger than 10 postnatal days (P), but not older, rapidly induce an orientation-approximation behavior toward the conditioned odor in a two-choice preference test. The olfactory bulb (OB) and the anterior olfactory cortex (aPC), both modulated by norepinephrine (NE), have been identified as part of a neural circuit supporting this transitory olfactory learning. One possible explanation at the neuronal level for why the odor-stroke pairing induces consistent orientation-approximation behavior in <P10 pups, but not in >P10, is the coincident activation of prior existent neurons in the aPC mediating this behavior. Specifically, odorstroke conditioning in <P10 pups may activate more mother/nest odor’s responsive aPC neurons than in >P10 pups, promoting orientation-approximation behavior in the former but not in the latter. In order to test this hypothesis, we performed in vitro patch-clamp recordings of the aPC pyramidal neurons from rat pups from two age groups (P5–P8 and P14–P17) and built computational models for the OB-aPC neural circuit based on this physiological data. We conditioned the P5–P8 OB-aPC artificial circuit to an odor associated with NE activation (representing the process of maternal odor learning during mother–infant interactions inside the nest) and then evaluated the response of the OB-aPC circuit to the presentation of the conditioned odor. The results show that the number of responsive aPC neurons to the presentation of the conditioned odor in the P14–P17 OB-aPC circuit was lower than in the P5–P8 circuit, suggesting that at P14–P17, the reduced number of responsive neurons to the conditioned (maternal) odor might not be coincident with the responsive neurons for a second conditioned odor.application/pdfengLearning & memory. Cold Spring Harbor. Vol. 27, no. 1 (Jan. 2020), p. 20-32MemóriaPercepção olfatóriaCórtex olfatórioBulbo olfatórioMaturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in ratsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001116619.pdf.txt001116619.pdf.txtExtracted Texttext/plain75763http://www.lume.ufrgs.br/bitstream/10183/219788/2/001116619.pdf.txt959410312bfd8b8f1d7e30a348e4c084MD52ORIGINAL001116619.pdfTexto completo (inglês)application/pdf9118150http://www.lume.ufrgs.br/bitstream/10183/219788/1/001116619.pdf3eb14d837698a2e5349c3699de487360MD5110183/2197882023-10-28 03:33:07.498027oai:www.lume.ufrgs.br:10183/219788Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-28T06:33:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
title Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
spellingShingle Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
Puma, Enver Miguel Oruro
Memória
Percepção olfatória
Córtex olfatório
Bulbo olfatório
title_short Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
title_full Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
title_fullStr Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
title_full_unstemmed Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
title_sort Maturation of pyramidal cells in anterior piriform cortex may be sufficient to explain the end of early olfactory learning in rats
author Puma, Enver Miguel Oruro
author_facet Puma, Enver Miguel Oruro
Pardo, Grace Violeta Espinoza
Lucion, Aldo Bolten
Calcagnotto, Maria Elisa
Idiart, Marco Aurelio Pires
author_role author
author2 Pardo, Grace Violeta Espinoza
Lucion, Aldo Bolten
Calcagnotto, Maria Elisa
Idiart, Marco Aurelio Pires
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Puma, Enver Miguel Oruro
Pardo, Grace Violeta Espinoza
Lucion, Aldo Bolten
Calcagnotto, Maria Elisa
Idiart, Marco Aurelio Pires
dc.subject.por.fl_str_mv Memória
Percepção olfatória
Córtex olfatório
Bulbo olfatório
topic Memória
Percepção olfatória
Córtex olfatório
Bulbo olfatório
description Studies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermotactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups younger than 10 postnatal days (P), but not older, rapidly induce an orientation-approximation behavior toward the conditioned odor in a two-choice preference test. The olfactory bulb (OB) and the anterior olfactory cortex (aPC), both modulated by norepinephrine (NE), have been identified as part of a neural circuit supporting this transitory olfactory learning. One possible explanation at the neuronal level for why the odor-stroke pairing induces consistent orientation-approximation behavior in <P10 pups, but not in >P10, is the coincident activation of prior existent neurons in the aPC mediating this behavior. Specifically, odorstroke conditioning in <P10 pups may activate more mother/nest odor’s responsive aPC neurons than in >P10 pups, promoting orientation-approximation behavior in the former but not in the latter. In order to test this hypothesis, we performed in vitro patch-clamp recordings of the aPC pyramidal neurons from rat pups from two age groups (P5–P8 and P14–P17) and built computational models for the OB-aPC neural circuit based on this physiological data. We conditioned the P5–P8 OB-aPC artificial circuit to an odor associated with NE activation (representing the process of maternal odor learning during mother–infant interactions inside the nest) and then evaluated the response of the OB-aPC circuit to the presentation of the conditioned odor. The results show that the number of responsive aPC neurons to the presentation of the conditioned odor in the P14–P17 OB-aPC circuit was lower than in the P5–P8 circuit, suggesting that at P14–P17, the reduced number of responsive neurons to the conditioned (maternal) odor might not be coincident with the responsive neurons for a second conditioned odor.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-04-13T04:25:11Z
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dc.relation.ispartof.pt_BR.fl_str_mv Learning & memory. Cold Spring Harbor. Vol. 27, no. 1 (Jan. 2020), p. 20-32
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