Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

• Autor(a) principal: Puricelli, Edela
• Data de Publicação: 2010
• Outros Autores: Corsetti, Adriana, Ponzoni, Deise, Martins, Gustavo Lisboa, Leite, Mauro Gomes Trein, Santos, Luis Alberto dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/30488
• topic: Materiais biocompatíveis; Regeneração óssea; Cimentos; Enxerto osseo

Background: In this study, the biocompatibility, stability and osteotransductivity of a new cement based on alphatricalcium phosphate (alpha-TCP) were investigated in a bone repair model using a rat model. Methods: The potential of alpha-TCP on bone repair was compared to autogenous bone grafting, and unfilled cavities were used as negative control. Surgical cavities were prepared and designated as test (T), implanted with alpha-TCP blocks; negative control (C - ), unfilled; and positive control (C + ), implanted with autogenous bone graft. Results were analyzed on postoperative days three, seven, 14, 21 and 60. Results: The histological analyses showed the following results. Postoperative day three: presence of inflammatory infiltrate, erythrocytes and proliferating fibroblasts in T, C - and C + samples. Day seven: extensive bone neoformation in groups T and C + , and beginning of alpha-TCP resorption by phagocytic cells. Days 14 and 21: osteoblastic activity in the three types of cavities. Day 60: In all samples, neoformed bone similar to surrounding bone. Moderate interruption on the ostectomized cortical bone. Conclusions: Bone neoformation is seen seven days after implantation of alpha-TCP and autogenous bone. Comparison of C - with T and C + samples showed that repair is faster in implanted cavities; on day 60, control groups presented almost complete bone repair. Alpha-TCP cement presents biocompatibility and osteotransductivity, besides stability, but 60 days after surgery the cavities were not closed.