Cell sorting based on motility differences

Detalhes bibliográficos
Autor(a) principal: Beatrici, Carine Priscila
Data de Publicação: 2011
Outros Autores: Brunnet, Leonardo Gregory
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/101826
Resumo: Self-propelled particles are used to simulate cell aggregates in a model considering homogeneous adhesion forces between cells and using only motility differences as segregation drivers. The tendency of cells to follow their neighbors is also included in the formulation. Three model variants are explored, and the conditions on which motility differences may produce segregation are mapped in parameter diagrams. The evolution of the order parameter measuring cell segregation is similar to those found by models based on differential adhesion. It is also found that, considering only velocity differences, the faster cells envelope the slower ones, which is opposite to the ordering observed in early experiments by Jones and co-workers [Jones, Evans, and Lee, Exp. Cell. Res. 180, 287 (1989)].
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spelling Beatrici, Carine PriscilaBrunnet, Leonardo Gregory2014-08-26T09:26:15Z20111539-3755http://hdl.handle.net/10183/101826000794877Self-propelled particles are used to simulate cell aggregates in a model considering homogeneous adhesion forces between cells and using only motility differences as segregation drivers. The tendency of cells to follow their neighbors is also included in the formulation. Three model variants are explored, and the conditions on which motility differences may produce segregation are mapped in parameter diagrams. The evolution of the order parameter measuring cell segregation is similar to those found by models based on differential adhesion. It is also found that, considering only velocity differences, the faster cells envelope the slower ones, which is opposite to the ordering observed in early experiments by Jones and co-workers [Jones, Evans, and Lee, Exp. Cell. Res. 180, 287 (1989)].application/pdfengPhysical review. E, Statistical, nonlinear, and soft matter physics. Vol. 84, no. 3 (Sep. 2011), 031927, 5 p.BiofísicaBiomecânicaTransporte celularAdesãoAgregacaoCell sorting based on motility differencesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000794877.pdf000794877.pdfTexto completo (inglês)application/pdf764221http://www.lume.ufrgs.br/bitstream/10183/101826/1/000794877.pdf20891f99075b4430da45486c80ef43e0MD51TEXT000794877.pdf.txt000794877.pdf.txtExtracted Texttext/plain22017http://www.lume.ufrgs.br/bitstream/10183/101826/2/000794877.pdf.txtf78ae459740c79af75ba519f906a1214MD52THUMBNAIL000794877.pdf.jpg000794877.pdf.jpgGenerated Thumbnailimage/jpeg2116http://www.lume.ufrgs.br/bitstream/10183/101826/3/000794877.pdf.jpg0a11a95a27f44ab9c1729e01348f1fc5MD5310183/1018262024-05-18 06:24:16.235451oai:www.lume.ufrgs.br:10183/101826Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-05-18T09:24:16Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Cell sorting based on motility differences
title Cell sorting based on motility differences
spellingShingle Cell sorting based on motility differences
Beatrici, Carine Priscila
Biofísica
Biomecânica
Transporte celular
Adesão
Agregacao
title_short Cell sorting based on motility differences
title_full Cell sorting based on motility differences
title_fullStr Cell sorting based on motility differences
title_full_unstemmed Cell sorting based on motility differences
title_sort Cell sorting based on motility differences
author Beatrici, Carine Priscila
author_facet Beatrici, Carine Priscila
Brunnet, Leonardo Gregory
author_role author
author2 Brunnet, Leonardo Gregory
author2_role author
dc.contributor.author.fl_str_mv Beatrici, Carine Priscila
Brunnet, Leonardo Gregory
dc.subject.por.fl_str_mv Biofísica
Biomecânica
Transporte celular
Adesão
Agregacao
topic Biofísica
Biomecânica
Transporte celular
Adesão
Agregacao
description Self-propelled particles are used to simulate cell aggregates in a model considering homogeneous adhesion forces between cells and using only motility differences as segregation drivers. The tendency of cells to follow their neighbors is also included in the formulation. Three model variants are explored, and the conditions on which motility differences may produce segregation are mapped in parameter diagrams. The evolution of the order parameter measuring cell segregation is similar to those found by models based on differential adhesion. It is also found that, considering only velocity differences, the faster cells envelope the slower ones, which is opposite to the ordering observed in early experiments by Jones and co-workers [Jones, Evans, and Lee, Exp. Cell. Res. 180, 287 (1989)].
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dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-08-26T09:26:15Z
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dc.identifier.issn.pt_BR.fl_str_mv 1539-3755
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Physical review. E, Statistical, nonlinear, and soft matter physics. Vol. 84, no. 3 (Sep. 2011), 031927, 5 p.
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