Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/262877 |
Resumo: | Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking. |
id |
UFRGS-2_c48b082f45c45648bff91a2c66031d0b |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/262877 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Moura, Helena FerreiraHansen, FernandaGalland, Fabiana Andrea BarreraSilvelo, DaianeRebelatto, Fernando PezziniOrnell, FelipeMassuda, RaffaelScherer, Juliana NichterwitzSchuch, Felipe BarretoKessler, Felix Henrique PaimDiemen, Lisia von2023-08-01T03:32:58Z20221516-4446http://hdl.handle.net/10183/262877001171322Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 44, no. 5 (2022), p. 548-556.InflamaçãoTranstornos relacionados ao uso de álcoolCitocinasRevisão sistemáticaMetanáliseAlcoholBiomarkerInflammationInterleukinsIL-6Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001171322.pdf.txt001171322.pdf.txtExtracted Texttext/plain40291http://www.lume.ufrgs.br/bitstream/10183/262877/2/001171322.pdf.txt61ae772775596f7d235b8dee02707802MD52ORIGINAL001171322.pdfTexto completo (inglês)application/pdf196792http://www.lume.ufrgs.br/bitstream/10183/262877/1/001171322.pdff612c22ae9ace51c2ed50fb087efa332MD5110183/2628772023-08-02 03:31:33.061597oai:www.lume.ufrgs.br:10183/262877Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-02T06:31:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
title |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
spellingShingle |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis Moura, Helena Ferreira Inflamação Transtornos relacionados ao uso de álcool Citocinas Revisão sistemática Metanálise Alcohol Biomarker Inflammation Interleukins IL-6 |
title_short |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
title_full |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
title_fullStr |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
title_full_unstemmed |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
title_sort |
Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis |
author |
Moura, Helena Ferreira |
author_facet |
Moura, Helena Ferreira Hansen, Fernanda Galland, Fabiana Andrea Barrera Silvelo, Daiane Rebelatto, Fernando Pezzini Ornell, Felipe Massuda, Raffael Scherer, Juliana Nichterwitz Schuch, Felipe Barreto Kessler, Felix Henrique Paim Diemen, Lisia von |
author_role |
author |
author2 |
Hansen, Fernanda Galland, Fabiana Andrea Barrera Silvelo, Daiane Rebelatto, Fernando Pezzini Ornell, Felipe Massuda, Raffael Scherer, Juliana Nichterwitz Schuch, Felipe Barreto Kessler, Felix Henrique Paim Diemen, Lisia von |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Moura, Helena Ferreira Hansen, Fernanda Galland, Fabiana Andrea Barrera Silvelo, Daiane Rebelatto, Fernando Pezzini Ornell, Felipe Massuda, Raffael Scherer, Juliana Nichterwitz Schuch, Felipe Barreto Kessler, Felix Henrique Paim Diemen, Lisia von |
dc.subject.por.fl_str_mv |
Inflamação Transtornos relacionados ao uso de álcool Citocinas Revisão sistemática Metanálise |
topic |
Inflamação Transtornos relacionados ao uso de álcool Citocinas Revisão sistemática Metanálise Alcohol Biomarker Inflammation Interleukins IL-6 |
dc.subject.eng.fl_str_mv |
Alcohol Biomarker Inflammation Interleukins IL-6 |
description |
Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-08-01T03:32:58Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/262877 |
dc.identifier.issn.pt_BR.fl_str_mv |
1516-4446 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001171322 |
identifier_str_mv |
1516-4446 001171322 |
url |
http://hdl.handle.net/10183/262877 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de psiquiatria (1999). São Paulo. Vol. 44, no. 5 (2022), p. 548-556. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/262877/2/001171322.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/262877/1/001171322.pdf |
bitstream.checksum.fl_str_mv |
61ae772775596f7d235b8dee02707802 f612c22ae9ace51c2ed50fb087efa332 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1815447833286803456 |