Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/183990 |
Resumo: | Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology suggest the involvement of cancer stem cells (CSCs) in tumor progression and chemoresistance and radioresistance phenotype. We found that histone acetyltransferase inhibitors (HDACi) were capable of disrupting CSCs in MEC. Furthermore, administration of HDACi prior to Cisplatin (two-hit approach) disrupts CSCs and sensitizes tumor cells to Cisplatin. Our findings corroborate to emerging evidence that CSCs play a key role in tumor resistance to chemotherapy, and highlights a pharmacological two-hit approach that disrupts tumor resistance to conventional therapy. |
id |
UFRGS-2_f60b8df715d9326a951822d58716a00d |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/183990 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Guimarães, Douglas M.Almeida, Luciana OliveiraMartins, Manoela DominguesWarner, KristySantos-Silva, Alan RogerVargas, Pablo AgustinNunes, Fábio DaumasSquarize, Cristiane HelenaNor, Jacques EduardoCastilho, Rogerio Moraes2018-10-26T02:43:25Z20161949-2553http://hdl.handle.net/10183/183990001059508Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology suggest the involvement of cancer stem cells (CSCs) in tumor progression and chemoresistance and radioresistance phenotype. We found that histone acetyltransferase inhibitors (HDACi) were capable of disrupting CSCs in MEC. Furthermore, administration of HDACi prior to Cisplatin (two-hit approach) disrupts CSCs and sensitizes tumor cells to Cisplatin. Our findings corroborate to emerging evidence that CSCs play a key role in tumor resistance to chemotherapy, and highlights a pharmacological two-hit approach that disrupts tumor resistance to conventional therapy.application/pdfengOncotarget. Albany. Vol. 7, no. 27 (July 2016), p. 42447-42460Patologia bucalCarcinoma bucalCélulas-tronco neoplásicasSensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cellsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001059508.pdfTexto completo (inglês)application/pdf6047204http://www.lume.ufrgs.br/bitstream/10183/183990/1/001059508.pdff3c1eceed4e87325e850b00648b66040MD51TEXT001059508.pdf.txt001059508.pdf.txtExtracted Texttext/plain53658http://www.lume.ufrgs.br/bitstream/10183/183990/2/001059508.pdf.txta3994ce7cfcc93bd293a6076f203e496MD52THUMBNAIL001059508.pdf.jpg001059508.pdf.jpgGenerated Thumbnailimage/jpeg2269http://www.lume.ufrgs.br/bitstream/10183/183990/3/001059508.pdf.jpg1f386c8aea9d13dd8c1de85f6fea7492MD5310183/1839902018-10-27 03:12:32.192091oai:www.lume.ufrgs.br:10183/183990Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-27T06:12:32Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
title |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
spellingShingle |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells Guimarães, Douglas M. Patologia bucal Carcinoma bucal Células-tronco neoplásicas |
title_short |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
title_full |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
title_fullStr |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
title_full_unstemmed |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
title_sort |
Sensitizing mucoepidermoid carcinomas to chemotherapy by targeted disruption of cancer stem cells |
author |
Guimarães, Douglas M. |
author_facet |
Guimarães, Douglas M. Almeida, Luciana Oliveira Martins, Manoela Domingues Warner, Kristy Santos-Silva, Alan Roger Vargas, Pablo Agustin Nunes, Fábio Daumas Squarize, Cristiane Helena Nor, Jacques Eduardo Castilho, Rogerio Moraes |
author_role |
author |
author2 |
Almeida, Luciana Oliveira Martins, Manoela Domingues Warner, Kristy Santos-Silva, Alan Roger Vargas, Pablo Agustin Nunes, Fábio Daumas Squarize, Cristiane Helena Nor, Jacques Eduardo Castilho, Rogerio Moraes |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guimarães, Douglas M. Almeida, Luciana Oliveira Martins, Manoela Domingues Warner, Kristy Santos-Silva, Alan Roger Vargas, Pablo Agustin Nunes, Fábio Daumas Squarize, Cristiane Helena Nor, Jacques Eduardo Castilho, Rogerio Moraes |
dc.subject.por.fl_str_mv |
Patologia bucal Carcinoma bucal Células-tronco neoplásicas |
topic |
Patologia bucal Carcinoma bucal Células-tronco neoplásicas |
description |
Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology suggest the involvement of cancer stem cells (CSCs) in tumor progression and chemoresistance and radioresistance phenotype. We found that histone acetyltransferase inhibitors (HDACi) were capable of disrupting CSCs in MEC. Furthermore, administration of HDACi prior to Cisplatin (two-hit approach) disrupts CSCs and sensitizes tumor cells to Cisplatin. Our findings corroborate to emerging evidence that CSCs play a key role in tumor resistance to chemotherapy, and highlights a pharmacological two-hit approach that disrupts tumor resistance to conventional therapy. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-10-26T02:43:25Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/183990 |
dc.identifier.issn.pt_BR.fl_str_mv |
1949-2553 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001059508 |
identifier_str_mv |
1949-2553 001059508 |
url |
http://hdl.handle.net/10183/183990 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Oncotarget. Albany. Vol. 7, no. 27 (July 2016), p. 42447-42460 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/183990/1/001059508.pdf http://www.lume.ufrgs.br/bitstream/10183/183990/2/001059508.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/183990/3/001059508.pdf.jpg |
bitstream.checksum.fl_str_mv |
f3c1eceed4e87325e850b00648b66040 a3994ce7cfcc93bd293a6076f203e496 1f386c8aea9d13dd8c1de85f6fea7492 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224954278051840 |