The use of tau PET to stage Alzheimer disease according to the braak staging framework
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/275403 |
Resumo: | Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak and Braak proposed a histopathologic staging system for AD. Braak staging provides a compelling framework for staging and monitoring of NFT progression in vivo using PET imaging. Because AD staging remains based on clinical features, there is an unmet need to translate neuropathologic staging to a biologic clinical staging system. Such a biomarker staging system might play a role in staging preclinical AD or in improving recruitment strategies for clinical trials. Here, we review the literature regarding AD staging with the Braak framework using tau PET imaging, here called PET-based Braak staging. Our aim is to summarize the efforts of implementing Braak staging using PET and assess correspondence with the Braak histopathologic descriptions and with AD biomarkers. Methods: We conducted a systematic literature search in May 2022 on PubMed and Scopus combining the terms “Alzheimer” AND “Braak” AND (“positron emission tomography” OR “PET”). Results: The database search returned 262 results, and after assessment for eligibility, 21 studies were selected. Overall, most studies indicate that PET-based Braak staging may be an efficient method to stage AD since it presents an adequate ability to discriminate between phases of the AD continuum and correlates with clinical, fluid, and imaging biomarkers of AD. However, the translation of the original Braak descriptions to tau PET was done taking into account the limitations of this imaging technique. This led to important interstudy variability in the anatomic definitions of Braak stage regions of interest. Conclusion: Refinements in this staging system are necessary to incorporate atypical variants and Braak-nonconformant cases. Further studies are needed to understand the possible applications of PET-based Braak staging to clinical practice and research. Furthermore, there is a need for standardization in the topographic definitions of Braak stage regions of interest to guarantee reproducibility and methodologic homogeneity across studies. |
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Macedo, Arthur C.Tissot, CecileTherriault, JosephServaes, StijnWang, Yi Ting TinaFernandez-Arias, JaimeRahmouni, NesrineLussier, Firoza Z.Vermeiren, Marie R.Bezgin, Gleb Y.Vitali, PaoloNg, Kok PinZimmer, Eduardo RigonGuiot, Marie ChristinePascoal, Tharick AliGauthier, Serge G.Rosa Neto, Pedro2024-05-23T06:42:38Z20230161-5505http://hdl.handle.net/10183/275403001187056Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak and Braak proposed a histopathologic staging system for AD. Braak staging provides a compelling framework for staging and monitoring of NFT progression in vivo using PET imaging. Because AD staging remains based on clinical features, there is an unmet need to translate neuropathologic staging to a biologic clinical staging system. Such a biomarker staging system might play a role in staging preclinical AD or in improving recruitment strategies for clinical trials. Here, we review the literature regarding AD staging with the Braak framework using tau PET imaging, here called PET-based Braak staging. Our aim is to summarize the efforts of implementing Braak staging using PET and assess correspondence with the Braak histopathologic descriptions and with AD biomarkers. Methods: We conducted a systematic literature search in May 2022 on PubMed and Scopus combining the terms “Alzheimer” AND “Braak” AND (“positron emission tomography” OR “PET”). Results: The database search returned 262 results, and after assessment for eligibility, 21 studies were selected. Overall, most studies indicate that PET-based Braak staging may be an efficient method to stage AD since it presents an adequate ability to discriminate between phases of the AD continuum and correlates with clinical, fluid, and imaging biomarkers of AD. However, the translation of the original Braak descriptions to tau PET was done taking into account the limitations of this imaging technique. This led to important interstudy variability in the anatomic definitions of Braak stage regions of interest. Conclusion: Refinements in this staging system are necessary to incorporate atypical variants and Braak-nonconformant cases. Further studies are needed to understand the possible applications of PET-based Braak staging to clinical practice and research. Furthermore, there is a need for standardization in the topographic definitions of Braak stage regions of interest to guarantee reproducibility and methodologic homogeneity across studies.application/pdfengJournal of nuclear medicine. Reston, VA. Vol. 64, no. 8 (Aug. 2023), p. 1171-1178Doenças neurodegenerativasDoença de AlzheimerProteínas tauEmaranhados neurofibrilaresDisfunção cognitivaTomografia por emissão de pósitronsAlzheimer diseaseBraak stagingPETNeurofibrillary tanglesCognitive impairmentThe use of tau PET to stage Alzheimer disease according to the braak staging frameworkEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001187056.pdf.txt001187056.pdf.txtExtracted Texttext/plain45874http://www.lume.ufrgs.br/bitstream/10183/275403/2/001187056.pdf.txt9725464521a0338f690b6dac4d8a4d8dMD52ORIGINAL001187056.pdfTexto completo (inglês)application/pdf1140328http://www.lume.ufrgs.br/bitstream/10183/275403/1/001187056.pdfcb40439673f42b9146dce6b711c17af9MD5110183/2754032024-05-24 06:41:52.324932oai:www.lume.ufrgs.br:10183/275403Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-05-24T09:41:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
