Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267834 |
Resumo: | Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we used the CMAP and LINCS databases. For molecular docking, we used the DockThor web server. Our results suggest that pirfenidone and colchicine are promising drugs to treat cardiovascular disease in MPS patients. We also provide a brief description of good practices for the repositioning analysis. Furthermore, the list of drugs and related MPS-enriched genes could be helpful to new treatments and considered for pathophysiological studies. |
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Silva, Gerda Cristal VillalbaKruger, Thiago SteindorffSchuh, Roselena SilvestriFlores, Natália CardosoMatte, Ursula da Silveira2023-11-30T03:23:54Z20222075-1729http://hdl.handle.net/10183/267834001177185Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we used the CMAP and LINCS databases. For molecular docking, we used the DockThor web server. Our results suggest that pirfenidone and colchicine are promising drugs to treat cardiovascular disease in MPS patients. We also provide a brief description of good practices for the repositioning analysis. Furthermore, the list of drugs and related MPS-enriched genes could be helpful to new treatments and considered for pathophysiological studies.application/pdfengLife. Basel. Vol. 12, no. 12 (Dec. 2022), e2085, 12 p.BioinformáticaDoenças cardiovascularesReposicionamento de medicamentosGene expression analysisLysosomal storage diseasesDrug repositioning applied to cardiovascular disease in MucopolysaccharidosisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001177185.pdf.txt001177185.pdf.txtExtracted Texttext/plain48376http://www.lume.ufrgs.br/bitstream/10183/267834/2/001177185.pdf.txta59a4d39d5a1249005d80524aee8bf1eMD52ORIGINAL001177185.pdfTexto completo (inglês)application/pdf7714635http://www.lume.ufrgs.br/bitstream/10183/267834/1/001177185.pdfae6d3d29142fa2e19cdc25c1d5e5e626MD5110183/2678342023-12-01 04:25:51.824994oai:www.lume.ufrgs.br:10183/267834Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-12-01T06:25:51Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
title |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
spellingShingle |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis Silva, Gerda Cristal Villalba Bioinformática Doenças cardiovasculares Reposicionamento de medicamentos Gene expression analysis Lysosomal storage diseases |
title_short |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
title_full |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
title_fullStr |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
title_full_unstemmed |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
title_sort |
Drug repositioning applied to cardiovascular disease in Mucopolysaccharidosis |
author |
Silva, Gerda Cristal Villalba |
author_facet |
Silva, Gerda Cristal Villalba Kruger, Thiago Steindorff Schuh, Roselena Silvestri Flores, Natália Cardoso Matte, Ursula da Silveira |
author_role |
author |
author2 |
Kruger, Thiago Steindorff Schuh, Roselena Silvestri Flores, Natália Cardoso Matte, Ursula da Silveira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Gerda Cristal Villalba Kruger, Thiago Steindorff Schuh, Roselena Silvestri Flores, Natália Cardoso Matte, Ursula da Silveira |
dc.subject.por.fl_str_mv |
Bioinformática Doenças cardiovasculares Reposicionamento de medicamentos |
topic |
Bioinformática Doenças cardiovasculares Reposicionamento de medicamentos Gene expression analysis Lysosomal storage diseases |
dc.subject.eng.fl_str_mv |
Gene expression analysis Lysosomal storage diseases |
description |
Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we used the CMAP and LINCS databases. For molecular docking, we used the DockThor web server. Our results suggest that pirfenidone and colchicine are promising drugs to treat cardiovascular disease in MPS patients. We also provide a brief description of good practices for the repositioning analysis. Furthermore, the list of drugs and related MPS-enriched genes could be helpful to new treatments and considered for pathophysiological studies. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-11-30T03:23:54Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267834 |
dc.identifier.issn.pt_BR.fl_str_mv |
2075-1729 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001177185 |
identifier_str_mv |
2075-1729 001177185 |
url |
http://hdl.handle.net/10183/267834 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Life. Basel. Vol. 12, no. 12 (Dec. 2022), e2085, 12 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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