Waterborne aripiprazole blunts the stress response in zebrafish

• Autor(a) principal: Barcellos, Heloisa Helena de Alcantara
• Data de Publicação: 2016
• Outros Autores: Kalichak, Fabiana, Rosa, João Gabriel Santos, Oliveira, Thiago Acosta, Koakoski, Gessi, Idalencio, Renan, Abreu, Murilo Sander de, Giacomini, Ana Cristina Vendrametto Varrone, Fagundes, Michele, Variani, Cristiane, Rossini, Mainara, Piato, Angelo Luis Stapassoli, Barcellos, Leonardo Jose Gil
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/225520
• topic: Aripiprazol; Águas residuais; Peixe-zebra; Environmental impact; Stress and resilience

Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.