Going forward and back : the complex evolutionary history of the GPx
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/266229 |
Resumo: | There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is still unclear if they came from a common GPx ancestor. In this study, we aimed to unveil how GPx evolved throughout different phyla. Based on our phylogenetic trees and sequence analyses, we propose that all GPx encoding genes share a monomeric common ancestor and that the SeCys amino acid was incorporated early in the evolution of the metazoan kingdom. In addition, classical GPx and the cysteine-exclusive GPx07 have been present since non-bilaterian animals, but they seem to have been lost throughout evolution in different phyla. Therefore, the birth-and-death of GPx family members (like in other oxidoreductase families) seems to be an ongoing process, occurring independently across different kingdoms and phyla. |
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Trenz, Thomaz StumpfDelaix, Camila LuizaZolet, Andreia Carina TurchettoZamocky, MarcelLazzarotto, FernandaMargis-Pinheiro, Márcia2023-10-26T03:38:38Z20212079-7737http://hdl.handle.net/10183/266229001152164There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is still unclear if they came from a common GPx ancestor. In this study, we aimed to unveil how GPx evolved throughout different phyla. Based on our phylogenetic trees and sequence analyses, we propose that all GPx encoding genes share a monomeric common ancestor and that the SeCys amino acid was incorporated early in the evolution of the metazoan kingdom. In addition, classical GPx and the cysteine-exclusive GPx07 have been present since non-bilaterian animals, but they seem to have been lost throughout evolution in different phyla. Therefore, the birth-and-death of GPx family members (like in other oxidoreductase families) seems to be an ongoing process, occurring independently across different kingdoms and phyla.application/pdfengBiology. Basel. Vol. 10, n. 11 (Nov. 2021), e1165, 12 p.EvoluçãoPeroxidase familySelenocysteineGoing forward and back : the complex evolutionary history of the GPxEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001152164.pdf.txt001152164.pdf.txtExtracted Texttext/plain55087http://www.lume.ufrgs.br/bitstream/10183/266229/2/001152164.pdf.txt30eb90aaa84eb0b05459f14dd0360486MD52ORIGINAL001152164.pdfTexto completo (inglês)application/pdf2734256http://www.lume.ufrgs.br/bitstream/10183/266229/1/001152164.pdf0c493de4f22efb1a4260676a1a80819eMD5110183/2662292023-10-27 03:27:21.705475oai:www.lume.ufrgs.br:10183/266229Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-27T06:27:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Going forward and back : the complex evolutionary history of the GPx |
title |
Going forward and back : the complex evolutionary history of the GPx |
spellingShingle |
Going forward and back : the complex evolutionary history of the GPx Trenz, Thomaz Stumpf Evolução Peroxidase family Selenocysteine |
title_short |
Going forward and back : the complex evolutionary history of the GPx |
title_full |
Going forward and back : the complex evolutionary history of the GPx |
title_fullStr |
Going forward and back : the complex evolutionary history of the GPx |
title_full_unstemmed |
Going forward and back : the complex evolutionary history of the GPx |
title_sort |
Going forward and back : the complex evolutionary history of the GPx |
author |
Trenz, Thomaz Stumpf |
author_facet |
Trenz, Thomaz Stumpf Delaix, Camila Luiza Zolet, Andreia Carina Turchetto Zamocky, Marcel Lazzarotto, Fernanda Margis-Pinheiro, Márcia |
author_role |
author |
author2 |
Delaix, Camila Luiza Zolet, Andreia Carina Turchetto Zamocky, Marcel Lazzarotto, Fernanda Margis-Pinheiro, Márcia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Trenz, Thomaz Stumpf Delaix, Camila Luiza Zolet, Andreia Carina Turchetto Zamocky, Marcel Lazzarotto, Fernanda Margis-Pinheiro, Márcia |
dc.subject.por.fl_str_mv |
Evolução |
topic |
Evolução Peroxidase family Selenocysteine |
dc.subject.eng.fl_str_mv |
Peroxidase family Selenocysteine |
description |
There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is still unclear if they came from a common GPx ancestor. In this study, we aimed to unveil how GPx evolved throughout different phyla. Based on our phylogenetic trees and sequence analyses, we propose that all GPx encoding genes share a monomeric common ancestor and that the SeCys amino acid was incorporated early in the evolution of the metazoan kingdom. In addition, classical GPx and the cysteine-exclusive GPx07 have been present since non-bilaterian animals, but they seem to have been lost throughout evolution in different phyla. Therefore, the birth-and-death of GPx family members (like in other oxidoreductase families) seems to be an ongoing process, occurring independently across different kingdoms and phyla. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2023-10-26T03:38:38Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/266229 |
dc.identifier.issn.pt_BR.fl_str_mv |
2079-7737 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001152164 |
identifier_str_mv |
2079-7737 001152164 |
url |
http://hdl.handle.net/10183/266229 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Biology. Basel. Vol. 10, n. 11 (Nov. 2021), e1165, 12 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
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UFRGS |
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Repositório Institucional da UFRGS |
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