CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/23392 |
Resumo: | Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro- Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this study were CYP1A1*2A (30%) and GSTP1*Val (42%) while the frequency of the GSTM1 null genotype was 34% and that of the GSTT1 null genotype was 28%. Significant differences in genotype distribution and allelic frequencies were detected between Brazilians of African and of European descent from Porto Alegre in terms of the polymorphisms CYP1A1*2A (p = 0.003), GSTP1-Ile105Val (p = 0.002) and theGSTM1 null genotype (p = 0.01) but there was no detectable significant difference in respect to GSTT1 null genotype frequencies |
id |
UFRGS-2_cbb3a37a1b1d89df6706b0d675122a67 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/23392 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Kvitko, KatiaGaspar, Pedro de AbreuTorres, Martiela RibeiroHutz, Mara Helena2010-06-05T04:17:25Z20061415-4757http://hdl.handle.net/10183/23392000566824Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro- Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this study were CYP1A1*2A (30%) and GSTP1*Val (42%) while the frequency of the GSTM1 null genotype was 34% and that of the GSTT1 null genotype was 28%. Significant differences in genotype distribution and allelic frequencies were detected between Brazilians of African and of European descent from Porto Alegre in terms of the polymorphisms CYP1A1*2A (p = 0.003), GSTP1-Ile105Val (p = 0.002) and theGSTM1 null genotype (p = 0.01) but there was no detectable significant difference in respect to GSTT1 null genotype frequenciesapplication/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 29, no. 4 (Dec. 2006), p. 613-616GenéticaPolimorfismoAfricanBrazilianCYP1A1EuropeanGSTsPorto AlegreCYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian groupinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000566824.pdf000566824.pdfTexto completo (inglês)application/pdf63908http://www.lume.ufrgs.br/bitstream/10183/23392/1/000566824.pdf2bf5c742a3d4432ede8cb97f90aced10MD51TEXT000566824.pdf.txt000566824.pdf.txtExtracted Texttext/plain18713http://www.lume.ufrgs.br/bitstream/10183/23392/2/000566824.pdf.txt562fe1337b93e47d25c260aef8b6d19aMD52THUMBNAIL000566824.pdf.jpg000566824.pdf.jpgGenerated Thumbnailimage/jpeg1789http://www.lume.ufrgs.br/bitstream/10183/23392/3/000566824.pdf.jpg8cdbf5e028e445e838aa5ef8b5fa0c1fMD5310183/233922018-10-09 07:59:19.693oai:www.lume.ufrgs.br:10183/23392Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-09T10:59:19Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
title |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
spellingShingle |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group Kvitko, Katia Genética Polimorfismo African Brazilian CYP1A1 European GSTs Porto Alegre |
title_short |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
title_full |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
title_fullStr |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
title_full_unstemmed |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
title_sort |
CYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian group |
author |
Kvitko, Katia |
author_facet |
Kvitko, Katia Gaspar, Pedro de Abreu Torres, Martiela Ribeiro Hutz, Mara Helena |
author_role |
author |
author2 |
Gaspar, Pedro de Abreu Torres, Martiela Ribeiro Hutz, Mara Helena |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Kvitko, Katia Gaspar, Pedro de Abreu Torres, Martiela Ribeiro Hutz, Mara Helena |
dc.subject.por.fl_str_mv |
Genética Polimorfismo |
topic |
Genética Polimorfismo African Brazilian CYP1A1 European GSTs Porto Alegre |
dc.subject.eng.fl_str_mv |
African Brazilian CYP1A1 European GSTs Porto Alegre |
description |
Gene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro- Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this study were CYP1A1*2A (30%) and GSTP1*Val (42%) while the frequency of the GSTM1 null genotype was 34% and that of the GSTT1 null genotype was 28%. Significant differences in genotype distribution and allelic frequencies were detected between Brazilians of African and of European descent from Porto Alegre in terms of the polymorphisms CYP1A1*2A (p = 0.003), GSTP1-Ile105Val (p = 0.002) and theGSTM1 null genotype (p = 0.01) but there was no detectable significant difference in respect to GSTT1 null genotype frequencies |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2010-06-05T04:17:25Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/23392 |
dc.identifier.issn.pt_BR.fl_str_mv |
1415-4757 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000566824 |
identifier_str_mv |
1415-4757 000566824 |
url |
http://hdl.handle.net/10183/23392 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto. Vol. 29, no. 4 (Dec. 2006), p. 613-616 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/23392/1/000566824.pdf http://www.lume.ufrgs.br/bitstream/10183/23392/2/000566824.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/23392/3/000566824.pdf.jpg |
bitstream.checksum.fl_str_mv |
2bf5c742a3d4432ede8cb97f90aced10 562fe1337b93e47d25c260aef8b6d19a 8cdbf5e028e445e838aa5ef8b5fa0c1f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224718526709760 |