Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Moura, Helena Ferreira
Data de Publicação: 2022
Outros Autores: Hansen, Fernanda, Galland, Fabiana Andrea Barrera, Silvelo, Daiane, Rebelatto, Fernando Pezzini, Ornell, Felipe, Massuda, Raffael, Scherer, Juliana Nichterwitz, Schuch, Felipe Barreto, Kessler, Felix Henrique Paim, Diemen, Lisia von
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/262877
Resumo: Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking.
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spelling Moura, Helena FerreiraHansen, FernandaGalland, Fabiana Andrea BarreraSilvelo, DaianeRebelatto, Fernando PezziniOrnell, FelipeMassuda, RaffaelScherer, Juliana NichterwitzSchuch, Felipe BarretoKessler, Felix Henrique PaimDiemen, Lisia von2023-08-01T03:32:58Z20221516-4446http://hdl.handle.net/10183/262877001171322Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 44, no. 5 (2022), p. 548-556.InflamaçãoTranstornos relacionados ao uso de álcoolCitocinasRevisão sistemáticaMetanáliseAlcoholBiomarkerInflammationInterleukinsIL-6Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001171322.pdf.txt001171322.pdf.txtExtracted Texttext/plain40291http://www.lume.ufrgs.br/bitstream/10183/262877/2/001171322.pdf.txt61ae772775596f7d235b8dee02707802MD52ORIGINAL001171322.pdfTexto completo (inglês)application/pdf196792http://www.lume.ufrgs.br/bitstream/10183/262877/1/001171322.pdff612c22ae9ace51c2ed50fb087efa332MD5110183/2628772023-08-02 03:31:33.061597oai:www.lume.ufrgs.br:10183/262877Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-02T06:31:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
title Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
spellingShingle Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
Moura, Helena Ferreira
Inflamação
Transtornos relacionados ao uso de álcool
Citocinas
Revisão sistemática
Metanálise
Alcohol
Biomarker
Inflammation
Interleukins
IL-6
title_short Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
title_full Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
title_fullStr Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
title_full_unstemmed Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
title_sort Inflammatory cytokines and alcohol use disorder : systematic review and meta-analysis
author Moura, Helena Ferreira
author_facet Moura, Helena Ferreira
Hansen, Fernanda
Galland, Fabiana Andrea Barrera
Silvelo, Daiane
Rebelatto, Fernando Pezzini
Ornell, Felipe
Massuda, Raffael
Scherer, Juliana Nichterwitz
Schuch, Felipe Barreto
Kessler, Felix Henrique Paim
Diemen, Lisia von
author_role author
author2 Hansen, Fernanda
Galland, Fabiana Andrea Barrera
Silvelo, Daiane
Rebelatto, Fernando Pezzini
Ornell, Felipe
Massuda, Raffael
Scherer, Juliana Nichterwitz
Schuch, Felipe Barreto
Kessler, Felix Henrique Paim
Diemen, Lisia von
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Helena Ferreira
Hansen, Fernanda
Galland, Fabiana Andrea Barrera
Silvelo, Daiane
Rebelatto, Fernando Pezzini
Ornell, Felipe
Massuda, Raffael
Scherer, Juliana Nichterwitz
Schuch, Felipe Barreto
Kessler, Felix Henrique Paim
Diemen, Lisia von
dc.subject.por.fl_str_mv Inflamação
Transtornos relacionados ao uso de álcool
Citocinas
Revisão sistemática
Metanálise
topic Inflamação
Transtornos relacionados ao uso de álcool
Citocinas
Revisão sistemática
Metanálise
Alcohol
Biomarker
Inflammation
Interleukins
IL-6
dc.subject.eng.fl_str_mv Alcohol
Biomarker
Inflammation
Interleukins
IL-6
description Objective: To assess differences in blood inflammatory cytokines between people with alcohol use disorder (AUD) and healthy controls (HC). Methods: Searches were performed from inception through April 14, 2021. Meta-analyses with random-effects models were used to calculate the standardized mean difference ([SMD], 95%CI), and potential sources of heterogeneity were explored trough meta-regressions and subgroup analysis. Results: The meta-analysis included 23 studies on the following 14 cytokines: tumor necrosis factor (TNF)-a, IL-1, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, IL15, interferon (IFN)-g and sCD14. There were significantly higher concentrations of IL-6 (n=462 AUD and 408 HC; SMD = 0.523; 95%CI 0.136-0.909; p = 0.008) in AUD than HC. No significant differences were found in the other 13 cytokines. Conclusion: We found that IL-6 levels were significantly higher in individuals with AUD than HC and that other cytokines were not altered. This can be explained by the small number of studies, their methodological heterogeneity, and confounding factors (active use, abstinence, quantity, and physical or psychiatric illnesses, for example). Despite a great deal of evidence about alcohol and inflammatory diseases, studies assessing the role of neuroimmune signaling in the development and severity of AUD are still lacking.
publishDate 2022
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dc.date.accessioned.fl_str_mv 2023-08-01T03:32:58Z
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dc.relation.ispartof.pt_BR.fl_str_mv Revista brasileira de psiquiatria (1999). São Paulo. Vol. 44, no. 5 (2022), p. 548-556.
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