Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200233 |
Resumo: | Ethnopharmacological relevance: In recent years, several studies aim to validate the traditional medicinal use of a variety of plant species, through evaluation of extract activity and/or isolation of active constituents. We discuss herein the latest studies on the ethnopharmacology of species with active secondary metabolites from the triterpene class. Aim of the review: This review aimed to verify, through bibliographic research, the correlation between traditional medicinal use and biological activity of natural sources, with emphasis on the triterpene class of active secondary metabolites. Methods: Literature research was done in ScienceDirect® database, using the keywords ethnopharmacology and triterpenes, from the period of 2015 and 2016. From 182 studies evaluated, 32 studies were selected. The selected studies were the ones relating the activity of a triterpene, isolated from a natural source extract, to its traditional medicinal use, or the studies relating the traditional medicinal use of a natural source and the activity of its extract, which may be due to the presence of a triterpene. Results: Twenty studies on the in vitro / in vivo activity of isolated triterpenes are reported here, and 12 studies where the activity of the extract might be related to the presence of triterpenes. The most cited activities for the class include antitumoral, anti-mycobacterial, antiplasmodial, antibacterial and anti-inflammatory. The medicinal parts mostly used for extraction were the leaves. The most cited triterpene was betulinic acid, presenting anxiolytic activity in vivo and antimycobacterial, antitumoral, and antiplasmodial activities in vitro. Conclusion: The relationship between traditional medicinal use and biological activity was demonstrated for a wide variety of natural source extracts as well as isolated compounds. Nevertheless, future studies are necessary focusing on understanding the pharmacological basis of the traditional use of some natural sources, as well as on generating conclusive data on their efficacy and safety, in order to validate their use in traditional medicine. |
id |
UFRGS-2_c8e2b6dd7073ba685708091f6711c061 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/200233 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Staudt, Andressa FinklerGnoatto, Simone Cristina BaggioCargnin, Simone Tasca2019-10-09T03:47:10Z2016http://hdl.handle.net/10183/200233001020780Ethnopharmacological relevance: In recent years, several studies aim to validate the traditional medicinal use of a variety of plant species, through evaluation of extract activity and/or isolation of active constituents. We discuss herein the latest studies on the ethnopharmacology of species with active secondary metabolites from the triterpene class. Aim of the review: This review aimed to verify, through bibliographic research, the correlation between traditional medicinal use and biological activity of natural sources, with emphasis on the triterpene class of active secondary metabolites. Methods: Literature research was done in ScienceDirect® database, using the keywords ethnopharmacology and triterpenes, from the period of 2015 and 2016. From 182 studies evaluated, 32 studies were selected. The selected studies were the ones relating the activity of a triterpene, isolated from a natural source extract, to its traditional medicinal use, or the studies relating the traditional medicinal use of a natural source and the activity of its extract, which may be due to the presence of a triterpene. Results: Twenty studies on the in vitro / in vivo activity of isolated triterpenes are reported here, and 12 studies where the activity of the extract might be related to the presence of triterpenes. The most cited activities for the class include antitumoral, anti-mycobacterial, antiplasmodial, antibacterial and anti-inflammatory. The medicinal parts mostly used for extraction were the leaves. The most cited triterpene was betulinic acid, presenting anxiolytic activity in vivo and antimycobacterial, antitumoral, and antiplasmodial activities in vitro. Conclusion: The relationship between traditional medicinal use and biological activity was demonstrated for a wide variety of natural source extracts as well as isolated compounds. Nevertheless, future studies are necessary focusing on understanding the pharmacological basis of the traditional use of some natural sources, as well as on generating conclusive data on their efficacy and safety, in order to validate their use in traditional medicine.application/pdfengFarmáciaBioactivityMedicinal useTraditional medicineNatural productsTriterpenoidsEthnopharmacology versus