Depressive symptoms and neurotrophin levels in ostomy patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852018000300166 |
Resumo: | ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients. |
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Depressive symptoms and neurotrophin levels in ostomy patientsOstomyBDNFNGFNT-3depressionABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro2018-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852018000300166Jornal Brasileiro de Psiquiatria v.67 n.3 2018reponame:Jornal Brasileiro de Psiquiatria (Online)instname:Universidade Federal do Rio de Janeiro (UFRJ)instacron:UFRJ10.1590/0047-2085000000203info:eu-repo/semantics/openAccessBavaresco,Daniela VicenteSchwalm,Mágada TessmannJornada,Luciano KurtzQuadros,Luiz Felipe AndradeSimon,BrunaCeretta,Luciane BisogninZimmermann,Karina Cardoso GulbisRosa,Maria Inês daValvassori,Samira Silvaeng2018-09-19T00:00:00Zoai:scielo:S0047-20852018000300166Revistahttp://portalrev.enfermagem.bvs.br/index.php?issn=0047-2085&lang=ptONGhttps://old.scielo.br/oai/scielo-oai.php||editora@ipub.ufrj.br1982-02080047-2085opendoar:2018-09-19T00:00Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ)false |
dc.title.none.fl_str_mv |
Depressive symptoms and neurotrophin levels in ostomy patients |
title |
Depressive symptoms and neurotrophin levels in ostomy patients |
spellingShingle |
Depressive symptoms and neurotrophin levels in ostomy patients Bavaresco,Daniela Vicente Ostomy BDNF NGF NT-3 depression |
title_short |
Depressive symptoms and neurotrophin levels in ostomy patients |
title_full |
Depressive symptoms and neurotrophin levels in ostomy patients |
title_fullStr |
Depressive symptoms and neurotrophin levels in ostomy patients |
title_full_unstemmed |
Depressive symptoms and neurotrophin levels in ostomy patients |
title_sort |
Depressive symptoms and neurotrophin levels in ostomy patients |
author |
Bavaresco,Daniela Vicente |
author_facet |
Bavaresco,Daniela Vicente Schwalm,Mágada Tessmann Jornada,Luciano Kurtz Quadros,Luiz Felipe Andrade Simon,Bruna Ceretta,Luciane Bisognin Zimmermann,Karina Cardoso Gulbis Rosa,Maria Inês da Valvassori,Samira Silva |
author_role |
author |
author2 |
Schwalm,Mágada Tessmann Jornada,Luciano Kurtz Quadros,Luiz Felipe Andrade Simon,Bruna Ceretta,Luciane Bisognin Zimmermann,Karina Cardoso Gulbis Rosa,Maria Inês da Valvassori,Samira Silva |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bavaresco,Daniela Vicente Schwalm,Mágada Tessmann Jornada,Luciano Kurtz Quadros,Luiz Felipe Andrade Simon,Bruna Ceretta,Luciane Bisognin Zimmermann,Karina Cardoso Gulbis Rosa,Maria Inês da Valvassori,Samira Silva |
dc.subject.por.fl_str_mv |
Ostomy BDNF NGF NT-3 depression |
topic |
Ostomy BDNF NGF NT-3 depression |
description |
ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852018000300166 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852018000300166 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0047-2085000000203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
publisher.none.fl_str_mv |
Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Psiquiatria v.67 n.3 2018 reponame:Jornal Brasileiro de Psiquiatria (Online) instname:Universidade Federal do Rio de Janeiro (UFRJ) instacron:UFRJ |
instname_str |
Universidade Federal do Rio de Janeiro (UFRJ) |
instacron_str |
UFRJ |
institution |
UFRJ |
reponame_str |
Jornal Brasileiro de Psiquiatria (Online) |
collection |
Jornal Brasileiro de Psiquiatria (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Psiquiatria (Online) - Universidade Federal do Rio de Janeiro (UFRJ) |
repository.mail.fl_str_mv |
||editora@ipub.ufrj.br |
_version_ |
1750128247046144000 |