Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women

Detalhes bibliográficos
Autor(a) principal: Souza, Renato Teixeira
Data de Publicação: 2020
Outros Autores: Costa, Maria Laura, Mayrink, Jussara, Feitosa, Francisco Edson de Lucena, Rocha Filho, Edilberto Alves Pereira da, Leite, Debora Farias Batista, Vettorazzi, Janete, Calderon, Iracema de Mattos Paranhos, Sousa, Maria Helena de, Passini Júnior, Renato, Baker, Philip Newton, Kenny, Louise C., Cecatti, Jose Guilherme
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/220757
Resumo: The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration.
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spelling Souza, Renato TeixeiraCosta, Maria LauraMayrink, JussaraFeitosa, Francisco Edson de LucenaRocha Filho, Edilberto Alves Pereira daLeite, Debora Farias BatistaVettorazzi, JaneteCalderon, Iracema de Mattos ParanhosSousa, Maria Helena dePassini Júnior, RenatoBaker, Philip NewtonKenny, Louise C.Cecatti, Jose Guilherme2021-05-13T04:24:57Z20202045-2322http://hdl.handle.net/10183/220757001123194The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration.application/pdfengScientific reports. London. Vol. 10 (2020), 855, 10 p.Fatores de riscoEpidemiologiaTrabalho de parto prematuroGravidezClinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous womenEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001123194.pdf.txt001123194.pdf.txtExtracted Texttext/plain42042http://www.lume.ufrgs.br/bitstream/10183/220757/2/001123194.pdf.txt2cab44b0edd53e4b930da91e6efe5a6eMD52ORIGINAL001123194.pdfTexto completo (inglês)application/pdf1143454http://www.lume.ufrgs.br/bitstream/10183/220757/1/001123194.pdf63ab289c7c88a908101df19b961faf51MD5110183/2207572021-05-26 04:29:10.890819oai:www.lume.ufrgs.br:10183/220757Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-05-26T07:29:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
title Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
spellingShingle Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
Souza, Renato Teixeira
Fatores de risco
Epidemiologia
Trabalho de parto prematuro
Gravidez
title_short Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
title_full Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
title_fullStr Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
title_full_unstemmed Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
title_sort Clinical and epidemiological factors associated with spontaneous preterm birth : a multicentre cohort of low risk nulliparous women
author Souza, Renato Teixeira
author_facet Souza, Renato Teixeira
Costa, Maria Laura
Mayrink, Jussara
Feitosa, Francisco Edson de Lucena
Rocha Filho, Edilberto Alves Pereira da
Leite, Debora Farias Batista
Vettorazzi, Janete
Calderon, Iracema de Mattos Paranhos
Sousa, Maria Helena de
Passini Júnior, Renato
Baker, Philip Newton
Kenny, Louise C.
Cecatti, Jose Guilherme
author_role author
author2 Costa, Maria Laura
Mayrink, Jussara
Feitosa, Francisco Edson de Lucena
Rocha Filho, Edilberto Alves Pereira da
Leite, Debora Farias Batista
Vettorazzi, Janete
Calderon, Iracema de Mattos Paranhos
Sousa, Maria Helena de
Passini Júnior, Renato
Baker, Philip Newton
Kenny, Louise C.
Cecatti, Jose Guilherme
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Renato Teixeira
Costa, Maria Laura
Mayrink, Jussara
Feitosa, Francisco Edson de Lucena
Rocha Filho, Edilberto Alves Pereira da
Leite, Debora Farias Batista
Vettorazzi, Janete
Calderon, Iracema de Mattos Paranhos
Sousa, Maria Helena de
Passini Júnior, Renato
Baker, Philip Newton
Kenny, Louise C.
Cecatti, Jose Guilherme
dc.subject.por.fl_str_mv Fatores de risco
Epidemiologia
Trabalho de parto prematuro
Gravidez
topic Fatores de risco
Epidemiologia
Trabalho de parto prematuro
Gravidez
description The objective of this study was to determine incidence and risk factors associated with spontaneous preterm birth (sPTB). It was a prospective multicentre cohort study performed in fve Brazilian referral maternity hospitals and enrolling nulliparous women at 19–21 weeks. Comprehensive maternal data collected during three study visits were addressed as potentially associated factors for sPTB. Bivariate and multivariate analysis estimated risk ratios. The main outcomes measures were birth before 37 weeks due to spontaneous preterm labour or premature rupture of membranes (sPTB). The comparison group was comprised of women with term births (≥37weeks). Outcome data was available for 1,165 women, 6.7% of whom had sPTB, 16% had consumed alcohol and 5% had used other illicit drugs during the frst half of pregnancy. Current drinking at 19–21 weeks (RR 3.96 95% CI [1.04–15.05]) and a short cervix from 18–24 weeks (RR 4.52 95% CI [1.08–19.01]) correlated with sPTB on bivariate analysis. Increased incidence of sPTB occurred in underweight women gaining weight below quartile 1 (14.8%), obese women gaining weight above quartile 3 (14.3%), women with a short cervix (<25mm) at 18–24 weeks (31.2%) and those with a short cervix and vaginal bleeding in the frst half of pregnancy (40%). Cervical length (RRadj 4.52 95% CI [1.08–19.01]) was independently associated with sPTB. In conclusion, the incidence of sPTB increased in some maternal phenotypes, representing potential groups of interest, the focus of preventive strategies. Similarly, nulliparous women with a short cervix in the second trimester require further exploration.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-05-13T04:24:57Z
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dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.nrb.pt_BR.fl_str_mv 001123194
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Scientific reports. London. Vol. 10 (2020), 855, 10 p.
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