What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/248394 |
Resumo: | Background: Genetic factors along with inadequate lifestyle habits are associated with the development of cardiometabolic alterations. Thus, the present study aimed to examine the role of sedentary behavior on the relationship between rs9939609 polymorphism (fat mass and obesity-associated gene-FTO) and cardiometabolic risk score according to cardiorespiratory ftness (CRF) levels in children and adolescents. Methods: A cross-sectional study with 1215 children and adolescents (692 girls), aged between 6 and 17 years. Screen time as a marker of sedentary behavior was evaluated through a self-reported questionnaire and CRF was estimated using the 6-min walking and running test. The genotyping of the FTO rs9939609 polymorphism was performed using a real-time polymerase chain reaction. Clustered cardiometabolic risk score (cMetS) was calculated by summing z-scores of total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, glucose, systolic blood pressure, and waist circumference, and dividing it by fve. Moderation analyses were tested using multiple linear regression models. Results: The coefcient of the interaction term of FTO (rs9939609) and screen time indicated that screen time was a signifcant moderator on the relationship between FTO rs9939609 polymorphism and cMetS (p=0.047) in children and adolescents classifed with low CRF (β=0.001; 95% CI=0.001; 0.002). It was observed a signifcant association between genotype risk (AA) of FTO polymorphism and cMetS, in participants that spent more than 378 min a day in front of screen-based devices (β=0.203; 95% CI=0.000; 0.405). No interaction term was found for those with high CRF. Conclusions: High sedentary behavior seems to infuence the relationship between genetic predisposition to obesity and cardiometabolic risk factors in children and adolescents with low CRF. |
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Sehn, Ana PaulaBrand, CarolineSilveira, João Francisco de CastroAndersen, Lars BoGaya, Anelise ReisTodendi, Pâmela FerreiraValim, Andréia Rosane de MouraReuter, Cézane Priscila2022-09-01T05:00:14Z20221471-2261http://hdl.handle.net/10183/248394001145960Background: Genetic factors along with inadequate lifestyle habits are associated with the development of cardiometabolic alterations. Thus, the present study aimed to examine the role of sedentary behavior on the relationship between rs9939609 polymorphism (fat mass and obesity-associated gene-FTO) and cardiometabolic risk score according to cardiorespiratory ftness (CRF) levels in children and adolescents. Methods: A cross-sectional study with 1215 children and adolescents (692 girls), aged between 6 and 17 years. Screen time as a marker of sedentary behavior was evaluated through a self-reported questionnaire and CRF was estimated using the 6-min walking and running test. The genotyping of the FTO rs9939609 polymorphism was performed using a real-time polymerase chain reaction. Clustered cardiometabolic risk score (cMetS) was calculated by summing z-scores of total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, glucose, systolic blood pressure, and waist circumference, and dividing it by fve. Moderation analyses were tested using multiple linear regression models. Results: The coefcient of the interaction term of FTO (rs9939609) and screen time indicated that screen time was a signifcant moderator on the relationship between FTO rs9939609 polymorphism and cMetS (p=0.047) in children and adolescents classifed with low CRF (β=0.001; 95% CI=0.001; 0.002). It was observed a signifcant association between genotype risk (AA) of FTO polymorphism and cMetS, in participants that spent more than 378 min a day in front of screen-based devices (β=0.203; 95% CI=0.000; 0.405). No interaction term was found for those with high CRF. Conclusions: High sedentary behavior seems to infuence the relationship between genetic predisposition to obesity and cardiometabolic risk factors in children and adolescents with low CRF.application/pdfengBMC Cardiovascular Disorders. London. v. 22 (2022), 92, p. 1-9.Comportamento sedentárioObesidadeAptidão cardiorrespiratóriaCriançasAdolescentesPolimorfismoSíndrome metabólicaScreen timeCardiorespiratory ftnessFTO polymorphismMetabolic syndromeChildhoodYoungWhat is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score?Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001145960.pdf.txt001145960.pdf.txtExtracted Texttext/plain42926http://www.lume.ufrgs.br/bitstream/10183/248394/2/001145960.pdf.txteb15281d7d820fee1e505610c50e6787MD52ORIGINAL001145960.pdfTexto completo (inglês)application/pdf1088069http://www.lume.ufrgs.br/bitstream/10183/248394/1/001145960.pdf3d986326bf137d6a8ad8062a95e4a12bMD5110183/2483942022-09-02 04:59:49.418422oai:www.lume.ufrgs.br:10183/248394Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-09-02T07:59:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
