Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/254795 |
Resumo: | This report describes 2 events of degenerative myelopathy in 4- to 27-day-old piglets, with mortality rates reaching 40%. Sows were fed rations containing low levels of pantothenic acid. Piglets presented with severe depression, weakness, ataxia, and paresis, which were more pronounced in the pelvic limbs. No significant gross lesions were observed. Histologically, there were degeneration and necrosis of neurons in the spinal cord, primarily in the thoracic nucleus in the thoracic and lumbar segments, and motor neurons in nucleus IX of the ventral horn in the cervical and lumbar intumescence. Minimal-to-moderate axonal and myelin degeneration was observed in the dorsal funiculus of the spinal cord and in the dorsal and ventral nerve roots. Immunohistochemistry demonstrated depletion of acetylcholine neurotransmitters in motor neurons and accumulation of neurofilaments in the perikaryon of neurons in the thoracic nucleus and motor neurons. Ultrastructurally, the thoracic nucleus neurons and motor neurons showed dissolution of Nissl granulation. The topographical distribution of the lesions indicates damage to the second-order neurons of the spinocerebellar tract, first-order axon cuneocerebellar tract, and dorsal columnmedial lemniscus pathway as the cause of the conscious and unconscious proprioceptive deficit, and damage to the alpha motor neuron as the cause of the motor deficit. Clinical signs reversed and no new cases occurred after pantothenic acid levels were corrected in the ration, and piglets received parenteral administration of pantothenic acid. This study highlights the important and practical use of detailed neuropathological analysis to refine differential diagnosis. |
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Lorenzett, Marina PaulaArmien Medianero, Anibal GuillermoHenker, Luan CleberSchwertz, Claiton IsmaelCruz, Raquel Aparecida Sales daPanziera, WeldenBarros, Cláudio Severo LombardoDriemeier, DavidPavarini, Saulo Petinatti2023-02-14T03:22:11Z20230300-9858http://hdl.handle.net/10183/254795001161781This report describes 2 events of degenerative myelopathy in 4- to 27-day-old piglets, with mortality rates reaching 40%. Sows were fed rations containing low levels of pantothenic acid. Piglets presented with severe depression, weakness, ataxia, and paresis, which were more pronounced in the pelvic limbs. No significant gross lesions were observed. Histologically, there were degeneration and necrosis of neurons in the spinal cord, primarily in the thoracic nucleus in the thoracic and lumbar segments, and motor neurons in nucleus IX of the ventral horn in the cervical and lumbar intumescence. Minimal-to-moderate axonal and myelin degeneration was observed in the dorsal funiculus of the spinal cord and in the dorsal and ventral nerve roots. Immunohistochemistry demonstrated depletion of acetylcholine neurotransmitters in motor neurons and accumulation of neurofilaments in the perikaryon of neurons in the thoracic nucleus and motor neurons. Ultrastructurally, the thoracic nucleus neurons and motor neurons showed dissolution of Nissl granulation. The topographical distribution of the lesions indicates damage to the second-order neurons of the spinocerebellar tract, first-order axon cuneocerebellar tract, and dorsal columnmedial lemniscus pathway as the cause of the conscious and unconscious proprioceptive deficit, and damage to the alpha motor neuron as the cause of the motor deficit. Clinical signs reversed and no new cases occurred after pantothenic acid levels were corrected in the ration, and piglets received parenteral administration of pantothenic acid. This study highlights the important and practical use of detailed neuropathological analysis to refine differential diagnosis.application/pdfengVeterinary pathology. Thousand Oaks. Vol. 60, no. 1 (Jan. 2023), p. 101-114Doenças neurodegenerativasMielopatiaDeficiência de vitaminasÁcido pantotênicoSuínosAtaxiaChromatolysisConscious proprioceptionCuneocerebellar tractDorsal column-medial lemniscus pathwayMotor neuronsPantothenic acidParesisSpinocerebellar tractSwineThoracic nucleusUnconscious proprioceptionVitamin B5Wallerian degenerationMotor and somatosensory degenerative myelopathy responsive to pantothenic acid in pigletsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161781.pdf.txt001161781.pdf.txtExtracted Texttext/plain66188http://www.lume.ufrgs.br/bitstream/10183/254795/2/001161781.pdf.txt34c20a08b7bd784bcffa696f011bdb8fMD52ORIGINAL001161781.pdfTexto completo (inglês)application/pdf6918949http://www.lume.ufrgs.br/bitstream/10183/254795/1/001161781.pdf1bedba5649cb28e384b45f2fcb0e00c0MD5110183/2547952023-02-15 04:24:26.505818oai:www.lume.ufrgs.br:10183/254795Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-02-15T06:24:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
