Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/220757 |
Resumo: | The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration. |
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Souza, Renato TeixeiraCosta, Maria LauraMayrink, JussaraFeitosa, Francisco Edson de LucenaRocha Filho, Edilberto Alves Pereira daLeite, Debora Farias BatistaVettorazzi, JaneteCalderon, Iracema de Mattos ParanhosSousa, Maria Helena dePassini Júnior, RenatoBaker, Philip NewtonKenny, Louise C.Cecatti, Jose Guilherme2021-05-13T04:24:57Z20202045-2322http://hdl.handle.net/10183/220757001123194The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration.application/pdfengScientific reports. London. Vol. 10 (2020), 855, 10 p.Fatores de riscoEpidemiologiaTrabalho de parto prematuroGravidezClinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous womenEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001123194.pdf.txt001123194.pdf.txtExtracted Texttext/plain42042http://www.lume.ufrgs.br/bitstream/10183/220757/2/001123194.pdf.txt2cab44b0edd53e4b930da91e6efe5a6eMD52ORIGINAL001123194.pdfTexto completo (inglês)application/pdf1143454http://www.lume.ufrgs.br/bitstream/10183/220757/1/001123194.pdf63ab289c7c88a908101df19b961faf51MD5110183/2207572021-05-26 04:29:10.890819oai:www.lume.ufrgs.br:10183/220757Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-05-26T07:29:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
title |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
spellingShingle |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women Souza, Renato Teixeira Fatores de risco Epidemiologia Trabalho de parto prematuro Gravidez |
title_short |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
title_full |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
title_fullStr |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
title_full_unstemmed |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
title_sort |
Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women |
author |
Souza, Renato Teixeira |
author_facet |
Souza, Renato Teixeira Costa, Maria Laura Mayrink, Jussara Feitosa, Francisco Edson de Lucena Rocha Filho, Edilberto Alves Pereira da Leite, Debora Farias Batista Vettorazzi, Janete Calderon, Iracema de Mattos Paranhos Sousa, Maria Helena de Passini Júnior, Renato Baker, Philip Newton Kenny, Louise C. Cecatti, Jose Guilherme |
author_role |
author |
author2 |
Costa, Maria Laura Mayrink, Jussara Feitosa, Francisco Edson de Lucena Rocha Filho, Edilberto Alves Pereira da Leite, Debora Farias Batista Vettorazzi, Janete Calderon, Iracema de Mattos Paranhos Sousa, Maria Helena de Passini Júnior, Renato Baker, Philip Newton Kenny, Louise C. Cecatti, Jose Guilherme |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Renato Teixeira Costa, Maria Laura Mayrink, Jussara Feitosa, Francisco Edson de Lucena Rocha Filho, Edilberto Alves Pereira da Leite, Debora Farias Batista Vettorazzi, Janete Calderon, Iracema de Mattos Paranhos Sousa, Maria Helena de Passini Júnior, Renato Baker, Philip Newton Kenny, Louise C. Cecatti, Jose Guilherme |
dc.subject.por.fl_str_mv |
Fatores de risco Epidemiologia Trabalho de parto prematuro Gravidez |
topic |
Fatores de risco Epidemiologia Trabalho de parto prematuro Gravidez |
description |
The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-05-13T04:24:57Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/220757 |
dc.identifier.issn.pt_BR.fl_str_mv |
2045-2322 |
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001123194 |
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2045-2322 001123194 |
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http://hdl.handle.net/10183/220757 |
dc.language.iso.fl_str_mv |
eng |
language |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 10 (2020), 855, 10 p. |
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openAccess |
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