Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/218866 |
Resumo: | Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce information on the effects of maternal histidinemia on their progeny, we investigated various parameters of oxidative stress in brain cortex and hippocampus of the offspring from female rats that received histidine (0.5 mg/g of body weight) in the course of pregnancy and lactation. At 21 days of age we found a significant increase of thiobarbituric acid reactive substances (TBARS), 20 ,70 -dihydrodichlorofluorescein oxidation, superoxide dismutase (SOD) activity, catalase (CAT) activity, total sulfhydryls and glutathione (GSH) content in cerebral cortex and hippocampus. We also verified that at 60 days of age, GSH, SOD and total sulfhydryls returned to normal levels in brain cortex, while the other parameters decreased in the same structure. In the hippocampus, at 60 days of age GSH returned to normal levels, CAT persisted elevated and the other parameters decreased. These results indicate that histidine administration to female rats can induce oxidative stress in the brain from the offspring, which partially recovers 40 days after breastfeeding stopped. |
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Rojas, Denise BertinGemelli, TaniseAndrade, Rodrigo Binkowski deCampos, Aline GuimarãesDutra Filho, Carlos SeveroWannmacher, Clovis Milton Duval2021-03-15T04:08:10Z20120364-3190http://hdl.handle.net/10183/218866000905599Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce information on the effects of maternal histidinemia on their progeny, we investigated various parameters of oxidative stress in brain cortex and hippocampus of the offspring from female rats that received histidine (0.5 mg/g of body weight) in the course of pregnancy and lactation. At 21 days of age we found a significant increase of thiobarbituric acid reactive substances (TBARS), 20 ,70 -dihydrodichlorofluorescein oxidation, superoxide dismutase (SOD) activity, catalase (CAT) activity, total sulfhydryls and glutathione (GSH) content in cerebral cortex and hippocampus. We also verified that at 60 days of age, GSH, SOD and total sulfhydryls returned to normal levels in brain cortex, while the other parameters decreased in the same structure. In the hippocampus, at 60 days of age GSH returned to normal levels, CAT persisted elevated and the other parameters decreased. These results indicate that histidine administration to female rats can induce oxidative stress in the brain from the offspring, which partially recovers 40 days after breastfeeding stopped.application/pdfengNeurochemical research. New York, NY. Vol. 37, no. 5 (May 2012), p. 1031-1036HistidinaEstresse oxidativoHipocampoCórtex cerebralHistidineMaternal histidinemiaOxidative stressHippocampusAdministration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspringEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000905599.pdf.txt000905599.pdf.txtExtracted Texttext/plain0http://www.lume.ufrgs.br/bitstream/10183/218866/2/000905599.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD52ORIGINAL000905599.pdfTexto completo (inglês)application/pdf2249055http://www.lume.ufrgs.br/bitstream/10183/218866/1/000905599.pdfd983d691d3ec861e4cffc60d7b290392MD5110183/2188662021-04-13 04:18:26.364424oai:www.lume.ufrgs.br:10183/218866Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-04-13T07:18:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
title |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
spellingShingle |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring Rojas, Denise Bertin Histidina Estresse oxidativo Hipocampo Córtex cerebral Histidine Maternal histidinemia Oxidative stress Hippocampus |
title_short |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
title_full |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
title_fullStr |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
title_full_unstemmed |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
title_sort |
Administration of histidine to female rats induces changes in oxidative status in cortex and hippocampus of the offspring |
author |
Rojas, Denise Bertin |
author_facet |
Rojas, Denise Bertin Gemelli, Tanise Andrade, Rodrigo Binkowski de Campos, Aline Guimarães Dutra Filho, Carlos Severo Wannmacher, Clovis Milton Duval |
author_role |
author |
author2 |
Gemelli, Tanise Andrade, Rodrigo Binkowski de Campos, Aline Guimarães Dutra Filho, Carlos Severo Wannmacher, Clovis Milton Duval |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rojas, Denise Bertin Gemelli, Tanise Andrade, Rodrigo Binkowski de Campos, Aline Guimarães Dutra Filho, Carlos Severo Wannmacher, Clovis Milton Duval |
dc.subject.por.fl_str_mv |
Histidina Estresse oxidativo Hipocampo Córtex cerebral |
topic |
Histidina Estresse oxidativo Hipocampo Córtex cerebral Histidine Maternal histidinemia Oxidative stress Hippocampus |
dc.subject.eng.fl_str_mv |
Histidine Maternal histidinemia Oxidative stress Hippocampus |
description |
Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce information on the effects of maternal histidinemia on their progeny, we investigated various parameters of oxidative stress in brain cortex and hippocampus of the offspring from female rats that received histidine (0.5 mg/g of body weight) in the course of pregnancy and lactation. At 21 days of age we found a significant increase of thiobarbituric acid reactive substances (TBARS), 20 ,70 -dihydrodichlorofluorescein oxidation, superoxide dismutase (SOD) activity, catalase (CAT) activity, total sulfhydryls and glutathione (GSH) content in cerebral cortex and hippocampus. We also verified that at 60 days of age, GSH, SOD and total sulfhydryls returned to normal levels in brain cortex, while the other parameters decreased in the same structure. In the hippocampus, at 60 days of age GSH returned to normal levels, CAT persisted elevated and the other parameters decreased. These results indicate that histidine administration to female rats can induce oxidative stress in the brain from the offspring, which partially recovers 40 days after breastfeeding stopped. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2021-03-15T04:08:10Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/218866 |
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0364-3190 |
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000905599 |
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http://hdl.handle.net/10183/218866 |
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eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Neurochemical research. New York, NY. Vol. 37, no. 5 (May 2012), p. 1031-1036 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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