Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/49850 |
Resumo: | Objective: Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4). Materials and Methods: Forty-eight male Wistar rats aged 45-50 days, weighing 150-180 grams were used. Twenty-two rats underwent CCl4-induced cirrhosis with CCl4 0.25 mL/Kg weekly intragastrically once a week, during 10 weeks. Additionally, they had a 44% food restriction diet (Group 1). The control group was divided in two subgroups: 13 rats had a 44% food restriction diet and no CCl4 (Group 2) and 10 rats were not submitted to CCl4 or food restriction (Group 3). After 10 weeks, the rats were sacrificed and liver sections were collected for histological analysis. The testicular analysis was carried out to evaluate the frequency of tubules in stages VIII and XIV. Results: The mean rates of stage VIII in animals with food restriction plus CCl4-induced cirrhosis and food restriction without CCl4 were significantly different from animals without either food restriction or CCl4 (18.1 ± 5.5%, 20.5 ± 2.5% and 13.4 ± 3.5%, respectively, p = 0.002). The mean rate of stage VIII in rats with cirrhosis was not significantly different from rats without cirrhosis (18.1 ± 5.5% and 17.4 ± 4.6% respectively). The mean frequency of stage XIV in rats with cirrhosis was significantly greater than rats without cirrhosis (4.7 ± 2.3% and 6.8 ± 1.9% respectively, p = 0.027). Conclusion: Animals with CCl4-induced cirrhosis and food restriction have shown alterations in spermatogenic cycle that were not seen in rats without CCl4-induced cirrhosis and food restriction. |
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Mesquita, Marilise OliveiraRamos, Ana Regina LimaWinkelmann, Leonardo VoglinoMatte, Ursula da SilveiraGoldani, Helena Ayako SuenoSilveira, Themis Reverbel da2012-06-29T01:32:38Z20061677-5538http://hdl.handle.net/10183/49850000567014Objective: Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4). Materials and Methods: Forty-eight male Wistar rats aged 45-50 days, weighing 150-180 grams were used. Twenty-two rats underwent CCl4-induced cirrhosis with CCl4 0.25 mL/Kg weekly intragastrically once a week, during 10 weeks. Additionally, they had a 44% food restriction diet (Group 1). The control group was divided in two subgroups: 13 rats had a 44% food restriction diet and no CCl4 (Group 2) and 10 rats were not submitted to CCl4 or food restriction (Group 3). After 10 weeks, the rats were sacrificed and liver sections were collected for histological analysis. The testicular analysis was carried out to evaluate the frequency of tubules in stages VIII and XIV. Results: The mean rates of stage VIII in animals with food restriction plus CCl4-induced cirrhosis and food restriction without CCl4 were significantly different from animals without either food restriction or CCl4 (18.1 ± 5.5%, 20.5 ± 2.5% and 13.4 ± 3.5%, respectively, p = 0.002). The mean rate of stage VIII in rats with cirrhosis was not significantly different from rats without cirrhosis (18.1 ± 5.5% and 17.4 ± 4.6% respectively). The mean frequency of stage XIV in rats with cirrhosis was significantly greater than rats without cirrhosis (4.7 ± 2.3% and 6.8 ± 1.9% respectively, p = 0.027). Conclusion: Animals with CCl4-induced cirrhosis and food restriction have shown alterations in spermatogenic cycle that were not seen in rats without CCl4-induced cirrhosis and food restriction.application/pdfengInternational braz j urol. Vol. 32, n. 1 (jan./feb. 2006), p. 94-99RatosCirrose hepáticaTetracloreto de carbonoPrivação de alimentosEspermatogêneseRatsLiver cirrhosisExperimentalCarbon tetrachlorideFood deprivationSpermatogenesisSeminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000567014.pdf000567014.pdfTexto completo (inglês)application/pdf74643http://www.lume.ufrgs.br/bitstream/10183/49850/1/000567014.pdf6a9c660212d076fd8c7de031845eccf3MD51TEXT000567014.pdf.txt000567014.pdf.txtExtracted Texttext/plain21327http://www.lume.ufrgs.br/bitstream/10183/49850/2/000567014.pdf.txtf5ce6af1ef3c9a5379535a5e8546599cMD52THUMBNAIL000567014.pdf.jpg000567014.pdf.jpgGenerated Thumbnailimage/jpeg1707http://www.lume.ufrgs.br/bitstream/10183/49850/3/000567014.pdf.jpg7b6763d5c56c913b4767547aa13d031cMD5310183/498502023-06-02 03:29:06.647914oai:www.lume.ufrgs.br:10183/49850Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-02T06:29:06Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