biological activity : a review with emphasis on the triterpene classinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal do Rio Grande do SulFaculdade de FarmáciaPorto Alegre, BR-RS2016Farmáciagraduaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001020780.pdf.txt001020780.pdf.txtExtracted Texttext/plain113902http://www.lume.ufrgs.br/bitstream/10183/200233/2/001020780.pdf.txt4967130bd3dbc22523e1da3c2576bb50MD52ORIGINAL001020780.pdfTexto completo (inglês)application/pdf695118http://www.lume.ufrgs.br/bitstream/10183/200233/1/001020780.pdfdde3164fad5743945b9ca38eeccf2d0aMD5110183/2002332019-10-10 03:48:58.260332oai:www.lume.ufrgs.br:10183/200233Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-10-10T06:48:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
title |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
spellingShingle |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class Staudt, Andressa Finkler Farmácia Bioactivity Medicinal use Traditional medicine Natural products Triterpenoids |
title_short |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
title_full |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
title_fullStr |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
title_full_unstemmed |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
title_sort |
Ethnopharmacology versus biological activity : a review with emphasis on the triterpene class |
author |
Staudt, Andressa Finkler |
author_facet |
Staudt, Andressa Finkler |
author_role |
author |
dc.contributor.author.fl_str_mv |
Staudt, Andressa Finkler |
dc.contributor.advisor1.fl_str_mv |
Gnoatto, Simone Cristina Baggio |
dc.contributor.advisor-co1.fl_str_mv |
Cargnin, Simone Tasca |
contributor_str_mv |
Gnoatto, Simone Cristina Baggio Cargnin, Simone Tasca |
dc.subject.por.fl_str_mv |
Farmácia |
topic |
Farmácia Bioactivity Medicinal use Traditional medicine Natural products Triterpenoids |
dc.subject.eng.fl_str_mv |
Bioactivity Medicinal use Traditional medicine Natural products Triterpenoids |
description |
Ethnopharmacological relevance: In recent years, several studies aim to validate the traditional medicinal use of a variety of plant species, through evaluation of extract activity and/or isolation of active constituents. We discuss herein the latest studies on the ethnopharmacology of species with active secondary metabolites from the triterpene class. Aim of the review: This review aimed to verify, through bibliographic research, the correlation between traditional medicinal use and biological activity of natural sources, with emphasis on the triterpene class of active secondary metabolites. Methods: Literature research was done in ScienceDirect® database, using the keywords ethnopharmacology and triterpenes, from the period of 2015 and 2016. From 182 studies evaluated, 32 studies were selected. The selected studies were the ones relating the activity of a triterpene, isolated from a natural source extract, to its traditional medicinal use, or the studies relating the traditional medicinal use of a natural source and the activity of its extract, which may be due to the presence of a triterpene. Results: Twenty studies on the in vitro / in vivo activity of isolated triterpenes are reported here, and 12 studies where the activity of the extract might be related to the presence of triterpenes. The most cited activities for the class include antitumoral, anti-mycobacterial, antiplasmodial, antibacterial and anti-inflammatory. The medicinal parts mostly used for extraction were the leaves. The most cited triterpene was betulinic acid, presenting anxiolytic activity in vivo and antimycobacterial, antitumoral, and antiplasmodial activities in vitro. Conclusion: The relationship between traditional medicinal use and biological activity was demonstrated for a wide variety of natural source extracts as well as isolated compounds. Nevertheless, future studies are necessary focusing on understanding the pharmacological basis of the traditional use of some natural sources, as well as on generating conclusive data on their efficacy and safety, in order to validate their use in traditional medicine. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2019-10-09T03:47:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/200233 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001020780 |
url |
http://hdl.handle.net/10183/200233 |
identifier_str_mv |
001020780 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/200233/2/001020780.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/200233/1/001020780.pdf |
bitstream.checksum.fl_str_mv |
4967130bd3dbc22523e1da3c2576bb50 dde3164fad5743945b9ca38eeccf2d0a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224584180006912 |