Restriction-modification systems in Mycoplasma ssp
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/23397 |
Resumo: | Restriction and Modification (R-M) systems are present in all Mycoplasma species sequenced so far. The presence of these genes poses barriers to gene transfer and could protect the cell against phage infections. The number and types of R-M genes between different Mycoplasma species are variable, which is characteristic of a polymorphism. The majority of the CDSs code for Type III R-M systems and particularly for methyltransferase enzymes, which suggests that functions other than the protection against the invasion of heterologous DNA may exist. A possible function of these enzymes could be the protection against the invasion of other but similar R-M systems. In Mycoplasma hyopneumoniae strain J, three of the putative methyltransferase genes were clustered in a region forming a genomic island. Many R-M CDSs were mapped in the vicinity of transposable elements suggesting an association between these genes and reinforcing the idea of R-M systems as mobile selfish DNA. Also, many R-M genes present repeats within their coding sequences, indicating that their expression is under the control of phase variation mechanisms. Altogether, these data suggest that R-M systems are a remarkable characteristic of Mycoplasma species and are probably involved in the adaptation of these bacteria to different environmental conditions. |
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Brocchi, MarceloVasconcelos, Ana Tereza Ribeiro deZaha, Arnaldo2010-06-05T04:17:26Z20071415-4757http://hdl.handle.net/10183/23397000589096Restriction and Modification (R-M) systems are present in all Mycoplasma species sequenced so far. The presence of these genes poses barriers to gene transfer and could protect the cell against phage infections. The number and types of R-M genes between different Mycoplasma species are variable, which is characteristic of a polymorphism. The majority of the CDSs code for Type III R-M systems and particularly for methyltransferase enzymes, which suggests that functions other than the protection against the invasion of heterologous DNA may exist. A possible function of these enzymes could be the protection against the invasion of other but similar R-M systems. In Mycoplasma hyopneumoniae strain J, three of the putative methyltransferase genes were clustered in a region forming a genomic island. Many R-M CDSs were mapped in the vicinity of transposable elements suggesting an association between these genes and reinforcing the idea of R-M systems as mobile selfish DNA. Also, many R-M genes present repeats within their coding sequences, indicating that their expression is under the control of phase variation mechanisms. Altogether, these data suggest that R-M systems are a remarkable characteristic of Mycoplasma species and are probably involved in the adaptation of these bacteria to different environmental conditions.application/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 30, n. 1 suppl. (mar. 2007), p. 236-244GenomaGenéticaMycoplasmaRestriction-modification systemsGenomesRestriction-modification systems in Mycoplasma sspinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000589096.pdf000589096.pdfTexto completo (inglês)application/pdf81709http://www.lume.ufrgs.br/bitstream/10183/23397/1/000589096.pdf9c5f38f1542129a04ab9454b7ed2dc6fMD51TEXT000589096.pdf.txt000589096.pdf.txtExtracted Texttext/plain43358http://www.lume.ufrgs.br/bitstream/10183/23397/2/000589096.pdf.txtff11c3e4d915d1c1d79b806268a9a2aeMD52THUMBNAIL000589096.pdf.jpg000589096.pdf.jpgGenerated Thumbnailimage/jpeg1834http://www.lume.ufrgs.br/bitstream/10183/23397/3/000589096.pdf.jpg01017a7cfeff462ef2bf5d53fec45d30MD5310183/233972018-10-09 07:59:43.985oai:www.lume.ufrgs.br:10183/23397Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-09T10:59:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Restriction-modification systems in Mycoplasma ssp |
title |
Restriction-modification systems in Mycoplasma ssp |
spellingShingle |
Restriction-modification systems in Mycoplasma ssp Brocchi, Marcelo Genoma Genética Mycoplasma Restriction-modification systems Genomes |
title_short |
Restriction-modification systems in Mycoplasma ssp |
title_full |
Restriction-modification systems in Mycoplasma ssp |
title_fullStr |
Restriction-modification systems in Mycoplasma ssp |
title_full_unstemmed |
Restriction-modification systems in Mycoplasma ssp |
title_sort |
Restriction-modification systems in Mycoplasma ssp |
author |
Brocchi, Marcelo |
author_facet |
Brocchi, Marcelo Vasconcelos, Ana Tereza Ribeiro de Zaha, Arnaldo |
author_role |
author |
author2 |
Vasconcelos, Ana Tereza Ribeiro de Zaha, Arnaldo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Brocchi, Marcelo Vasconcelos, Ana Tereza Ribeiro de Zaha, Arnaldo |
dc.subject.por.fl_str_mv |
Genoma Genética Mycoplasma |
topic |
Genoma Genética Mycoplasma Restriction-modification systems Genomes |
dc.subject.eng.fl_str_mv |
Restriction-modification systems Genomes |
description |
Restriction and Modification (R-M) systems are present in all Mycoplasma species sequenced so far. The presence of these genes poses barriers to gene transfer and could protect the cell against phage infections. The number and types of R-M genes between different Mycoplasma species are variable, which is characteristic of a polymorphism. The majority of the CDSs code for Type III R-M systems and particularly for methyltransferase enzymes, which suggests that functions other than the protection against the invasion of heterologous DNA may exist. A possible function of these enzymes could be the protection against the invasion of other but similar R-M systems. In Mycoplasma hyopneumoniae strain J, three of the putative methyltransferase genes were clustered in a region forming a genomic island. Many R-M CDSs were mapped in the vicinity of transposable elements suggesting an association between these genes and reinforcing the idea of R-M systems as mobile selfish DNA. Also, many R-M genes present repeats within their coding sequences, indicating that their expression is under the control of phase variation mechanisms. Altogether, these data suggest that R-M systems are a remarkable characteristic of Mycoplasma species and are probably involved in the adaptation of these bacteria to different environmental conditions. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-06-05T04:17:26Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
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http://hdl.handle.net/10183/23397 |
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1415-4757 |
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000589096 |
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http://hdl.handle.net/10183/23397 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto. Vol. 30, n. 1 suppl. (mar. 2007), p. 236-244 |
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openAccess |
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