Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity

Detalhes bibliográficos
Autor(a) principal: Salame,Marcelo
Data de Publicação: 2015
Outros Autores: Costa,Karen Koff da, Zottele,Lucas Venturini, Muradás,Raquel Rodrigues, Tierno,Sibelle de Almeida, Schettinger,Maria Rosa Chitolina, Premaor,Melissa, Beck,Maristela de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Geriatria e Gerontologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-98232015000200285
Resumo: INTRODUCTION: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it. OBJECTIVE: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. METHODS: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht2), cutoffs 5.5 kg/m2, 2SD, 10th percentile, and 20th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20th percentile of elderly. RESULTS: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht2 cutoff 10th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. CONCLUSION: Of these criteria, aLM/ht2 cutoff 10th percentile had stronger correlation with muscle strength.
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spelling Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacitySarcopeniaPostmenopauseMuscle StrengthCalibrationDiscrimination INTRODUCTION: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it. OBJECTIVE: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. METHODS: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht2), cutoffs 5.5 kg/m2, 2SD, 10th percentile, and 20th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20th percentile of elderly. RESULTS: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht2 cutoff 10th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. CONCLUSION: Of these criteria, aLM/ht2 cutoff 10th percentile had stronger correlation with muscle strength. Universidade do Estado do Rio Janeiro2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-98232015000200285Revista Brasileira de Geriatria e Gerontologia v.18 n.2 2015reponame:Revista Brasileira de Geriatria e Gerontologiainstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UFRJ10.1590/1809-9823.2015.14025info:eu-repo/semantics/openAccessSalame,MarceloCosta,Karen Koff daZottele,Lucas VenturiniMuradás,Raquel RodriguesTierno,Sibelle de AlmeidaSchettinger,Maria Rosa ChitolinaPremaor,MelissaBeck,Maristela de Oliveiraeng2015-07-28T00:00:00Zoai:scielo:S1809-98232015000200285Revistahttp://revista.unati.uerj.br/scielo.php?script=sci_serial&pid=1809-9823&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||revistabgg@gmail.com1981-22561809-9823opendoar:2015-07-28T00:00Revista Brasileira de Geriatria e Gerontologia - Universidade do Estado do Rio de Janeiro (UERJ)false
dc.title.none.fl_str_mv Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
title Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
spellingShingle Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
Salame,Marcelo
Sarcopenia
Postmenopause
Muscle Strength
Calibration
Discrimination
title_short Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
title_full Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
title_fullStr Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
title_full_unstemmed Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
title_sort Sarcopenia: evaluation of different diagnostic criteria and its association with muscle strength and functional capacity
author Salame,Marcelo
author_facet Salame,Marcelo
Costa,Karen Koff da
Zottele,Lucas Venturini
Muradás,Raquel Rodrigues
Tierno,Sibelle de Almeida
Schettinger,Maria Rosa Chitolina
Premaor,Melissa
Beck,Maristela de Oliveira
author_role author
author2 Costa,Karen Koff da
Zottele,Lucas Venturini
Muradás,Raquel Rodrigues
Tierno,Sibelle de Almeida
Schettinger,Maria Rosa Chitolina
Premaor,Melissa
Beck,Maristela de Oliveira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salame,Marcelo
Costa,Karen Koff da
Zottele,Lucas Venturini
Muradás,Raquel Rodrigues
Tierno,Sibelle de Almeida
Schettinger,Maria Rosa Chitolina
Premaor,Melissa
Beck,Maristela de Oliveira
dc.subject.por.fl_str_mv Sarcopenia
Postmenopause
Muscle Strength
Calibration
Discrimination
topic Sarcopenia
Postmenopause
Muscle Strength
Calibration
Discrimination
description INTRODUCTION: Sarcopenia has been associated with increased morbidity and mortality in older people. However, there is still no consensus about the best diagnostic criteria for it. OBJECTIVE: This study aimed to evaluate different diagnostic criteria of sarcopenia and their relationship with muscle strength and functional capacity. METHODS: A cross-sectional study was carried out in Santa Maria-RS, Brazil. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Physical performance was evaluated by the Timed-get-up-and-go test (TGUG). Muscle strength was measured with a handgrip dynamometer. The proposed criteria of sarcopenia were evaluated as follows: A) appendicular lean mass index (aLM/ht2), cutoffs 5.5 kg/m2, 2SD, 10th percentile, and 20th percentile of young reference; B) a linear regression model was used to adjust appendicular lean mass (aLM) for both height and fat mass, cutoff 20th percentile of elderly. RESULTS: In total, 104 women agreed to participate in the research, 39 young (20 to 40 years) and 65 elderly (over 60 years). The prevalence of sarcopenia varied from 0% to 17.2% according to the diagnostic criteria. Regarding muscle strength, the aLM/ht2 cutoff 10th percentile was the criterion with greater area under the ROC curve. However, there were no criteria with an area under the ROC curve greater than 0.5 when TGUG was the outcome. The reclassification showed that the criterion B reclassified 66.7% with normal grip strength as sarcopenic. CONCLUSION: Of these criteria, aLM/ht2 cutoff 10th percentile had stronger correlation with muscle strength.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1809-98232015000200285
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1809-9823.2015.14025
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade do Estado do Rio Janeiro
publisher.none.fl_str_mv Universidade do Estado do Rio Janeiro
dc.source.none.fl_str_mv Revista Brasileira de Geriatria e Gerontologia v.18 n.2 2015
reponame:Revista Brasileira de Geriatria e Gerontologia
instname:Universidade do Estado do Rio de Janeiro (UERJ)
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instname_str Universidade do Estado do Rio de Janeiro (UERJ)
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institution UFRJ
reponame_str Revista Brasileira de Geriatria e Gerontologia
collection Revista Brasileira de Geriatria e Gerontologia
repository.name.fl_str_mv Revista Brasileira de Geriatria e Gerontologia - Universidade do Estado do Rio de Janeiro (UERJ)
repository.mail.fl_str_mv ||revistabgg@gmail.com
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