title |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
spellingShingle |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? Sehn, Ana Paula Comportamento sedentário Obesidade Aptidão cardiorrespiratória Crianças Adolescentes Polimorfismo Síndrome metabólica Screen time Cardiorespiratory ftness FTO polymorphism Metabolic syndrome Childhood Young |
title_short |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
title_full |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
title_fullStr |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
title_full_unstemmed |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
title_sort |
What is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score? |
author |
Sehn, Ana Paula |
author_facet |
Sehn, Ana Paula Brand, Caroline Silveira, João Francisco de Castro Andersen, Lars Bo Gaya, Anelise Reis Todendi, Pâmela Ferreira Valim, Andréia Rosane de Moura Reuter, Cézane Priscila |
author_role |
author |
author2 |
Brand, Caroline Silveira, João Francisco de Castro Andersen, Lars Bo Gaya, Anelise Reis Todendi, Pâmela Ferreira Valim, Andréia Rosane de Moura Reuter, Cézane Priscila |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Sehn, Ana Paula Brand, Caroline Silveira, João Francisco de Castro Andersen, Lars Bo Gaya, Anelise Reis Todendi, Pâmela Ferreira Valim, Andréia Rosane de Moura Reuter, Cézane Priscila |
dc.subject.por.fl_str_mv |
Comportamento sedentário Obesidade Aptidão cardiorrespiratória Crianças Adolescentes Polimorfismo Síndrome metabólica |
topic |
Comportamento sedentário Obesidade Aptidão cardiorrespiratória Crianças Adolescentes Polimorfismo Síndrome metabólica Screen time Cardiorespiratory ftness FTO polymorphism Metabolic syndrome Childhood Young |
dc.subject.eng.fl_str_mv |
Screen time Cardiorespiratory ftness FTO polymorphism Metabolic syndrome Childhood Young |
description |
Background: Genetic factors along with inadequate lifestyle habits are associated with the development of cardiometabolic alterations. Thus, the present study aimed to examine the role of sedentary behavior on the relationship between rs9939609 polymorphism (fat mass and obesity-associated gene-FTO) and cardiometabolic risk score according to cardiorespiratory ftness (CRF) levels in children and adolescents. Methods: A cross-sectional study with 1215 children and adolescents (692 girls), aged between 6 and 17 years. Screen time as a marker of sedentary behavior was evaluated through a self-reported questionnaire and CRF was estimated using the 6-min walking and running test. The genotyping of the FTO rs9939609 polymorphism was performed using a real-time polymerase chain reaction. Clustered cardiometabolic risk score (cMetS) was calculated by summing z-scores of total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, glucose, systolic blood pressure, and waist circumference, and dividing it by fve. Moderation analyses were tested using multiple linear regression models. Results: The coefcient of the interaction term of FTO (rs9939609) and screen time indicated that screen time was a signifcant moderator on the relationship between FTO rs9939609 polymorphism and cMetS (p=0.047) in children and adolescents classifed with low CRF (β=0.001; 95% CI=0.001; 0.002). It was observed a signifcant association between genotype risk (AA) of FTO polymorphism and cMetS, in participants that spent more than 378 min a day in front of screen-based devices (β=0.203; 95% CI=0.000; 0.405). No interaction term was found for those with high CRF. Conclusions: High sedentary behavior seems to infuence the relationship between genetic predisposition to obesity and cardiometabolic risk factors in children and adolescents with low CRF. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-09-01T05:00:14Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/248394 |
dc.identifier.issn.pt_BR.fl_str_mv |
1471-2261 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001145960 |
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1471-2261 001145960 |
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http://hdl.handle.net/10183/248394 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
BMC Cardiovascular Disorders. London. v. 22 (2022), 92, p. 1-9. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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