Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.]
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/109887 |
Resumo: | Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. |
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Fagundes, Renato BorgesAbnet, Christian C.Strickland, Paul T.Kamangar, FarinRoth, Mark J.Taylor, Philip R.Dawsey, Sanford M.2015-02-10T02:17:26Z20061471-2407http://hdl.handle.net/10183/109887000569483Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression.application/pdfengBMC cancer. London. Vol. 6 (maio, 2006), p. 139 [1-7]Neoplasias esofágicasConsumo de bebidas alcoolicasPoluição por fumaça de tabacoTabagismoBiomarcadoresCarcinógenos ambientaisCocarcinogêneseHigher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.]Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000569483.pdf000569483.pdfTexto completo (inglês)application/pdf272278http://www.lume.ufrgs.br/bitstream/10183/109887/1/000569483.pdf3e54c9483bbdb2fdf3e58e3efc998197MD51TEXT000569483.pdf.txt000569483.pdf.txtExtracted Texttext/plain34450http://www.lume.ufrgs.br/bitstream/10183/109887/2/000569483.pdf.txtf02e1e1355d55e4da76aa680be04523fMD52THUMBNAIL000569483.pdf.jpg000569483.pdf.jpgGenerated Thumbnailimage/jpeg2105http://www.lume.ufrgs.br/bitstream/10183/109887/3/000569483.pdf.jpg2f1b7efe2c23fa832e421258ce8a46baMD5310183/1098872020-05-29 03:32:57.961723oai:www.lume.ufrgs.br:10183/109887Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-05-29T06:32:57Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
title |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
spellingShingle |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] Fagundes, Renato Borges Neoplasias esofágicas Consumo de bebidas alcoolicas Poluição por fumaça de tabaco Tabagismo Biomarcadores Carcinógenos ambientais Cocarcinogênese |
title_short |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
title_full |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
title_fullStr |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
title_full_unstemmed |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
title_sort |
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil Renato B. Fagundes ... [et al.] |
author |
Fagundes, Renato Borges |
author_facet |
Fagundes, Renato Borges Abnet, Christian C. Strickland, Paul T. Kamangar, Farin Roth, Mark J. Taylor, Philip R. Dawsey, Sanford M. |
author_role |
author |
author2 |
Abnet, Christian C. Strickland, Paul T. Kamangar, Farin Roth, Mark J. Taylor, Philip R. Dawsey, Sanford M. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fagundes, Renato Borges Abnet, Christian C. Strickland, Paul T. Kamangar, Farin Roth, Mark J. Taylor, Philip R. Dawsey, Sanford M. |
dc.subject.por.fl_str_mv |
Neoplasias esofágicas Consumo de bebidas alcoolicas Poluição por fumaça de tabaco Tabagismo Biomarcadores Carcinógenos ambientais Cocarcinogênese |
topic |
Neoplasias esofágicas Consumo de bebidas alcoolicas Poluição por fumaça de tabaco Tabagismo Biomarcadores Carcinógenos ambientais Cocarcinogênese |
description |
Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. Background: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. Methods: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2015-02-10T02:17:26Z |
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BMC cancer. London. Vol. 6 (maio, 2006), p. 139 [1-7] |
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