Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration

Detalhes bibliográficos
Autor(a) principal: Vieira, Silvia Regina Rios
Data de Publicação: 2003
Outros Autores: Goldstein, Ivan, Lenaour, Gilles, Marquette, Charles-Hugo, Rouby, Jean-Jacques, Experimental ICU Study Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/19704
Resumo: Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration.
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spelling Vieira, Silvia Regina RiosGoldstein, IvanLenaour, GillesMarquette, Charles-HugoRouby, Jean-JacquesExperimental ICU Study Group2010-04-16T09:11:17Z20031413-8670http://hdl.handle.net/10183/19704000387893Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration.application/pdfengThe Brazilian journal of infectious diseases. Vol. 7, n. 3 (jun. 2003), 216-223Ventiladores mecânicosPneumonia associada à ventilação mecânicaVentilator associated pneumoniaExperimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aerationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000387893.pdf000387893.pdfTexto completo (inglês)application/pdf52238http://www.lume.ufrgs.br/bitstream/10183/19704/1/000387893.pdf2ff4aedf9de4f3e7e659f2ddcb00a4beMD51TEXT000387893.pdf.txt000387893.pdf.txtExtracted Texttext/plain29370http://www.lume.ufrgs.br/bitstream/10183/19704/2/000387893.pdf.txt1432eb2a6d7c78ba2e68fe940a0d13a2MD52THUMBNAIL000387893.pdf.jpg000387893.pdf.jpgGenerated Thumbnailimage/jpeg2023http://www.lume.ufrgs.br/bitstream/10183/19704/3/000387893.pdf.jpg0145235e50f8ef653f38732170914806MD5310183/197042023-08-10 03:31:10.292753oai:www.lume.ufrgs.br:10183/19704Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-10T06:31:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
title Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
spellingShingle Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
Vieira, Silvia Regina Rios
Ventiladores mecânicos
Pneumonia associada à ventilação mecânica
Ventilator associated pneumonia
title_short Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
title_full Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
title_fullStr Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
title_full_unstemmed Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
title_sort Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
author Vieira, Silvia Regina Rios
author_facet Vieira, Silvia Regina Rios
Goldstein, Ivan
Lenaour, Gilles
Marquette, Charles-Hugo
Rouby, Jean-Jacques
Experimental ICU Study Group
author_role author
author2 Goldstein, Ivan
Lenaour, Gilles
Marquette, Charles-Hugo
Rouby, Jean-Jacques
Experimental ICU Study Group
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Silvia Regina Rios
Goldstein, Ivan
Lenaour, Gilles
Marquette, Charles-Hugo
Rouby, Jean-Jacques
Experimental ICU Study Group
dc.subject.por.fl_str_mv Ventiladores mecânicos
Pneumonia associada à ventilação mecânica
topic Ventiladores mecânicos
Pneumonia associada à ventilação mecânica
Ventilator associated pneumonia
dc.subject.eng.fl_str_mv Ventilator associated pneumonia
description Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration.
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dc.relation.ispartof.pt_BR.fl_str_mv The Brazilian journal of infectious diseases. Vol. 7, n. 3 (jun. 2003), 216-223
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