Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21193 |
Resumo: | We studied the effects of infusion of nerve growth factor (NGF) into the hippocampus and entorhinal cortex of male Wistar rats (250-300 g, N = 11-13 per group) on inhibitory avoidance retention. In order to evaluate the modulation of entorhinal and hippocampal NGF in shortand long-term memory, animals were implanted with cannulae in the CA1 area of the dorsal hippocampus or entorhinal cortex and trained in one-trial step-down inhibitory avoidance (foot shock, 0.4 mA). Retention tests were carried out 1.5 h or 24 h after training to measure short- and long-term memory, respectively. Immediately after training, rats received 5 μl NGF (0.05, 0.5 or 5.0 ng) or saline per side into the CA1 area and entorhinal cortex. The correct position of the cannulae was confirmed by histological analysis. The highest dose of NGF (5.0 ng) into the hippocampus blocked short-term memory (P < 0.05), whereas the doses of 0.5 (P < 0.05) and 5.0 ng (P < 0.01) NGF enhanced long-term memory. NGF administration into the entorhinal cortex improved long-term memory at the dose of 5.0 ng (P < 0.05) and did not alter short-term memory. Taken as a whole, our results suggest a differential modulation by entorhinal and hippocampal NGF of short- and long-term memory. |
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Walz, RogerRoesler, RafaelReinke, AdalisaMartins, Márcio RodrigoQuevedo, João Luciano deIzquierdo, Ivan Antonio2010-04-24T04:15:40Z20050100-879Xhttp://hdl.handle.net/10183/21193000524147We studied the effects of infusion of nerve growth factor (NGF) into the hippocampus and entorhinal cortex of male Wistar rats (250-300 g, N = 11-13 per group) on inhibitory avoidance retention. In order to evaluate the modulation of entorhinal and hippocampal NGF in shortand long-term memory, animals were implanted with cannulae in the CA1 area of the dorsal hippocampus or entorhinal cortex and trained in one-trial step-down inhibitory avoidance (foot shock, 0.4 mA). Retention tests were carried out 1.5 h or 24 h after training to measure short- and long-term memory, respectively. Immediately after training, rats received 5 μl NGF (0.05, 0.5 or 5.0 ng) or saline per side into the CA1 area and entorhinal cortex. The correct position of the cannulae was confirmed by histological analysis. The highest dose of NGF (5.0 ng) into the hippocampus blocked short-term memory (P < 0.05), whereas the doses of 0.5 (P < 0.05) and 5.0 ng (P < 0.01) NGF enhanced long-term memory. NGF administration into the entorhinal cortex improved long-term memory at the dose of 5.0 ng (P < 0.05) and did not alter short-term memory. Taken as a whole, our results suggest a differential modulation by entorhinal and hippocampal NGF of short- and long-term memory.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 38, no. 1 (Jan. 2005), p. 55-58BioquímicaNerve growth factorHippocampusEntorhinal cortexShort- and long-term memoryInhibitory avoidanceRatDifferential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000524147.pdf000524147.pdfTexto completo (inglês)application/pdf473904http://www.lume.ufrgs.br/bitstream/10183/21193/1/000524147.pdf50736a59f4791fb33047d5fc192aed7bMD51TEXT000524147.pdf.txt000524147.pdf.txtExtracted Texttext/plain15498http://www.lume.ufrgs.br/bitstream/10183/21193/2/000524147.pdf.txt5904bf801f7d091481abb5ce30d1dc5dMD52THUMBNAIL000524147.pdf.jpg000524147.pdf.jpgGenerated Thumbnailimage/jpeg1805http://www.lume.ufrgs.br/bitstream/10183/21193/3/000524147.pdf.jpge0164ec2bdc04044e8e3557a5f40b682MD5310183/211932021-11-20 06:21:21.474922oai:www.lume.ufrgs.br:10183/21193Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T08:21:21Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
title |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
spellingShingle |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation Walz, Roger Bioquímica Nerve growth factor Hippocampus Entorhinal cortex Short- and long-term memory Inhibitory avoidance Rat |
title_short |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
title_full |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
title_fullStr |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
title_full_unstemmed |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
title_sort |
Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation |
author |
Walz, Roger |
author_facet |
Walz, Roger Roesler, Rafael Reinke, Adalisa Martins, Márcio Rodrigo Quevedo, João Luciano de Izquierdo, Ivan Antonio |
author_role |
author |
author2 |
Roesler, Rafael Reinke, Adalisa Martins, Márcio Rodrigo Quevedo, João Luciano de Izquierdo, Ivan Antonio |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Walz, Roger Roesler, Rafael Reinke, Adalisa Martins, Márcio Rodrigo Quevedo, João Luciano de Izquierdo, Ivan Antonio |
dc.subject.por.fl_str_mv |
Bioquímica |
topic |
Bioquímica Nerve growth factor Hippocampus Entorhinal cortex Short- and long-term memory Inhibitory avoidance Rat |
dc.subject.eng.fl_str_mv |
Nerve growth factor Hippocampus Entorhinal cortex Short- and long-term memory Inhibitory avoidance Rat |
description |
We studied the effects of infusion of nerve growth factor (NGF) into the hippocampus and entorhinal cortex of male Wistar rats (250-300 g, N = 11-13 per group) on inhibitory avoidance retention. In order to evaluate the modulation of entorhinal and hippocampal NGF in shortand long-term memory, animals were implanted with cannulae in the CA1 area of the dorsal hippocampus or entorhinal cortex and trained in one-trial step-down inhibitory avoidance (foot shock, 0.4 mA). Retention tests were carried out 1.5 h or 24 h after training to measure short- and long-term memory, respectively. Immediately after training, rats received 5 μl NGF (0.05, 0.5 or 5.0 ng) or saline per side into the CA1 area and entorhinal cortex. The correct position of the cannulae was confirmed by histological analysis. The highest dose of NGF (5.0 ng) into the hippocampus blocked short-term memory (P < 0.05), whereas the doses of 0.5 (P < 0.05) and 5.0 ng (P < 0.01) NGF enhanced long-term memory. NGF administration into the entorhinal cortex improved long-term memory at the dose of 5.0 ng (P < 0.05) and did not alter short-term memory. Taken as a whole, our results suggest a differential modulation by entorhinal and hippocampal NGF of short- and long-term memory. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:40Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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0100-879X |
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000524147 |
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0100-879X 000524147 |
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http://hdl.handle.net/10183/21193 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 38, no. 1 (Jan. 2005), p. 55-58 |
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openAccess |
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