Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies

Detalhes bibliográficos
Autor(a) principal: Almeida, Juliana S.
Data de Publicação: 2010
Outros Autores: Lima, Fernanda, Ros, Simoní da, Bulhões, Luis O.S., Carvalho, Leandro Machado de, Beck, Ruy Carlos Ruver
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/109964
Resumo: The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.
id UFRGS-2_f79a70b5d10a312b46fc590036165468
oai_identifier_str oai:www.lume.ufrgs.br:10183/109964
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Almeida, Juliana S.Lima, FernandaRos, Simoní daBulhões, Luis O.S.Carvalho, Leandro Machado deBeck, Ruy Carlos Ruver2015-02-11T02:18:08Z20101556-276xhttp://hdl.handle.net/10183/109964000777855The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.application/pdfengNanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610NanocápsulasAtividade antioxidanteRutinaAntioxidant activityNanocapsulesNanoemulsionsNanoparticlesPhotostabilityRutinNanostructured systems containing rutin: in vitro antioxidant activity and photostability studiesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000777855.pdf000777855.pdfTexto completo (inglês)application/pdf325495http://www.lume.ufrgs.br/bitstream/10183/109964/1/000777855.pdfaca5fbe5e27f812ad810afa3841028c1MD51TEXT000777855.pdf.txt000777855.pdf.txtExtracted Texttext/plain32414http://www.lume.ufrgs.br/bitstream/10183/109964/2/000777855.pdf.txt4a2e04e8b7f809a841f2c03a56df151eMD52THUMBNAIL000777855.pdf.jpg000777855.pdf.jpgGenerated Thumbnailimage/jpeg1820http://www.lume.ufrgs.br/bitstream/10183/109964/3/000777855.pdf.jpg512ff8db513f4125d8a7e0fcefecca9eMD5310183/1099642019-12-28 05:01:01.504693oai:www.lume.ufrgs.br:10183/109964Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2019-12-28T07:01:01Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
title Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
spellingShingle Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
Almeida, Juliana S.
Nanocápsulas
Atividade antioxidante
Rutina
Antioxidant activity
Nanocapsules
Nanoemulsions
Nanoparticles
Photostability
Rutin
title_short Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
title_full Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
title_fullStr Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
title_full_unstemmed Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
title_sort Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
author Almeida, Juliana S.
author_facet Almeida, Juliana S.
Lima, Fernanda
Ros, Simoní da
Bulhões, Luis O.S.
Carvalho, Leandro Machado de
Beck, Ruy Carlos Ruver
author_role author
author2 Lima, Fernanda
Ros, Simoní da
Bulhões, Luis O.S.
Carvalho, Leandro Machado de
Beck, Ruy Carlos Ruver
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Juliana S.
Lima, Fernanda
Ros, Simoní da
Bulhões, Luis O.S.
Carvalho, Leandro Machado de
Beck, Ruy Carlos Ruver
dc.subject.por.fl_str_mv Nanocápsulas
Atividade antioxidante
Rutina
topic Nanocápsulas
Atividade antioxidante
Rutina
Antioxidant activity
Nanocapsules
Nanoemulsions
Nanoparticles
Photostability
Rutin
dc.subject.eng.fl_str_mv Antioxidant activity
Nanocapsules
Nanoemulsions
Nanoparticles
Photostability
Rutin
description The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2015-02-11T02:18:08Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/109964
dc.identifier.issn.pt_BR.fl_str_mv 1556-276x
dc.identifier.nrb.pt_BR.fl_str_mv 000777855
identifier_str_mv 1556-276x
000777855
url http://hdl.handle.net/10183/109964
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Nanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/109964/1/000777855.pdf
http://www.lume.ufrgs.br/bitstream/10183/109964/2/000777855.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/109964/3/000777855.pdf.jpg
bitstream.checksum.fl_str_mv aca5fbe5e27f812ad810afa3841028c1
4a2e04e8b7f809a841f2c03a56df151e
512ff8db513f4125d8a7e0fcefecca9e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv lume@ufrgs.br
_version_ 1824427220169392128