Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/259920 |
Resumo: | Carbonic anhydrase inhibitors, such as acetazolamide, are widely used in the treatment of open-angle glaucoma. Severe metabolic acidosis is a rare complication of acetazolamide use, and life-threatening acidosis occurs most commonly in elderly patients, in patients with advanced renal failure, and in patients with diabetes. We describe an unusual case of an elderly patient with diabetic nephropathy and chronic renal failure who presented to the emergency department with severe metabolic acidosis and coma after exposure to high doses of acetazolamide in the postoperative period of ophthalmic surgery. As symptoms of acetazolamide intoxication and uremia are similar, high suspicion is required to detect excessive plasma drug concentrations and intoxication in patients presenting with concomitant uremia. Clinical symptoms are potentially reversible with prompt diagnosis and treatment, including supportive treatment, bicarbonate therapy, and renal replacement therapy. Hemodialysis is particularly helpful in the management of acetazolamide overdose as the medication is dialyzable. |
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Kerber, Juliana MariaMello, Juliana Dias deMoura, Karolinny Borinelli de AquinoSilva, Gustavo Cardoso daWawrzeniak, Iuri ChristmannRech, Tatiana Helena2023-07-04T03:50:54Z20222090-6439http://hdl.handle.net/10183/259920001169168Carbonic anhydrase inhibitors, such as acetazolamide, are widely used in the treatment of open-angle glaucoma. Severe metabolic acidosis is a rare complication of acetazolamide use, and life-threatening acidosis occurs most commonly in elderly patients, in patients with advanced renal failure, and in patients with diabetes. We describe an unusual case of an elderly patient with diabetic nephropathy and chronic renal failure who presented to the emergency department with severe metabolic acidosis and coma after exposure to high doses of acetazolamide in the postoperative period of ophthalmic surgery. As symptoms of acetazolamide intoxication and uremia are similar, high suspicion is required to detect excessive plasma drug concentrations and intoxication in patients presenting with concomitant uremia. Clinical symptoms are potentially reversible with prompt diagnosis and treatment, including supportive treatment, bicarbonate therapy, and renal replacement therapy. Hemodialysis is particularly helpful in the management of acetazolamide overdose as the medication is dialyzable.application/pdfengCase reports in critical care. New York, NY. Vol. 2020 (Jan. 2020), 3764972, 5 p.AcetazolamidaCOVID-19Diabetes mellitusAcetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgeryEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169168.pdf.txt001169168.pdf.txtExtracted Texttext/plain16790http://www.lume.ufrgs.br/bitstream/10183/259920/2/001169168.pdf.txtd37075b5570995b23729b673b5c5fd39MD52ORIGINAL001169168.pdfTexto completo (inglês)application/pdf916290http://www.lume.ufrgs.br/bitstream/10183/259920/1/001169168.pdfdf91ce62bfe900bc9792643fc590e450MD5110183/2599202023-07-05 03:49:00.131431oai:www.lume.ufrgs.br:10183/259920Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-05T06:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
title |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
spellingShingle |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery Kerber, Juliana Maria Acetazolamida COVID-19 Diabetes mellitus |
title_short |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
title_full |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
title_fullStr |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
title_full_unstemmed |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
title_sort |
Acetazolamide intoxication in an elderly patient with diabetes and chronic renal failure after cataract surgery |
author |
Kerber, Juliana Maria |
author_facet |
Kerber, Juliana Maria Mello, Juliana Dias de Moura, Karolinny Borinelli de Aquino Silva, Gustavo Cardoso da Wawrzeniak, Iuri Christmann Rech, Tatiana Helena |
author_role |
author |
author2 |
Mello, Juliana Dias de Moura, Karolinny Borinelli de Aquino Silva, Gustavo Cardoso da Wawrzeniak, Iuri Christmann Rech, Tatiana Helena |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Kerber, Juliana Maria Mello, Juliana Dias de Moura, Karolinny Borinelli de Aquino Silva, Gustavo Cardoso da Wawrzeniak, Iuri Christmann Rech, Tatiana Helena |
dc.subject.por.fl_str_mv |
Acetazolamida COVID-19 Diabetes mellitus |
topic |
Acetazolamida COVID-19 Diabetes mellitus |
description |
Carbonic anhydrase inhibitors, such as acetazolamide, are widely used in the treatment of open-angle glaucoma. Severe metabolic acidosis is a rare complication of acetazolamide use, and life-threatening acidosis occurs most commonly in elderly patients, in patients with advanced renal failure, and in patients with diabetes. We describe an unusual case of an elderly patient with diabetic nephropathy and chronic renal failure who presented to the emergency department with severe metabolic acidosis and coma after exposure to high doses of acetazolamide in the postoperative period of ophthalmic surgery. As symptoms of acetazolamide intoxication and uremia are similar, high suspicion is required to detect excessive plasma drug concentrations and intoxication in patients presenting with concomitant uremia. Clinical symptoms are potentially reversible with prompt diagnosis and treatment, including supportive treatment, bicarbonate therapy, and renal replacement therapy. Hemodialysis is particularly helpful in the management of acetazolamide overdose as the medication is dialyzable. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
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2023-07-04T03:50:54Z |
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Estrangeiro info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10183/259920 |
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2090-6439 |
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001169168 |
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http://hdl.handle.net/10183/259920 |
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eng |
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Case reports in critical care. New York, NY. Vol. 2020 (Jan. 2020), 3764972, 5 p. |
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