title |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
spellingShingle |
The use of tau PET to stage Alzheimer disease according to the braak staging framework Macedo, Arthur C. Doenças neurodegenerativas Doença de Alzheimer Proteínas tau Emaranhados neurofibrilares Disfunção cognitiva Tomografia por emissão de pósitrons Alzheimer disease Braak staging PET Neurofibrillary tangles Cognitive impairment |
title_short |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
title_full |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
title_fullStr |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
title_full_unstemmed |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
title_sort |
The use of tau PET to stage Alzheimer disease according to the braak staging framework |
author |
Macedo, Arthur C. |
author_facet |
Macedo, Arthur C. Tissot, Cecile Therriault, Joseph Servaes, Stijn Wang, Yi Ting Tina Fernandez-Arias, Jaime Rahmouni, Nesrine Lussier, Firoza Z. Vermeiren, Marie R. Bezgin, Gleb Y. Vitali, Paolo Ng, Kok Pin Zimmer, Eduardo Rigon Guiot, Marie Christine Pascoal, Tharick Ali Gauthier, Serge G. Rosa Neto, Pedro |
author_role |
author |
author2 |
Tissot, Cecile Therriault, Joseph Servaes, Stijn Wang, Yi Ting Tina Fernandez-Arias, Jaime Rahmouni, Nesrine Lussier, Firoza Z. Vermeiren, Marie R. Bezgin, Gleb Y. Vitali, Paolo Ng, Kok Pin Zimmer, Eduardo Rigon Guiot, Marie Christine Pascoal, Tharick Ali Gauthier, Serge G. Rosa Neto, Pedro |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Macedo, Arthur C. Tissot, Cecile Therriault, Joseph Servaes, Stijn Wang, Yi Ting Tina Fernandez-Arias, Jaime Rahmouni, Nesrine Lussier, Firoza Z. Vermeiren, Marie R. Bezgin, Gleb Y. Vitali, Paolo Ng, Kok Pin Zimmer, Eduardo Rigon Guiot, Marie Christine Pascoal, Tharick Ali Gauthier, Serge G. Rosa Neto, Pedro |
dc.subject.por.fl_str_mv |
Doenças neurodegenerativas Doença de Alzheimer Proteínas tau Emaranhados neurofibrilares Disfunção cognitiva Tomografia por emissão de pósitrons |
topic |
Doenças neurodegenerativas Doença de Alzheimer Proteínas tau Emaranhados neurofibrilares Disfunção cognitiva Tomografia por emissão de pósitrons Alzheimer disease Braak staging PET Neurofibrillary tangles Cognitive impairment |
dc.subject.eng.fl_str_mv |
Alzheimer disease Braak staging PET Neurofibrillary tangles Cognitive impairment |
description |
Amyloid-β plaques and neurofibrillary tangles (NFTs) are the 2 histopathologic hallmarks of Alzheimer disease (AD). On the basis of the pattern of NFT distribution in the brain, Braak and Braak proposed a histopathologic staging system for AD. Braak staging provides a compelling framework for staging and monitoring of NFT progression in vivo using PET imaging. Because AD staging remains based on clinical features, there is an unmet need to translate neuropathologic staging to a biologic clinical staging system. Such a biomarker staging system might play a role in staging preclinical AD or in improving recruitment strategies for clinical trials. Here, we review the literature regarding AD staging with the Braak framework using tau PET imaging, here called PET-based Braak staging. Our aim is to summarize the efforts of implementing Braak staging using PET and assess correspondence with the Braak histopathologic descriptions and with AD biomarkers. Methods: We conducted a systematic literature search in May 2022 on PubMed and Scopus combining the terms “Alzheimer” AND “Braak” AND (“positron emission tomography” OR “PET”). Results: The database search returned 262 results, and after assessment for eligibility, 21 studies were selected. Overall, most studies indicate that PET-based Braak staging may be an efficient method to stage AD since it presents an adequate ability to discriminate between phases of the AD continuum and correlates with clinical, fluid, and imaging biomarkers of AD. However, the translation of the original Braak descriptions to tau PET was done taking into account the limitations of this imaging technique. This led to important interstudy variability in the anatomic definitions of Braak stage regions of interest. Conclusion: Refinements in this staging system are necessary to incorporate atypical variants and Braak-nonconformant cases. Further studies are needed to understand the possible applications of PET-based Braak staging to clinical practice and research. Furthermore, there is a need for standardization in the topographic definitions of Braak stage regions of interest to guarantee reproducibility and methodologic homogeneity across studies. |
publishDate |
2023 |
dc.date.issued.fl_str_mv |
2023 |
dc.date.accessioned.fl_str_mv |
2024-05-23T06:42:38Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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http://hdl.handle.net/10183/275403 |
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0161-5505 |
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001187056 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of nuclear medicine. Reston, VA. Vol. 64, no. 8 (Aug. 2023), p. 1171-1178 |
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