title |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
spellingShingle |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis Mesquita, Marilise Oliveira Ratos Cirrose hepática Tetracloreto de carbono Privação de alimentos Espermatogênese Rats Liver cirrhosis Experimental Carbon tetrachloride Food deprivation Spermatogenesis |
title_short |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
title_full |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
title_fullStr |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
title_full_unstemmed |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
title_sort |
Seminiferous epithelium of rats with food restriction and carbon tetrachloride-induced cirrhosis |
author |
Mesquita, Marilise Oliveira |
author_facet |
Mesquita, Marilise Oliveira Ramos, Ana Regina Lima Winkelmann, Leonardo Voglino Matte, Ursula da Silveira Goldani, Helena Ayako Sueno Silveira, Themis Reverbel da |
author_role |
author |
author2 |
Ramos, Ana Regina Lima Winkelmann, Leonardo Voglino Matte, Ursula da Silveira Goldani, Helena Ayako Sueno Silveira, Themis Reverbel da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Mesquita, Marilise Oliveira Ramos, Ana Regina Lima Winkelmann, Leonardo Voglino Matte, Ursula da Silveira Goldani, Helena Ayako Sueno Silveira, Themis Reverbel da |
dc.subject.por.fl_str_mv |
Ratos Cirrose hepática Tetracloreto de carbono Privação de alimentos Espermatogênese |
topic |
Ratos Cirrose hepática Tetracloreto de carbono Privação de alimentos Espermatogênese Rats Liver cirrhosis Experimental Carbon tetrachloride Food deprivation Spermatogenesis |
dc.subject.eng.fl_str_mv |
Rats Liver cirrhosis Experimental Carbon tetrachloride Food deprivation Spermatogenesis |
description |
Objective: Analyze the changes in the seminiferous epithelium in rats with carbon tetrachloride-induced cirrhosis (CCl4). Materials and Methods: Forty-eight male Wistar rats aged 45-50 days, weighing 150-180 grams were used. Twenty-two rats underwent CCl4-induced cirrhosis with CCl4 0.25 mL/Kg weekly intragastrically once a week, during 10 weeks. Additionally, they had a 44% food restriction diet (Group 1). The control group was divided in two subgroups: 13 rats had a 44% food restriction diet and no CCl4 (Group 2) and 10 rats were not submitted to CCl4 or food restriction (Group 3). After 10 weeks, the rats were sacrificed and liver sections were collected for histological analysis. The testicular analysis was carried out to evaluate the frequency of tubules in stages VIII and XIV. Results: The mean rates of stage VIII in animals with food restriction plus CCl4-induced cirrhosis and food restriction without CCl4 were significantly different from animals without either food restriction or CCl4 (18.1 ± 5.5%, 20.5 ± 2.5% and 13.4 ± 3.5%, respectively, p = 0.002). The mean rate of stage VIII in rats with cirrhosis was not significantly different from rats without cirrhosis (18.1 ± 5.5% and 17.4 ± 4.6% respectively). The mean frequency of stage XIV in rats with cirrhosis was significantly greater than rats without cirrhosis (4.7 ± 2.3% and 6.8 ± 1.9% respectively, p = 0.027). Conclusion: Animals with CCl4-induced cirrhosis and food restriction have shown alterations in spermatogenic cycle that were not seen in rats without CCl4-induced cirrhosis and food restriction. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
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2012-06-29T01:32:38Z |
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http://hdl.handle.net/10183/49850 |
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1677-5538 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000567014 |
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http://hdl.handle.net/10183/49850 |
dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
International braz j urol. Vol. 32, n. 1 (jan./feb. 2006), p. 94-99 |
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