Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/211627 |
Resumo: | Introduction Studies have revealed that glycated albumin (GA) is a useful alternative to HbA1c under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus (DM). Thus, the aim of this study was to assess the clinical utility of GA in diagnosis of DM. Materials and methods This diagnostic test accuracy study was performed in 242 Brazilian individuals referred for OGTT in a tertiary university hospital. ROC curves were used to access the performance of GA and HbA1c in the diagnosis of DM by oral glucose tolerance test (OGTT). Results OGTT, HbA1c and GA were performed in all 242 participants (40.5% male, age 54.4 ± 13.0 years [mean ± SD], body mass index 28.9 ± 6.3 kg/m2 ). DM by OGTT was detected in 31.8% of individuals. The equilibrium threshold value of GA �14.8% showed sensitivity of 64.9% and specificity of 65.5% for the diagnosis of DM. The AUC for GA [0.703 (95% CI 0.631–0.775)] was lower than for HbA1c [0.802 (95% CI 0.740–0.864)], p = 0.028. A GA value of 16.8% had similar accuracy for detecting DM as defined by HbA1c �6.5% (48 mmol/mol) with sensitivity of 31.2% and specificity of 93.3% for both tests. However, GA detects different subjects from those detected by HbA1c and OGTT. Conclusions GA detected different individuals with DM from those detected by HbA1c, though it showed overall diagnostic accuracy similar to HbA1c in the diagnosis of DM. Therefore, GA should be used as an additional test rather than an alternative to HbA1c or OGTT and its use as the sole DM diagnostic test should be interpreted with caution. |
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Chume, Fernando ChimelaBerdichevski, Mayana Kieling HernandezFreitas, Priscila Aparecida CorreaCavagnolli, GabrielaCamargo, Joiza Lins2020-07-09T03:42:07Z20191932-6203http://hdl.handle.net/10183/211627001114923Introduction Studies have revealed that glycated albumin (GA) is a useful alternative to HbA1c under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus (DM). Thus, the aim of this study was to assess the clinical utility of GA in diagnosis of DM. Materials and methods This diagnostic test accuracy study was performed in 242 Brazilian individuals referred for OGTT in a tertiary university hospital. ROC curves were used to access the performance of GA and HbA1c in the diagnosis of DM by oral glucose tolerance test (OGTT). Results OGTT, HbA1c and GA were performed in all 242 participants (40.5% male, age 54.4 ± 13.0 years [mean ± SD], body mass index 28.9 ± 6.3 kg/m2 ). DM by OGTT was detected in 31.8% of individuals. The equilibrium threshold value of GA �14.8% showed sensitivity of 64.9% and specificity of 65.5% for the diagnosis of DM. The AUC for GA [0.703 (95% CI 0.631–0.775)] was lower than for HbA1c [0.802 (95% CI 0.740–0.864)], p = 0.028. A GA value of 16.8% had similar accuracy for detecting DM as defined by HbA1c �6.5% (48 mmol/mol) with sensitivity of 31.2% and specificity of 93.3% for both tests. However, GA detects different subjects from those detected by HbA1c and OGTT. Conclusions GA detected different individuals with DM from those detected by HbA1c, though it showed overall diagnostic accuracy similar to HbA1c in the diagnosis of DM. Therefore, GA should be used as an additional test rather than an alternative to HbA1c or OGTT and its use as the sole DM diagnostic test should be interpreted with caution.application/pdfengPloS one. San Francisco. Vol. 14, no. 12 (Dec. 2019), e0227065, 13 p.Diabetes mellitus tipo 2Albumina séricaGlucoseHemoglobinas glicadasDiagnósticoTeste de tolerância à glucoseHipoglicemiaGlycated albumin as a diagnostic tool in diabetes : an alternative or an additional test?Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001114923.pdf.txt001114923.pdf.txtExtracted Texttext/plain42957http://www.lume.ufrgs.br/bitstream/10183/211627/2/001114923.pdf.txtda839f49e3facf9c47ee8026b582f55eMD52ORIGINAL001114923.pdfTexto completo (inglês)application/pdf1624515http://www.lume.ufrgs.br/bitstream/10183/211627/1/001114923.pdf2398e0c56adfeed7deb8a224daba4a4bMD5110183/2116272024-03-13 05:04:00.593828oai:www.lume.ufrgs.br:10183/211627Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-03-13T08:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
