Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values

Detalhes bibliográficos
Autor(a) principal: Paludo, Francis Jackson de Oliveira
Data de Publicação: 2021
Outros Autores: Pasquali, Matheus Augusto de Bittencourt, Vargas, Amanda Rodrigues de, Oliveira, Iara Bezerra de, Gonçalves, Luzia Valberligia Batista, Gelain, Daniel Pens, Moreira, Jose Claudio Fonseca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/232636
Resumo: Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that appears phylogenetically conserved. However, functional Sod2 polymorphisms have been studied, and the specific polymorphisms are related to activity alterations of the SOD2 enzyme. An example of a polymorphism of SOD2 is Val16Ala (rs4880), which has been identified in exon 2 of the human Sod2 gene. This polymorphism is recognized as a single nucleotide polymorphism (SNP) and alters the conformation of SOD2. Additionally, recent studies have shown that the Ala16 Val polymorphism in Sod2 can be related to different pathological diseases. In these terms, the objective of the present study was to evaluate whether the polymorphism of SOD2 in Val16Ala (rs4880) influences the motility and vigor of X- and Y-bearing sperm at different pH values promoting sperm selection. We found that polymorphism rs4880 at normal pH conditions can result in alterations in the activity of superoxide dismutase in the sperm through different assay analyses. Moreover, compelling modulation evidence indicates that this effect could also mediate seminal plasma redox alterations and consequently can play an important role in sperm physiology, fertilization, and postfertilization.
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spelling Paludo, Francis Jackson de OliveiraPasquali, Matheus Augusto de BittencourtVargas, Amanda Rodrigues deOliveira, Iara Bezerra deGonçalves, Luzia Valberligia BatistaGelain, Daniel PensMoreira, Jose Claudio Fonseca2021-12-07T04:31:16Z20211950-6007http://hdl.handle.net/10183/232636001133970Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that appears phylogenetically conserved. However, functional Sod2 polymorphisms have been studied, and the specific polymorphisms are related to activity alterations of the SOD2 enzyme. An example of a polymorphism of SOD2 is Val16Ala (rs4880), which has been identified in exon 2 of the human Sod2 gene. This polymorphism is recognized as a single nucleotide polymorphism (SNP) and alters the conformation of SOD2. Additionally, recent studies have shown that the Ala16 Val polymorphism in Sod2 can be related to different pathological diseases. In these terms, the objective of the present study was to evaluate whether the polymorphism of SOD2 in Val16Ala (rs4880) influences the motility and vigor of X- and Y-bearing sperm at different pH values promoting sperm selection. We found that polymorphism rs4880 at normal pH conditions can result in alterations in the activity of superoxide dismutase in the sperm through different assay analyses. Moreover, compelling modulation evidence indicates that this effect could also mediate seminal plasma redox alterations and consequently can play an important role in sperm physiology, fertilization, and postfertilization.application/pdfengBiomedicine & pharmacotherapy. Paris. Vol. 142 (Oct. 2021), 111993, 7 p.Superóxido dismutasePolimorfismo genéticoEspermatozóidesMotilidade espermáticaFertilizationSpermSuperoxide dismutasers4880PolymorphismInfluences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH valuesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001133970.pdf.txt001133970.pdf.txtExtracted Texttext/plain40177http://www.lume.ufrgs.br/bitstream/10183/232636/2/001133970.pdf.txte8f89ac4bd947293b755ba24226b3de6MD52ORIGINAL001133970.pdfTexto completo (inglês)application/pdf662086http://www.lume.ufrgs.br/bitstream/10183/232636/1/001133970.pdfb065852a87d58af134e2b521e3b73c86MD5110183/2326362024-03-09 05:02:25.820723oai:www.lume.ufrgs.br:10183/232636Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-03-09T08:02:25Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
title Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
spellingShingle Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
Paludo, Francis Jackson de Oliveira
Superóxido dismutase
Polimorfismo genético
Espermatozóides
Motilidade espermática
Fertilization
Sperm
Superoxide dismutase
rs4880
Polymorphism
title_short Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
title_full Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
title_fullStr Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
title_full_unstemmed Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
title_sort Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
author Paludo, Francis Jackson de Oliveira
author_facet Paludo, Francis Jackson de Oliveira
Pasquali, Matheus Augusto de Bittencourt
Vargas, Amanda Rodrigues de
Oliveira, Iara Bezerra de
Gonçalves, Luzia Valberligia Batista
Gelain, Daniel Pens
Moreira, Jose Claudio Fonseca
author_role author
author2 Pasquali, Matheus Augusto de Bittencourt
Vargas, Amanda Rodrigues de
Oliveira, Iara Bezerra de
Gonçalves, Luzia Valberligia Batista
Gelain, Daniel Pens
Moreira, Jose Claudio Fonseca
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paludo, Francis Jackson de Oliveira
Pasquali, Matheus Augusto de Bittencourt
Vargas, Amanda Rodrigues de
Oliveira, Iara Bezerra de
Gonçalves, Luzia Valberligia Batista
Gelain, Daniel Pens
Moreira, Jose Claudio Fonseca
dc.subject.por.fl_str_mv Superóxido dismutase
Polimorfismo genético
Espermatozóides
Motilidade espermática
topic Superóxido dismutase
Polimorfismo genético
Espermatozóides
Motilidade espermática
Fertilization
Sperm
Superoxide dismutase
rs4880
Polymorphism
dc.subject.eng.fl_str_mv Fertilization
Sperm
Superoxide dismutase
rs4880
Polymorphism
description Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that appears phylogenetically conserved. However, functional Sod2 polymorphisms have been studied, and the specific polymorphisms are related to activity alterations of the SOD2 enzyme. An example of a polymorphism of SOD2 is Val16Ala (rs4880), which has been identified in exon 2 of the human Sod2 gene. This polymorphism is recognized as a single nucleotide polymorphism (SNP) and alters the conformation of SOD2. Additionally, recent studies have shown that the Ala16 Val polymorphism in Sod2 can be related to different pathological diseases. In these terms, the objective of the present study was to evaluate whether the polymorphism of SOD2 in Val16Ala (rs4880) influences the motility and vigor of X- and Y-bearing sperm at different pH values promoting sperm selection. We found that polymorphism rs4880 at normal pH conditions can result in alterations in the activity of superoxide dismutase in the sperm through different assay analyses. Moreover, compelling modulation evidence indicates that this effect could also mediate seminal plasma redox alterations and consequently can play an important role in sperm physiology, fertilization, and postfertilization.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-07T04:31:16Z
dc.date.issued.fl_str_mv 2021
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/232636
dc.identifier.issn.pt_BR.fl_str_mv 1950-6007
dc.identifier.nrb.pt_BR.fl_str_mv 001133970
identifier_str_mv 1950-6007
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url http://hdl.handle.net/10183/232636
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Biomedicine & pharmacotherapy. Paris. Vol. 142 (Oct. 2021), 111993, 7 p.
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
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instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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