Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain

Detalhes bibliográficos
Autor(a) principal: Scheid, Taina
Data de Publicação: 2018
Outros Autores: Moraes, Maira Silmara de, Henriques, Thiago Pereira, Riffel, Ana Paula Konzen, Belló-Klein, Adriane, Von Poser, Gilsane Lino, Ethur, Eduardo Miranda, Partata, Wania Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/179632
Resumo: We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in themethanol fraction (MeF), which was administered intraperitoneally (20mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI. In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats. Catalase activity decreased only in salinetreated CCI rats for 10 days. Total thiols decreased in saline- andMeF-treated CCI rats. Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10. No change was found in hydrogen peroxide and lipid hydroperoxide. Open-field and elevated plus-maze tests and blood parameters of liver function did not change.Thus, theMeF from leaves of S. terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI.
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spelling Scheid, TainaMoraes, Maira Silmara deHenriques, Thiago PereiraRiffel, Ana Paula KonzenBelló-Klein, AdrianeVon Poser, Gilsane LinoEthur, Eduardo MirandaPartata, Wania Aparecida2018-06-22T02:29:11Z20181741-427Xhttp://hdl.handle.net/10183/179632001069641We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in themethanol fraction (MeF), which was administered intraperitoneally (20mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI. In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats. Catalase activity decreased only in salinetreated CCI rats for 10 days. Total thiols decreased in saline- andMeF-treated CCI rats. Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10. No change was found in hydrogen peroxide and lipid hydroperoxide. Open-field and elevated plus-maze tests and blood parameters of liver function did not change.Thus, theMeF from leaves of S. terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI.application/pdfengEvidence-based complementary and alternative medicine : eCAM. [New York]. Vol. 2018 (2018), ID 5783412, [11 p.]Schinus terebinthifoliusNeuralgiaAntioxidantesEffects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic painEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001069641.pdf001069641.pdfTexto completo (inglês)application/pdf2001944http://www.lume.ufrgs.br/bitstream/10183/179632/1/001069641.pdf584fd9656939937e41cb2bdbb2d7bc17MD51TEXT001069641.pdf.txt001069641.pdf.txtExtracted Texttext/plain53050http://www.lume.ufrgs.br/bitstream/10183/179632/2/001069641.pdf.txtcc116a58ade996bbdc99b3c7d078c945MD5210183/1796322018-06-23 03:30:53.786019oai:www.lume.ufrgs.br:10183/179632Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-06-23T06:30:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
title Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
spellingShingle Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
Scheid, Taina
Schinus terebinthifolius
Neuralgia
Antioxidantes
title_short Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
title_full Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
title_fullStr Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
title_full_unstemmed Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
title_sort Effects of methanol fraction from leaves of Schinus terebinthifolius raddi on nociception and spinal-cord oxidative biomarkers in rats with neuropathic pain
author Scheid, Taina
author_facet Scheid, Taina
Moraes, Maira Silmara de
Henriques, Thiago Pereira
Riffel, Ana Paula Konzen
Belló-Klein, Adriane
Von Poser, Gilsane Lino
Ethur, Eduardo Miranda
Partata, Wania Aparecida
author_role author
author2 Moraes, Maira Silmara de
Henriques, Thiago Pereira
Riffel, Ana Paula Konzen
Belló-Klein, Adriane
Von Poser, Gilsane Lino
Ethur, Eduardo Miranda
Partata, Wania Aparecida
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Scheid, Taina
Moraes, Maira Silmara de
Henriques, Thiago Pereira
Riffel, Ana Paula Konzen
Belló-Klein, Adriane
Von Poser, Gilsane Lino
Ethur, Eduardo Miranda
Partata, Wania Aparecida
dc.subject.por.fl_str_mv Schinus terebinthifolius
Neuralgia
Antioxidantes
topic Schinus terebinthifolius
Neuralgia
Antioxidantes
description We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius, a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in themethanol fraction (MeF), which was administered intraperitoneally (20mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI. In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats. Catalase activity decreased only in salinetreated CCI rats for 10 days. Total thiols decreased in saline- andMeF-treated CCI rats. Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10. No change was found in hydrogen peroxide and lipid hydroperoxide. Open-field and elevated plus-maze tests and blood parameters of liver function did not change.Thus, theMeF from leaves of S. terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-06-22T02:29:11Z
dc.date.issued.fl_str_mv 2018
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