The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225799 |
Resumo: | Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. ,e aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance. |
id |
UFRGS-2_bd1afb97d7a6d87dc1f51cd1f59e982c |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/225799 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Quatrin, AndréiaConte, LisianeSilva, Dariane Trivisiol daFigueiredo, Cassiele GSomacal, SabrinaRoehrs, MiguelTeixeira, Cibele FerreiraBarbisan, FernandaAugusti, Paula RossiniMaróstica Júnior, MárioCruz, Ivana Beatrici Manica daEmanuelli, Tatiana2021-08-18T04:31:37Z20182090-0724http://hdl.handle.net/10183/225799001074100Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. ,e aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.application/pdfengJournal of Nutrition and Metabolism. London. Vol. 2018, ID 9794629, 13 p.JabuticabaDiabetes mellitusCompostos bioativosCarotenóideThe hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001074100.pdf.txt001074100.pdf.txtExtracted Texttext/plain60508http://www.lume.ufrgs.br/bitstream/10183/225799/2/001074100.pdf.txtd45843c3b7a7f0a01eac1d1ead524f6dMD52ORIGINAL001074100.pdfTexto completo (inglês)application/pdf1717135http://www.lume.ufrgs.br/bitstream/10183/225799/1/001074100.pdf8596e34ad3bf8c80f8ded54367bf5e7fMD5110183/2257992023-05-17 03:27:14.072557oai:www.lume.ufrgs.br:10183/225799Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-17T06:27:14Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
title |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
spellingShingle |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis Quatrin, Andréia Jabuticaba Diabetes mellitus Compostos bioativos Carotenóide |
title_short |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
title_full |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
title_fullStr |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
title_full_unstemmed |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
title_sort |
The hepatoprotective effect of jaboticaba peel powder in a rat model of type 2 Diabetes Mellitus involves the modulation of thiol/disulfide redox state through the upregulation of glutathione synthesis |
author |
Quatrin, Andréia |
author_facet |
Quatrin, Andréia Conte, Lisiane Silva, Dariane Trivisiol da Figueiredo, Cassiele G Somacal, Sabrina Roehrs, Miguel Teixeira, Cibele Ferreira Barbisan, Fernanda Augusti, Paula Rossini Maróstica Júnior, Mário Cruz, Ivana Beatrici Manica da Emanuelli, Tatiana |
author_role |
author |
author2 |
Conte, Lisiane Silva, Dariane Trivisiol da Figueiredo, Cassiele G Somacal, Sabrina Roehrs, Miguel Teixeira, Cibele Ferreira Barbisan, Fernanda Augusti, Paula Rossini Maróstica Júnior, Mário Cruz, Ivana Beatrici Manica da Emanuelli, Tatiana |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Quatrin, Andréia Conte, Lisiane Silva, Dariane Trivisiol da Figueiredo, Cassiele G Somacal, Sabrina Roehrs, Miguel Teixeira, Cibele Ferreira Barbisan, Fernanda Augusti, Paula Rossini Maróstica Júnior, Mário Cruz, Ivana Beatrici Manica da Emanuelli, Tatiana |
dc.subject.por.fl_str_mv |
Jabuticaba Diabetes mellitus Compostos bioativos Carotenóide |
topic |
Jabuticaba Diabetes mellitus Compostos bioativos Carotenóide |
description |
Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. ,e aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2021-08-18T04:31:37Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/225799 |
dc.identifier.issn.pt_BR.fl_str_mv |
2090-0724 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001074100 |
identifier_str_mv |
2090-0724 001074100 |
url |
http://hdl.handle.net/10183/225799 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Nutrition and Metabolism. London. Vol. 2018, ID 9794629, 13 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/225799/2/001074100.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/225799/1/001074100.pdf |
bitstream.checksum.fl_str_mv |
d45843c3b7a7f0a01eac1d1ead524f6d 8596e34ad3bf8c80f8ded54367bf5e7f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1792790454746480640 |