A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/23398 |
Resumo: | Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (PEP), a major problem for the pig industry. The mechanisms of M. hyopneumoniae pathogenicity allow to predict the existence of several classes of virulence factors, whose study has been essentially restricted to the characterization of adhesion-related and major antigenic proteins. The now available complete sequences of the genomes of two pathogenic and one non-pathogenic strain of M. hyopneumoniae allowed to use a comparative genomics approach to putatively identify virulence genes. In this preliminary survey, we were able to identify 118 CDSs encoding putative virulence factors, based on specific criteria ranging from predicted cell surface location or variation between strains to previous functional studies showing antigenicity or involvement in host-pathogen interaction. This survey is expected to serve as a first step towards the functional characterization of new virulence genes/proteins that will be important not only for a better comprehension of M. hyopneumoniae biology, but also for the development of new and improved protocols for PEP vaccination, diagnosis and treatment. |
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Ferreira, Henrique BunselmeyerCastro, Luiza Amaral de2010-06-05T04:17:27Z20071415-4757http://hdl.handle.net/10183/23398000589105Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (PEP), a major problem for the pig industry. The mechanisms of M. hyopneumoniae pathogenicity allow to predict the existence of several classes of virulence factors, whose study has been essentially restricted to the characterization of adhesion-related and major antigenic proteins. The now available complete sequences of the genomes of two pathogenic and one non-pathogenic strain of M. hyopneumoniae allowed to use a comparative genomics approach to putatively identify virulence genes. In this preliminary survey, we were able to identify 118 CDSs encoding putative virulence factors, based on specific criteria ranging from predicted cell surface location or variation between strains to previous functional studies showing antigenicity or involvement in host-pathogen interaction. This survey is expected to serve as a first step towards the functional characterization of new virulence genes/proteins that will be important not only for a better comprehension of M. hyopneumoniae biology, but also for the development of new and improved protocols for PEP vaccination, diagnosis and treatment.application/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 30, n. 1 suppl. (mar. 2007), p. 245-255GenomaMycoplasma hyopneumoniaePorcine enzootic pneumoniaeVirulenceHost-pathogen interactionAntigenAdhesinA preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000589105.pdf000589105.pdfTexto completo (inglês)application/pdf96341http://www.lume.ufrgs.br/bitstream/10183/23398/1/000589105.pdf398fcfa243932b6d75f195478ff0c576MD51TEXT000589105.pdf.txt000589105.pdf.txtExtracted Texttext/plain56095http://www.lume.ufrgs.br/bitstream/10183/23398/2/000589105.pdf.txtdbc114b7019689fda04b0dd261e7ed43MD52THUMBNAIL000589105.pdf.jpg000589105.pdf.jpgGenerated Thumbnailimage/jpeg1792http://www.lume.ufrgs.br/bitstream/10183/23398/3/000589105.pdf.jpg50fe5d537f978b69a24d58026e222a7bMD5310183/233982018-10-09 07:59:44.537oai:www.lume.ufrgs.br:10183/23398Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-09T10:59:44Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
title |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
spellingShingle |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis Ferreira, Henrique Bunselmeyer Genoma Mycoplasma hyopneumoniae Porcine enzootic pneumoniae Virulence Host-pathogen interaction Antigen Adhesin |
title_short |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
title_full |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
title_fullStr |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
title_full_unstemmed |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
title_sort |
A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis |
author |
Ferreira, Henrique Bunselmeyer |
author_facet |
Ferreira, Henrique Bunselmeyer Castro, Luiza Amaral de |
author_role |
author |
author2 |
Castro, Luiza Amaral de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Ferreira, Henrique Bunselmeyer Castro, Luiza Amaral de |
dc.subject.por.fl_str_mv |
Genoma Mycoplasma hyopneumoniae |
topic |
Genoma Mycoplasma hyopneumoniae Porcine enzootic pneumoniae Virulence Host-pathogen interaction Antigen Adhesin |
dc.subject.eng.fl_str_mv |
Porcine enzootic pneumoniae Virulence Host-pathogen interaction Antigen Adhesin |
description |
Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (PEP), a major problem for the pig industry. The mechanisms of M. hyopneumoniae pathogenicity allow to predict the existence of several classes of virulence factors, whose study has been essentially restricted to the characterization of adhesion-related and major antigenic proteins. The now available complete sequences of the genomes of two pathogenic and one non-pathogenic strain of M. hyopneumoniae allowed to use a comparative genomics approach to putatively identify virulence genes. In this preliminary survey, we were able to identify 118 CDSs encoding putative virulence factors, based on specific criteria ranging from predicted cell surface location or variation between strains to previous functional studies showing antigenicity or involvement in host-pathogen interaction. This survey is expected to serve as a first step towards the functional characterization of new virulence genes/proteins that will be important not only for a better comprehension of M. hyopneumoniae biology, but also for the development of new and improved protocols for PEP vaccination, diagnosis and treatment. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-06-05T04:17:27Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/23398 |
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1415-4757 |
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000589105 |
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http://hdl.handle.net/10183/23398 |
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eng |
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eng |
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Genetics and molecular biology. Ribeirão Preto. Vol. 30, n. 1 suppl. (mar. 2007), p. 245-255 |
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openAccess |
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