Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions

Detalhes bibliográficos
Autor(a) principal: Friedrich, Rossana Barcellos
Data de Publicação: 2008
Outros Autores: Fontana, Márcia Camponogara, Beck, Ruy Carlos Ruver, Pohlmann, Adriana Raffin, Guterres, Silvia Stanisçuaski
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72864
Resumo: The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189–253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.
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spelling Friedrich, Rossana BarcellosFontana, Márcia CamponogaraBeck, Ruy Carlos RuverPohlmann, Adriana RaffinGuterres, Silvia Stanisçuaski2013-07-02T01:43:14Z20080100-4042http://hdl.handle.net/10183/72864000663737The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189–253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.application/pdfengQuímica nova. São Paulo. Vol. 31, n. 5 (ago. 2008), p. 1131-1136Nanocápsulas : Características físico-químicasNanopartículasDexamethasoneNanocapsulesNanoparticlesDevelopment and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensionsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000663737.pdf000663737.pdfTexto completo (inglês)application/pdf71472http://www.lume.ufrgs.br/bitstream/10183/72864/1/000663737.pdf6e2806ca04e8dd31c65c7dc7761c7a08MD51TEXT000663737.pdf.txt000663737.pdf.txtExtracted Texttext/plain38089http://www.lume.ufrgs.br/bitstream/10183/72864/2/000663737.pdf.txt9a2be20abad6c2b293708cae565aa872MD52THUMBNAIL000663737.pdf.jpg000663737.pdf.jpgGenerated Thumbnailimage/jpeg1960http://www.lume.ufrgs.br/bitstream/10183/72864/3/000663737.pdf.jpg6687d475d846a1dd37b4949e584068fcMD5310183/728642019-12-28 05:02:25.133922oai:www.lume.ufrgs.br:10183/72864Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-12-28T07:02:25Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
spellingShingle Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
Friedrich, Rossana Barcellos
Nanocápsulas : Características físico-químicas
Nanopartículas
Dexamethasone
Nanocapsules
Nanoparticles
title_short Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_full Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_fullStr Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_full_unstemmed Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
title_sort Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions
author Friedrich, Rossana Barcellos
author_facet Friedrich, Rossana Barcellos
Fontana, Márcia Camponogara
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Guterres, Silvia Stanisçuaski
author_role author
author2 Fontana, Márcia Camponogara
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Guterres, Silvia Stanisçuaski
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Friedrich, Rossana Barcellos
Fontana, Márcia Camponogara
Beck, Ruy Carlos Ruver
Pohlmann, Adriana Raffin
Guterres, Silvia Stanisçuaski
dc.subject.por.fl_str_mv Nanocápsulas : Características físico-químicas
Nanopartículas
topic Nanocápsulas : Características físico-químicas
Nanopartículas
Dexamethasone
Nanocapsules
Nanoparticles
dc.subject.eng.fl_str_mv Dexamethasone
Nanocapsules
Nanoparticles
description The influence of drug concentration, oil phase, and surfactants on the characteristics of dexamethasone-loaded nanocapsules was investigated. The best formulations were obtained at dexamethasone concentrations of 0.25 and 0.50 mg.mL-1 (encapsulation efficiency: 80-90%; mean size: 189–253 nm). The type of oil phase influenced only the stability of dexamethasone-loaded nanocapsules. The association of polysorbate 80 and sorbitan monooleate provided a more stable formulation. Sunflower oil and sorbitan sesquioleate used for the first time as oil phase and surfactant for nanocapsules, respectively, have allowed obtaining suspensions with low mean size and narrow size distribution.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:14Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72864
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000663737
identifier_str_mv 0100-4042
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 31, n. 5 (ago. 2008), p. 1131-1136
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