title |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
spellingShingle |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets Lorenzett, Marina Paula Doenças neurodegenerativas Mielopatia Deficiência de vitaminas Ácido pantotênico Suínos Ataxia Chromatolysis Conscious proprioception Cuneocerebellar tract Dorsal column-medial lemniscus pathway Motor neurons Pantothenic acid Paresis Spinocerebellar tract Swine Thoracic nucleus Unconscious proprioception Vitamin B5 Wallerian degeneration |
title_short |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
title_full |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
title_fullStr |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
title_full_unstemmed |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
title_sort |
Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets |
author |
Lorenzett, Marina Paula |
author_facet |
Lorenzett, Marina Paula Armien Medianero, Anibal Guillermo Henker, Luan Cleber Schwertz, Claiton Ismael Cruz, Raquel Aparecida Sales da Panziera, Welden Barros, Cláudio Severo Lombardo Driemeier, David Pavarini, Saulo Petinatti |
author_role |
author |
author2 |
Armien Medianero, Anibal Guillermo Henker, Luan Cleber Schwertz, Claiton Ismael Cruz, Raquel Aparecida Sales da Panziera, Welden Barros, Cláudio Severo Lombardo Driemeier, David Pavarini, Saulo Petinatti |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lorenzett, Marina Paula Armien Medianero, Anibal Guillermo Henker, Luan Cleber Schwertz, Claiton Ismael Cruz, Raquel Aparecida Sales da Panziera, Welden Barros, Cláudio Severo Lombardo Driemeier, David Pavarini, Saulo Petinatti |
dc.subject.por.fl_str_mv |
Doenças neurodegenerativas Mielopatia Deficiência de vitaminas Ácido pantotênico Suínos |
topic |
Doenças neurodegenerativas Mielopatia Deficiência de vitaminas Ácido pantotênico Suínos Ataxia Chromatolysis Conscious proprioception Cuneocerebellar tract Dorsal column-medial lemniscus pathway Motor neurons Pantothenic acid Paresis Spinocerebellar tract Swine Thoracic nucleus Unconscious proprioception Vitamin B5 Wallerian degeneration |
dc.subject.eng.fl_str_mv |
Ataxia Chromatolysis Conscious proprioception Cuneocerebellar tract Dorsal column-medial lemniscus pathway Motor neurons Pantothenic acid Paresis Spinocerebellar tract Swine Thoracic nucleus Unconscious proprioception Vitamin B5 Wallerian degeneration |
description |
This report describes 2 events of degenerative myelopathy in 4- to 27-day-old piglets, with mortality rates reaching 40%. Sows were fed rations containing low levels of pantothenic acid. Piglets presented with severe depression, weakness, ataxia, and paresis, which were more pronounced in the pelvic limbs. No significant gross lesions were observed. Histologically, there were degeneration and necrosis of neurons in the spinal cord, primarily in the thoracic nucleus in the thoracic and lumbar segments, and motor neurons in nucleus IX of the ventral horn in the cervical and lumbar intumescence. Minimal-to-moderate axonal and myelin degeneration was observed in the dorsal funiculus of the spinal cord and in the dorsal and ventral nerve roots. Immunohistochemistry demonstrated depletion of acetylcholine neurotransmitters in motor neurons and accumulation of neurofilaments in the perikaryon of neurons in the thoracic nucleus and motor neurons. Ultrastructurally, the thoracic nucleus neurons and motor neurons showed dissolution of Nissl granulation. The topographical distribution of the lesions indicates damage to the second-order neurons of the spinocerebellar tract, first-order axon cuneocerebellar tract, and dorsal columnmedial lemniscus pathway as the cause of the conscious and unconscious proprioceptive deficit, and damage to the alpha motor neuron as the cause of the motor deficit. Clinical signs reversed and no new cases occurred after pantothenic acid levels were corrected in the ration, and piglets received parenteral administration of pantothenic acid. This study highlights the important and practical use of detailed neuropathological analysis to refine differential diagnosis. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-02-14T03:22:11Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/254795 |
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0300-9858 |
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001161781 |
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http://hdl.handle.net/10183/254795 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Veterinary pathology. Thousand Oaks. Vol. 60, no. 1 (Jan. 2023), p. 101-114 |
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