Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/109964 |
Resumo: | The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines. |
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Almeida, Juliana S.Lima, FernandaRos, Simoní daBulhões, Luis O.S.Carvalho, Leandro Machado deBeck, Ruy Carlos Ruver2015-02-11T02:18:08Z20101556-276xhttp://hdl.handle.net/10183/109964000777855The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines.application/pdfengNanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610NanocápsulasAtividade antioxidanteRutinaAntioxidant activityNanocapsulesNanoemulsionsNanoparticlesPhotostabilityRutinNanostructured systems containing rutin: in vitro antioxidant activity and photostability studiesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000777855.pdf000777855.pdfTexto completo (inglês)application/pdf325495http://www.lume.ufrgs.br/bitstream/10183/109964/1/000777855.pdfaca5fbe5e27f812ad810afa3841028c1MD51TEXT000777855.pdf.txt000777855.pdf.txtExtracted Texttext/plain32414http://www.lume.ufrgs.br/bitstream/10183/109964/2/000777855.pdf.txt4a2e04e8b7f809a841f2c03a56df151eMD52THUMBNAIL000777855.pdf.jpg000777855.pdf.jpgGenerated Thumbnailimage/jpeg1820http://www.lume.ufrgs.br/bitstream/10183/109964/3/000777855.pdf.jpg512ff8db513f4125d8a7e0fcefecca9eMD5310183/1099642019-12-28 05:01:01.504693oai:www.lume.ufrgs.br:10183/109964Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2019-12-28T07:01:01Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
title |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
spellingShingle |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies Almeida, Juliana S. Nanocápsulas Atividade antioxidante Rutina Antioxidant activity Nanocapsules Nanoemulsions Nanoparticles Photostability Rutin |
title_short |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
title_full |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
title_fullStr |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
title_full_unstemmed |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
title_sort |
Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies |
author |
Almeida, Juliana S. |
author_facet |
Almeida, Juliana S. Lima, Fernanda Ros, Simoní da Bulhões, Luis O.S. Carvalho, Leandro Machado de Beck, Ruy Carlos Ruver |
author_role |
author |
author2 |
Lima, Fernanda Ros, Simoní da Bulhões, Luis O.S. Carvalho, Leandro Machado de Beck, Ruy Carlos Ruver |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Juliana S. Lima, Fernanda Ros, Simoní da Bulhões, Luis O.S. Carvalho, Leandro Machado de Beck, Ruy Carlos Ruver |
dc.subject.por.fl_str_mv |
Nanocápsulas Atividade antioxidante Rutina |
topic |
Nanocápsulas Atividade antioxidante Rutina Antioxidant activity Nanocapsules Nanoemulsions Nanoparticles Photostability Rutin |
dc.subject.eng.fl_str_mv |
Antioxidant activity Nanocapsules Nanoemulsions Nanoparticles Photostability Rutin |
description |
The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 ± 2.06 and 124.17 ± 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 ± 0.6) 10-3 and (5.1 ± 0.4) 10-3 for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 ± 3.7) 10-3 min-1] and exposed solution [(40.1 ± 1.7) 10-3 min-1] as well as compared to exposed nanostructured dispersions [(19.5 ± 0.5) 10-3 and (26.6 ± 2.6) 10-3, for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutinloaded nanostructures represent alternatives to the development of innovative nanomedicines. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2015-02-11T02:18:08Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/109964 |
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1556-276x |
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000777855 |
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http://hdl.handle.net/10183/109964 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Nanoscale research letters. New York. Vol. 5, n. 10 (July 2010), p. 1603-1610 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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