title |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
spellingShingle |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? Chume, Fernando Chimela Diabetes mellitus tipo 2 Albumina sérica Glucose Hemoglobinas glicadas Diagnóstico Teste de tolerância à glucose Hipoglicemia |
title_short |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
title_full |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
title_fullStr |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
title_full_unstemmed |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
title_sort |
Glycated albumin as a diagnostic tool in diabetes : an alternative or an additional test? |
author |
Chume, Fernando Chimela |
author_facet |
Chume, Fernando Chimela Berdichevski, Mayana Kieling Hernandez Freitas, Priscila Aparecida Correa Cavagnolli, Gabriela Camargo, Joiza Lins |
author_role |
author |
author2 |
Berdichevski, Mayana Kieling Hernandez Freitas, Priscila Aparecida Correa Cavagnolli, Gabriela Camargo, Joiza Lins |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Chume, Fernando Chimela Berdichevski, Mayana Kieling Hernandez Freitas, Priscila Aparecida Correa Cavagnolli, Gabriela Camargo, Joiza Lins |
dc.subject.por.fl_str_mv |
Diabetes mellitus tipo 2 Albumina sérica Glucose Hemoglobinas glicadas Diagnóstico Teste de tolerância à glucose Hipoglicemia |
topic |
Diabetes mellitus tipo 2 Albumina sérica Glucose Hemoglobinas glicadas Diagnóstico Teste de tolerância à glucose Hipoglicemia |
description |
Introduction Studies have revealed that glycated albumin (GA) is a useful alternative to HbA1c under conditions wherein the latter does not reflect glycaemic status accurately. Until now, there are few studies with non-Asians subjects that report on the validity of GA test in diagnosis of type 2 diabetes mellitus (DM). Thus, the aim of this study was to assess the clinical utility of GA in diagnosis of DM. Materials and methods This diagnostic test accuracy study was performed in 242 Brazilian individuals referred for OGTT in a tertiary university hospital. ROC curves were used to access the performance of GA and HbA1c in the diagnosis of DM by oral glucose tolerance test (OGTT). Results OGTT, HbA1c and GA were performed in all 242 participants (40.5% male, age 54.4 ± 13.0 years [mean ± SD], body mass index 28.9 ± 6.3 kg/m2 ). DM by OGTT was detected in 31.8% of individuals. The equilibrium threshold value of GA �14.8% showed sensitivity of 64.9% and specificity of 65.5% for the diagnosis of DM. The AUC for GA [0.703 (95% CI 0.631–0.775)] was lower than for HbA1c [0.802 (95% CI 0.740–0.864)], p = 0.028. A GA value of 16.8% had similar accuracy for detecting DM as defined by HbA1c �6.5% (48 mmol/mol) with sensitivity of 31.2% and specificity of 93.3% for both tests. However, GA detects different subjects from those detected by HbA1c and OGTT. Conclusions GA detected different individuals with DM from those detected by HbA1c, though it showed overall diagnostic accuracy similar to HbA1c in the diagnosis of DM. Therefore, GA should be used as an additional test rather than an alternative to HbA1c or OGTT and its use as the sole DM diagnostic test should be interpreted with caution. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
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2020-07-09T03:42:07Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/211627 |
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1932-6203 |
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001114923 |
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http://hdl.handle.net/10183/211627 |
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eng |
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PloS one. San Francisco. Vol. 14, no. 12 (Dec. 2019), e0227065, 13 p. |
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