Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/19395 |
Resumo: | Autism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and repetitive behaviors with restricted interests. A number of studies have reported that sensory perception abnormalities are common in autistic individuals and might contribute to the complex behavioral symptoms of the disorder. In this context, hearing incongruence is particularly prevalent. Considering that some of this abnormal processing might stem from the unbalance of inhibitory and excitatory drives in brain circuitries, we used an animal model of autism induced by valproic acid (VPA) during pregnancy in order to investigate the tonotopic organization of the primary auditory cortex (AI) and its local inhibitory circuitry. Our results show that VPA rats have distorted primary auditory maps with over-representation of high frequencies, broadly tuned receptive fields and higher sound intensity thresholds as compared to controls. However, we did not detect differences in the number of parvalbumin-positive interneurons in AI of VPA and control rats. Altogether our findings show that neurophysiological impairments of hearing perception in this autism model occur independently of alterations in the number of parvalbumin-expressing interneurons. These data support the notion that fine circuit alterations, rather than gross cellular modification, could lead to neurophysiological changes in the autistic brain |
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Anomal, Renata FigueiredoVillers-Sidani, Etienne deBrandão, Juliana AlvesDiniz, RebeccaCosta, Marcos RomualdoRomcy-Pereira, Rodrigo Neves2015-11-27T20:53:42Z2015-11-27T20:53:42Z2015Anomal RF, de Villers-Sidani E, Brandão JA, Diniz R, Costa MR and Romcy-Pereira RN (2015) Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism. Front. Syst. Neurosci. 9:158. doi: 10.3389/fnsys.2015.00158https://repositorio.ufrn.br/jspui/handle/123456789/19395engUniversidade Federal do Rio Grande do NorteUFRNBrasilanimal model of mental disordersautism spectrum disorders (ASD)auditory perceptioninhibitory neurons,cortical mappingImpaired Processing in the Primary Auditory Cortex of an Animal Model of Autisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAutism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and repetitive behaviors with restricted interests. A number of studies have reported that sensory perception abnormalities are common in autistic individuals and might contribute to the complex behavioral symptoms of the disorder. In this context, hearing incongruence is particularly prevalent. Considering that some of this abnormal processing might stem from the unbalance of inhibitory and excitatory drives in brain circuitries, we used an animal model of autism induced by valproic acid (VPA) during pregnancy in order to investigate the tonotopic organization of the primary auditory cortex (AI) and its local inhibitory circuitry. Our results show that VPA rats have distorted primary auditory maps with over-representation of high frequencies, broadly tuned receptive fields and higher sound intensity thresholds as compared to controls. However, we did not detect differences in the number of parvalbumin-positive interneurons in AI of VPA and control rats. Altogether our findings show that neurophysiological impairments of hearing perception in this autism model occur independently of alterations in the number of parvalbumin-expressing interneurons. These data support the notion that fine circuit alterations, rather than gross cellular modification, could lead to neurophysiological changes in the autistic braininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALRenataAnomal_ICE_Impaired _Processing_in_the2015.pdfRenataAnomal_ICE_Impaired _Processing_in_the2015.pdfapplication/pdf1324807https://repositorio.ufrn.br/bitstream/123456789/19395/1/RenataAnomal_ICE_Impaired%20_Processing_in_the2015.pdf9b5f1b55c9c190a42fb0c0a08307f873MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/19395/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52TEXTRenataAnomal_ICE_Impaired _Processing_in_the2015.pdf.txtRenataAnomal_ICE_Impaired _Processing_in_the2015.pdf.txtExtracted texttext/plain61700https://repositorio.ufrn.br/bitstream/123456789/19395/7/RenataAnomal_ICE_Impaired%20_Processing_in_the2015.pdf.txte13cfc554c5590a22822096a9fe632b1MD57THUMBNAILRenataAnomal_ICE_Impaired _Processing_in_the2015.pdf.jpgRenataAnomal_ICE_Impaired _Processing_in_the2015.pdf.jpgIM Thumbnailimage/jpeg8000https://repositorio.ufrn.br/bitstream/123456789/19395/8/RenataAnomal_ICE_Impaired%20_Processing_in_the2015.pdf.jpge67ff10fa419406156108bc2cc818636MD58123456789/193952021-07-09 19:31:55.499oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T22:31:55Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
title |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
spellingShingle |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism Anomal, Renata Figueiredo animal model of mental disorders autism spectrum disorders (ASD) auditory perception inhibitory neurons, cortical mapping |
title_short |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
title_full |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
title_fullStr |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
title_full_unstemmed |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
title_sort |
Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism |
author |
Anomal, Renata Figueiredo |
author_facet |
Anomal, Renata Figueiredo Villers-Sidani, Etienne de Brandão, Juliana Alves Diniz, Rebecca Costa, Marcos Romualdo Romcy-Pereira, Rodrigo Neves |
author_role |
author |
author2 |
Villers-Sidani, Etienne de Brandão, Juliana Alves Diniz, Rebecca Costa, Marcos Romualdo Romcy-Pereira, Rodrigo Neves |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Anomal, Renata Figueiredo Villers-Sidani, Etienne de Brandão, Juliana Alves Diniz, Rebecca Costa, Marcos Romualdo Romcy-Pereira, Rodrigo Neves |
dc.subject.por.fl_str_mv |
animal model of mental disorders autism spectrum disorders (ASD) auditory perception inhibitory neurons, cortical mapping |
topic |
animal model of mental disorders autism spectrum disorders (ASD) auditory perception inhibitory neurons, cortical mapping |
description |
Autism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and repetitive behaviors with restricted interests. A number of studies have reported that sensory perception abnormalities are common in autistic individuals and might contribute to the complex behavioral symptoms of the disorder. In this context, hearing incongruence is particularly prevalent. Considering that some of this abnormal processing might stem from the unbalance of inhibitory and excitatory drives in brain circuitries, we used an animal model of autism induced by valproic acid (VPA) during pregnancy in order to investigate the tonotopic organization of the primary auditory cortex (AI) and its local inhibitory circuitry. Our results show that VPA rats have distorted primary auditory maps with over-representation of high frequencies, broadly tuned receptive fields and higher sound intensity thresholds as compared to controls. However, we did not detect differences in the number of parvalbumin-positive interneurons in AI of VPA and control rats. Altogether our findings show that neurophysiological impairments of hearing perception in this autism model occur independently of alterations in the number of parvalbumin-expressing interneurons. These data support the notion that fine circuit alterations, rather than gross cellular modification, could lead to neurophysiological changes in the autistic brain |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-11-27T20:53:42Z |
dc.date.available.fl_str_mv |
2015-11-27T20:53:42Z |
dc.date.issued.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Anomal RF, de Villers-Sidani E, Brandão JA, Diniz R, Costa MR and Romcy-Pereira RN (2015) Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism. Front. Syst. Neurosci. 9:158. doi: 10.3389/fnsys.2015.00158 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/19395 |
identifier_str_mv |
Anomal RF, de Villers-Sidani E, Brandão JA, Diniz R, Costa MR and Romcy-Pereira RN (2015) Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism. Front. Syst. Neurosci. 9:158. doi: 10.3389/fnsys.2015.00158 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/19395 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
dc.publisher.initials.fl_str_mv |
UFRN |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
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