Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/216835 |
Resumo: | Background Gestational diabetes mellitus (GDM) is a common condition, often associated with high maternal and fetal morbidity. The use of new tools for early GDM screening can contribute to metabolic control to reduce maternal and fetal risk. This study aimed to ascertain whether maternal visceral adipose tissue (VAT) measurement by ultrasound during the first half of pregnancy can predict the occurrence of GDM during the third trimester. Methods A prospective cohort study of 133 pregnant women with gestational age ≤20 weeks in an outpatient setting. VAT depth was measured by ultrasound at the maternal periumbilical region. GDM status was obtained through hospital charts during hospitalization to delivery. A Receiver Operator Characteristic (ROC) curve was used to determine the optimum threshold to predict GDM. Results According to the ROC curve, a 45mm threshold was identified as the best cut-off value, with 66% of accuracy to predict GDM. Crude and adjusted odds ratios (OR) for GDM were 13.4 (95%CI 2.9–61.1) and 8.9 (95%CI 1.9–42.2), respectively. A similar result was obtained among pre-gravid non-obese women, with crude and adjusted OR of 16.6 (95%CI 1.9–142.6) and 14.4 (95%CI 1.7–125.7), respectively. Among pre-gravid obese patients, a 45mm threshold did not reach statistical significance to predict GDM. Conclusion The high and significant OR found before and after adjustments provides additional evidence of a strong association between VAT and GDM. It appears that VAT measurement during the first half of pregnancy has great potential in identifying non-obese women at high risk for GDM. This evidence can assist obstetricians in correctly allocating resources among populations of pregnant women at risk, determined not only by pre-gravid body mass index (BMI). |
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Rocha, Alexandre da SilvaBernardi, Juliana RombaldiMatos, Salete deKretzer, Daniela CortésSchöffel, Alice CarvalhalGoldani, Marcelo ZubaranMagalhães, Jose Antonio de Azevedo2020-12-24T04:20:28Z20201932-6203http://hdl.handle.net/10183/216835001120026Background Gestational diabetes mellitus (GDM) is a common condition, often associated with high maternal and fetal morbidity. The use of new tools for early GDM screening can contribute to metabolic control to reduce maternal and fetal risk. This study aimed to ascertain whether maternal visceral adipose tissue (VAT) measurement by ultrasound during the first half of pregnancy can predict the occurrence of GDM during the third trimester. Methods A prospective cohort study of 133 pregnant women with gestational age ≤20 weeks in an outpatient setting. VAT depth was measured by ultrasound at the maternal periumbilical region. GDM status was obtained through hospital charts during hospitalization to delivery. A Receiver Operator Characteristic (ROC) curve was used to determine the optimum threshold to predict GDM. Results According to the ROC curve, a 45mm threshold was identified as the best cut-off value, with 66% of accuracy to predict GDM. Crude and adjusted odds ratios (OR) for GDM were 13.4 (95%CI 2.9–61.1) and 8.9 (95%CI 1.9–42.2), respectively. A similar result was obtained among pre-gravid non-obese women, with crude and adjusted OR of 16.6 (95%CI 1.9–142.6) and 14.4 (95%CI 1.7–125.7), respectively. Among pre-gravid obese patients, a 45mm threshold did not reach statistical significance to predict GDM. Conclusion The high and significant OR found before and after adjustments provides additional evidence of a strong association between VAT and GDM. It appears that VAT measurement during the first half of pregnancy has great potential in identifying non-obese women at high risk for GDM. This evidence can assist obstetricians in correctly allocating resources among populations of pregnant women at risk, determined not only by pre-gravid body mass index (BMI).application/pdfengPloS one. San Francisco. Vol. 15, no. 4 (Apr. 2020), e0232155, 9 p.Diabetes gestacionalGravidezGordura intra-abdominalMaternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001120026.pdf.txt001120026.pdf.txtExtracted Texttext/plain32842http://www.lume.ufrgs.br/bitstream/10183/216835/2/001120026.pdf.txt4e129e80ca01076afa9d006b8a037459MD52ORIGINAL001120026.pdfTexto completo (inglês)application/pdf541573http://www.lume.ufrgs.br/bitstream/10183/216835/1/001120026.pdfe617f35647d8b011ea51680f2388fe4dMD5110183/2168352023-09-24 03:37:15.702967oai:www.lume.ufrgs.br:10183/216835Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:37:15Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
title |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
spellingShingle |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study Rocha, Alexandre da Silva Diabetes gestacional Gravidez Gordura intra-abdominal |
title_short |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
title_full |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
title_fullStr |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
title_full_unstemmed |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
title_sort |
Maternal visceral adipose tissue during the first half of pregnancy predicts gestational diabetes at the time of delivery : a cohort study |
author |
Rocha, Alexandre da Silva |
author_facet |
Rocha, Alexandre da Silva Bernardi, Juliana Rombaldi Matos, Salete de Kretzer, Daniela Cortés Schöffel, Alice Carvalhal Goldani, Marcelo Zubaran Magalhães, Jose Antonio de Azevedo |
author_role |
author |
author2 |
Bernardi, Juliana Rombaldi Matos, Salete de Kretzer, Daniela Cortés Schöffel, Alice Carvalhal Goldani, Marcelo Zubaran Magalhães, Jose Antonio de Azevedo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha, Alexandre da Silva Bernardi, Juliana Rombaldi Matos, Salete de Kretzer, Daniela Cortés Schöffel, Alice Carvalhal Goldani, Marcelo Zubaran Magalhães, Jose Antonio de Azevedo |
dc.subject.por.fl_str_mv |
Diabetes gestacional Gravidez Gordura intra-abdominal |
topic |
Diabetes gestacional Gravidez Gordura intra-abdominal |
description |
Background Gestational diabetes mellitus (GDM) is a common condition, often associated with high maternal and fetal morbidity. The use of new tools for early GDM screening can contribute to metabolic control to reduce maternal and fetal risk. This study aimed to ascertain whether maternal visceral adipose tissue (VAT) measurement by ultrasound during the first half of pregnancy can predict the occurrence of GDM during the third trimester. Methods A prospective cohort study of 133 pregnant women with gestational age ≤20 weeks in an outpatient setting. VAT depth was measured by ultrasound at the maternal periumbilical region. GDM status was obtained through hospital charts during hospitalization to delivery. A Receiver Operator Characteristic (ROC) curve was used to determine the optimum threshold to predict GDM. Results According to the ROC curve, a 45mm threshold was identified as the best cut-off value, with 66% of accuracy to predict GDM. Crude and adjusted odds ratios (OR) for GDM were 13.4 (95%CI 2.9–61.1) and 8.9 (95%CI 1.9–42.2), respectively. A similar result was obtained among pre-gravid non-obese women, with crude and adjusted OR of 16.6 (95%CI 1.9–142.6) and 14.4 (95%CI 1.7–125.7), respectively. Among pre-gravid obese patients, a 45mm threshold did not reach statistical significance to predict GDM. Conclusion The high and significant OR found before and after adjustments provides additional evidence of a strong association between VAT and GDM. It appears that VAT measurement during the first half of pregnancy has great potential in identifying non-obese women at high risk for GDM. This evidence can assist obstetricians in correctly allocating resources among populations of pregnant women at risk, determined not only by pre-gravid body mass index (BMI). |
publishDate |
2020 |
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2020 |
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001120026 |
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PloS one. San Francisco. Vol. 15, no. 4 (Apr. 2020), e0232155, 9 p. |
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