Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/181496 |
Resumo: | Background: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. Methods: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. Results: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. Conclusion: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia. |
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Spanemberg, LucasCaldieraro, Marco Antonio KnobVares, Edgar ArruaAguiar, Bianca Wollenhaupt deKauer-Sant'Anna, MárciaKawamoto, Sheila YuriGalvão, EmilyParker, GordonFleck, Marcelo Pio de Almeida2018-08-28T02:29:22Z20141178-2021http://hdl.handle.net/10183/181496000964772Background: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. Methods: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. Results: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. Conclusion: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia.application/pdfengNeuropsychiatric disease and treatment. Auckland. Vol. 10 (2014), p. 1523-1531DepressãoEstresse oxidativoCitocinasFator neurotrófico derivado do encéfaloBrain-derived neurotrophic factorMelancholic depressionInflammatory cytokinesOxidative stressBiological differences between melancholic and nonmelancholic depression subtyped by the CORE measureEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000964772.pdfTexto completo (inglês)application/pdf266666http://www.lume.ufrgs.br/bitstream/10183/181496/1/000964772.pdfda02721c737d2df5e044776f8e30fc79MD51TEXT000964772.pdf.txt000964772.pdf.txtExtracted Texttext/plain47267http://www.lume.ufrgs.br/bitstream/10183/181496/2/000964772.pdf.txtaf9f2ccfe8b8d6cd32a2001abdc6b814MD52THUMBNAIL000964772.pdf.jpg000964772.pdf.jpgGenerated Thumbnailimage/jpeg2007http://www.lume.ufrgs.br/bitstream/10183/181496/3/000964772.pdf.jpg1c3369157c6ca5308445cd96bdf9b4d8MD5310183/1814962023-04-13 03:26:38.576324oai:www.lume.ufrgs.br:10183/181496Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-04-13T06:26:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
title |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
spellingShingle |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure Spanemberg, Lucas Depressão Estresse oxidativo Citocinas Fator neurotrófico derivado do encéfalo Brain-derived neurotrophic factor Melancholic depression Inflammatory cytokines Oxidative stress |
title_short |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
title_full |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
title_fullStr |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
title_full_unstemmed |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
title_sort |
Biological differences between melancholic and nonmelancholic depression subtyped by the CORE measure |
author |
Spanemberg, Lucas |
author_facet |
Spanemberg, Lucas Caldieraro, Marco Antonio Knob Vares, Edgar Arrua Aguiar, Bianca Wollenhaupt de Kauer-Sant'Anna, Márcia Kawamoto, Sheila Yuri Galvão, Emily Parker, Gordon Fleck, Marcelo Pio de Almeida |
author_role |
author |
author2 |
Caldieraro, Marco Antonio Knob Vares, Edgar Arrua Aguiar, Bianca Wollenhaupt de Kauer-Sant'Anna, Márcia Kawamoto, Sheila Yuri Galvão, Emily Parker, Gordon Fleck, Marcelo Pio de Almeida |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Spanemberg, Lucas Caldieraro, Marco Antonio Knob Vares, Edgar Arrua Aguiar, Bianca Wollenhaupt de Kauer-Sant'Anna, Márcia Kawamoto, Sheila Yuri Galvão, Emily Parker, Gordon Fleck, Marcelo Pio de Almeida |
dc.subject.por.fl_str_mv |
Depressão Estresse oxidativo Citocinas Fator neurotrófico derivado do encéfalo |
topic |
Depressão Estresse oxidativo Citocinas Fator neurotrófico derivado do encéfalo Brain-derived neurotrophic factor Melancholic depression Inflammatory cytokines Oxidative stress |
dc.subject.eng.fl_str_mv |
Brain-derived neurotrophic factor Melancholic depression Inflammatory cytokines Oxidative stress |
description |
Background: The purpose of this study was to compare melancholic patients rated by the CORE measure of observable psychomotor disturbance with nonmelancholic and control subjects across a set of biomarkers. Methods: Depressed patients were classified as melancholic or nonmelancholic by using the CORE measure. Both groups of patients, as well as control subjects, were compared for a set of clinical and laboratory measures. Serum levels of brain-derived neurotrophic factor, of two markers of oxidative stress (protein carbonyl content [PCC] and thiobarbituric acid reactive substances [TBARS]), and of several immunity markers (interleukin [IL]-2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor-alpha, and interferon-gamma) were analyzed. Results: Thirty-three depressed patients and 54 healthy controls were studied. Depressive patients showed higher IL-4, IL-6, and PCC values than healthy controls. Thirteen (39%) of the depressed patients were assigned as melancholic by the CORE measure. They generated lower interferon-gamma (compared with nonmelancholic depressed patients) and TBARS (compared with both the nonmelancholic subset and controls) and returned higher IL-6 levels than controls. Both depressive groups generated higher PCC scores than controls, with no difference between melancholic and nonmelancholic subsets. Conclusion: A sign-based measure to rate melancholia was able to replicate and extend biological findings discriminating melancholic depression. Signs of psychomotor disturbance may be a useful diagnostic measure of melancholia. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2018-08-28T02:29:22Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/181496 |
dc.identifier.issn.pt_BR.fl_str_mv |
1178-2021 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000964772 |
identifier_str_mv |
1178-2021 000964772 |
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http://hdl.handle.net/10183/181496 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Neuropsychiatric disease and treatment. Auckland. Vol. 10 (2014), p. 1523-1531 |
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openAccess |
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