Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/19704 |
Resumo: | Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration. |
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Vieira, Silvia Regina RiosGoldstein, IvanLenaour, GillesMarquette, Charles-HugoRouby, Jean-JacquesExperimental ICU Study Group2010-04-16T09:11:17Z20031413-8670http://hdl.handle.net/10183/19704000387893Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration.application/pdfengThe Brazilian journal of infectious diseases. Vol. 7, n. 3 (jun. 2003), 216-223Ventiladores mecânicosPneumonia associada à ventilação mecânicaVentilator associated pneumoniaExperimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aerationEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000387893.pdf000387893.pdfTexto completo (inglês)application/pdf52238http://www.lume.ufrgs.br/bitstream/10183/19704/1/000387893.pdf2ff4aedf9de4f3e7e659f2ddcb00a4beMD51TEXT000387893.pdf.txt000387893.pdf.txtExtracted Texttext/plain29370http://www.lume.ufrgs.br/bitstream/10183/19704/2/000387893.pdf.txt1432eb2a6d7c78ba2e68fe940a0d13a2MD52THUMBNAIL000387893.pdf.jpg000387893.pdf.jpgGenerated Thumbnailimage/jpeg2023http://www.lume.ufrgs.br/bitstream/10183/19704/3/000387893.pdf.jpg0145235e50f8ef653f38732170914806MD5310183/197042023-08-10 03:31:10.292753oai:www.lume.ufrgs.br:10183/19704Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-10T06:31:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
title |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
spellingShingle |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration Vieira, Silvia Regina Rios Ventiladores mecânicos Pneumonia associada à ventilação mecânica Ventilator associated pneumonia |
title_short |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
title_full |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
title_fullStr |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
title_full_unstemmed |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
title_sort |
Experimental ventilator-associated pneumonia : distribution of lung infection and consequences for lung aeration |
author |
Vieira, Silvia Regina Rios |
author_facet |
Vieira, Silvia Regina Rios Goldstein, Ivan Lenaour, Gilles Marquette, Charles-Hugo Rouby, Jean-Jacques Experimental ICU Study Group |
author_role |
author |
author2 |
Goldstein, Ivan Lenaour, Gilles Marquette, Charles-Hugo Rouby, Jean-Jacques Experimental ICU Study Group |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Silvia Regina Rios Goldstein, Ivan Lenaour, Gilles Marquette, Charles-Hugo Rouby, Jean-Jacques Experimental ICU Study Group |
dc.subject.por.fl_str_mv |
Ventiladores mecânicos Pneumonia associada à ventilação mecânica |
topic |
Ventiladores mecânicos Pneumonia associada à ventilação mecânica Ventilator associated pneumonia |
dc.subject.eng.fl_str_mv |
Ventilator associated pneumonia |
description |
Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains unknown. We used an experimental model to evaluate the distribution of lung infection, considering its anteroposterior and cephalocaudal gradient, and its impact on lung aeration. Ten healthy domestic piglets were anesthetized, paralyzed and mechanically ventilated for 59 hours in the prone position. At the end of the experiment they were sacrificed and their lungs were fixed. Six segments were analyzed: a non-dependant (ND) and a dependant (D) segment of the upper (UL), middle (ML) and lower (LL) lobes. The presence of healthy lung or of histological infectious lesions was analyzed with a semiquantitative method. The regional distribution of lung infection was compared between upper, middle and lower lobes, as well as between dependant and non-dependant regions. The presence of infectious lesions was correlated with measurements of lung aeration. Nine of the ten piglets developed VAP. Infectious lesions were distributed along a sterno-vertebral and a cephalocaudal gradient; the lower and middle lobes were more frequently infected than the upper lobes. There was an inverse correlation (R= - 0.902) between the development of lung lesions and lung aeration. In conclusion, VAP was a frequent complication in healthy mechanically ventilated piglets, showing an anteroposterior as well as a cephalocaudal gradient. As expected, development of lung infection was accompanied by a corresponding loss of aeration. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2010-04-16T09:11:17Z |
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1413-8670 |
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000387893 |
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http://hdl.handle.net/10183/19704 |
dc.language.iso.fl_str_mv |
eng |
language |
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dc.relation.ispartof.pt_BR.fl_str_mv |
The Brazilian journal of infectious diseases. Vol. 7, n. 3 (jun. 2003), 216-223 |
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openAccess |
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