Evaluation of cell proliferation rate in non-dysplastic leukoplakias
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/61369 |
Resumo: | Objective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis. |
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Hildebrand, Laura de CamposCarrard, Vinícius CoelhoLauxen, Isabel da SilvaQuadros, Onofre Francisco deChaves, Anna Cecília MoraesSant'Ana Filho, Manoel2012-11-24T01:43:49Z2010http://hdl.handle.net/10183/61369000785187Objective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis.application/pdfengMedicina oral, patología oral y cirugía bucal. Valencia. Vol. 15, no. 2 (Mar. 2010), p. e328-e334Patologia bucalMucosa bucal : DoencasLeucoplasia bucalProliferação celularLeukoplakiaEpithelial dysplasiaAcanthosisHyperkeratosisAgNORCell proliferationEvaluation of cell proliferation rate in non-dysplastic leukoplakiasEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000785187.pdf000785187.pdfTexto completo (inglês)application/pdf415649http://www.lume.ufrgs.br/bitstream/10183/61369/1/000785187.pdf7fff0d9b4a37042390d20eb80c5454f0MD51TEXT000785187.pdf.txt000785187.pdf.txtExtracted Texttext/plain27424http://www.lume.ufrgs.br/bitstream/10183/61369/2/000785187.pdf.txtb5c13b70124a94369622b8ced671c4caMD52THUMBNAIL000785187.pdf.jpg000785187.pdf.jpgGenerated Thumbnailimage/jpeg1984http://www.lume.ufrgs.br/bitstream/10183/61369/3/000785187.pdf.jpg1583ebb87f9305127c678f35c00aa63cMD5310183/613692018-10-16 08:02:43.358oai:www.lume.ufrgs.br:10183/61369Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-16T11:02:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
title |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
spellingShingle |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias Hildebrand, Laura de Campos Patologia bucal Mucosa bucal : Doencas Leucoplasia bucal Proliferação celular Leukoplakia Epithelial dysplasia Acanthosis Hyperkeratosis AgNOR Cell proliferation |
title_short |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
title_full |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
title_fullStr |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
title_full_unstemmed |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
title_sort |
Evaluation of cell proliferation rate in non-dysplastic leukoplakias |
author |
Hildebrand, Laura de Campos |
author_facet |
Hildebrand, Laura de Campos Carrard, Vinícius Coelho Lauxen, Isabel da Silva Quadros, Onofre Francisco de Chaves, Anna Cecília Moraes Sant'Ana Filho, Manoel |
author_role |
author |
author2 |
Carrard, Vinícius Coelho Lauxen, Isabel da Silva Quadros, Onofre Francisco de Chaves, Anna Cecília Moraes Sant'Ana Filho, Manoel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Hildebrand, Laura de Campos Carrard, Vinícius Coelho Lauxen, Isabel da Silva Quadros, Onofre Francisco de Chaves, Anna Cecília Moraes Sant'Ana Filho, Manoel |
dc.subject.por.fl_str_mv |
Patologia bucal Mucosa bucal : Doencas Leucoplasia bucal Proliferação celular |
topic |
Patologia bucal Mucosa bucal : Doencas Leucoplasia bucal Proliferação celular Leukoplakia Epithelial dysplasia Acanthosis Hyperkeratosis AgNOR Cell proliferation |
dc.subject.eng.fl_str_mv |
Leukoplakia Epithelial dysplasia Acanthosis Hyperkeratosis AgNOR Cell proliferation |
description |
Objective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2012-11-24T01:43:49Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/61369 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000785187 |
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http://hdl.handle.net/10183/61369 |
identifier_str_mv |
000785187 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Medicina oral, patología oral y cirugía bucal. Valencia. Vol. 15, no. 2 (Mar. 2010), p. e328-e334 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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