Cerebral perfusion and automated individual analysis using SPECT among an obsessive-compulsive population

• Autor(a) principal: Rocha,Euclides Timóteo da
• Data de Publicação: 2011
• Outros Autores: Buchpiguel,Carlos Alberto, Miguel,Euripedes Constantino, Peres,Stela Verzinhase, Busatto Filho,Geraldo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Jornal Brasileiro de Psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852011000100001
• topic: Brain SPECT; SPM; OCD; individual analysis

OBJECTIVE: To make individual assessments using automated quantification methodology in order to screen for perfusion abnormalities in cerebral SPECT examinations among a sample of subjects with OCD. METHODS: Statistical parametric mapping (SPM) was used to compare 26 brain SPECT images from patients with OCD individually with an image bank of 32 normal subjects, using the statistical threshold of p < 0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). The maps were analyzed, and regions presenting voxels that remained above this threshold were sought. RESULTS: Six patients from a sample of 26 OCD images showed abnormalities at cluster or voxel level, considering the criteria described above, which represented 23.07%. However, seven images from the normal group of 32 were also indicated as cases of perfusional abnormality, representing 21.8% of the sample. CONCLUSION: The automated quantification method was not considered to be a useful tool for clinical practice, for analyses complementary to visual inspection.