Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons
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Publication Date: | 2012 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/87817 |
Summary: | After a brief review of the most recent findings in the study of human evolution, an extensive comparison of the complete genomes of our nearest relative, the chimpanzee (Pan troglodytes), of extant Homo sapiens, archaic Homo neanderthalensis and the Denisova specimen were made. The focus was on non-synonymous mutations, which consequently had an impact on protein levels and these changes were classified according to degree of effect. A total of 10,447 non-synonymous substitutions were found in which the derived allele is fixed or nearly fixed in humans as compared to chimpanzee. Their most frequent location was on chromosome 21. Their presence was then searched in the two archaic genomes. Mutations in 381 genes would imply radical amino acid changes, with a fraction of these related to olfaction and other important physiological processes. Eight new alleles were identified in the Neanderthal and/or Denisova genetic pools. Four others, possibly affecting cognition, occured both in the sapiens and two other archaic genomes. The selective sweep that gave rise to Homo sapiens could, therefore, have initiated before the modern/archaic human divergence. |
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Paixão Côrtes, Vanessa RodriguesViscardi, Lucas HenriquesSalzano, Francisco MauroHunemeier, TábitaBortolini, Maria Cátira2014-02-27T01:50:54Z20121415-4757http://hdl.handle.net/10183/87817000871249After a brief review of the most recent findings in the study of human evolution, an extensive comparison of the complete genomes of our nearest relative, the chimpanzee (Pan troglodytes), of extant Homo sapiens, archaic Homo neanderthalensis and the Denisova specimen were made. The focus was on non-synonymous mutations, which consequently had an impact on protein levels and these changes were classified according to degree of effect. A total of 10,447 non-synonymous substitutions were found in which the derived allele is fixed or nearly fixed in humans as compared to chimpanzee. Their most frequent location was on chromosome 21. Their presence was then searched in the two archaic genomes. Mutations in 381 genes would imply radical amino acid changes, with a fraction of these related to olfaction and other important physiological processes. Eight new alleles were identified in the Neanderthal and/or Denisova genetic pools. Four others, possibly affecting cognition, occured both in the sapiens and two other archaic genomes. The selective sweep that gave rise to Homo sapiens could, therefore, have initiated before the modern/archaic human divergence.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 904-911Evolução humanaGenômicaSeleção naturalHomo sapiensNeandertalDenisovahuman evolutioncomparative genomicspositive selectionNeanderthalDenisovaHomo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisonsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000871249.pdf000871249.pdfTexto completo (inglês)application/pdf559977http://www.lume.ufrgs.br/bitstream/10183/87817/1/000871249.pdf3921ae549e5fd116670b3efc467c8bd6MD51TEXT000871249.pdf.txt000871249.pdf.txtExtracted Texttext/plain47911http://www.lume.ufrgs.br/bitstream/10183/87817/2/000871249.pdf.txt9d09485b060eca3551590b642997f5d3MD52THUMBNAIL000871249.pdf.jpg000871249.pdf.jpgGenerated Thumbnailimage/jpeg1870http://www.lume.ufrgs.br/bitstream/10183/87817/3/000871249.pdf.jpgac239646a1cfb74a0c80778aa4e0c815MD5310183/878172021-07-09 04:34:21.643708oai:www.lume.ufrgs.br:10183/87817Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:34:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
title |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
spellingShingle |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons Paixão Côrtes, Vanessa Rodrigues Evolução humana Genômica Seleção natural Homo sapiens Neandertal Denisova human evolution comparative genomics positive selection Neanderthal Denisova |
title_short |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
title_full |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
title_fullStr |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
title_full_unstemmed |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
title_sort |
Homo sapiens, Homo neanderthalensis and the Denisova specimen : New insights on their evolutionary histories using whole-genome comparisons |
author |
Paixão Côrtes, Vanessa Rodrigues |
author_facet |
Paixão Côrtes, Vanessa Rodrigues Viscardi, Lucas Henriques Salzano, Francisco Mauro Hunemeier, Tábita Bortolini, Maria Cátira |
author_role |
author |
author2 |
Viscardi, Lucas Henriques Salzano, Francisco Mauro Hunemeier, Tábita Bortolini, Maria Cátira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Paixão Côrtes, Vanessa Rodrigues Viscardi, Lucas Henriques Salzano, Francisco Mauro Hunemeier, Tábita Bortolini, Maria Cátira |
dc.subject.por.fl_str_mv |
Evolução humana Genômica Seleção natural Homo sapiens Neandertal Denisova |
topic |
Evolução humana Genômica Seleção natural Homo sapiens Neandertal Denisova human evolution comparative genomics positive selection Neanderthal Denisova |
dc.subject.eng.fl_str_mv |
human evolution comparative genomics positive selection Neanderthal Denisova |
description |
After a brief review of the most recent findings in the study of human evolution, an extensive comparison of the complete genomes of our nearest relative, the chimpanzee (Pan troglodytes), of extant Homo sapiens, archaic Homo neanderthalensis and the Denisova specimen were made. The focus was on non-synonymous mutations, which consequently had an impact on protein levels and these changes were classified according to degree of effect. A total of 10,447 non-synonymous substitutions were found in which the derived allele is fixed or nearly fixed in humans as compared to chimpanzee. Their most frequent location was on chromosome 21. Their presence was then searched in the two archaic genomes. Mutations in 381 genes would imply radical amino acid changes, with a fraction of these related to olfaction and other important physiological processes. Eight new alleles were identified in the Neanderthal and/or Denisova genetic pools. Four others, possibly affecting cognition, occured both in the sapiens and two other archaic genomes. The selective sweep that gave rise to Homo sapiens could, therefore, have initiated before the modern/archaic human divergence. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2014-02-27T01:50:54Z |
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1415-4757 |
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000871249 |
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language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 904-911 |
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