Charge transport in fibrous/not fibrous -helical and variant peptides
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/30964 |
Resumo: | Although differing only by the Ala→Gln substitution at the fifth or seventh position of the 3-peptide amino acid sequence Leu-Glu-Thr-Leu-Ala-Lys-Ala3, the 5Q3 variant forms fibrous assemblies more attenuated than those of the 3-peptide, while the 7Q3 variant does not form fibrils. A tight-binding transport modeling was performed to obtain their current-voltage patterns, with hopping energies of the dipeptides calculated within the density functional theory framework. Beyond the semiconductor character, we obtain that the current pattern can be used to distinguish them, suggesting that it can be useful for the development of devices as diagnostics tools for amyloidosislike diseases |
id |
UFRN_15d8cb3ca5338628299a3c090a939c29 |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/30964 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Bezerril, Leonardo MafraFulco, Umberto LainoOliveira, Jonas Ivan NobreCorso, GilbertoAlbuquerque, Eudenilson Lins deFreire, V. N.Caetano, W. S.2020-12-11T16:23:41Z2020-12-11T16:23:41Z2011-01-31BEZERRIL, L. M.; FULCO, U. L.; OLIVEIRA, J. I. N.; CORSO, G.; ALBUQUERQUE, E. L.; FREIRE, V. N.; CAETANO, E. W. S.. Charge transport in fibrous/not fibrous α3-helical and (5Q,7Q)α3 variant peptides. Applied Physics Letters, [S.L.], v. 98, n. 5, p. 053702-053702, 31 jan. 2011. Disponível em: https://aip.scitation.org/doi/10.1063/1.3551713. Acesso em: 16 out. 2020. http://dx.doi.org/10.1063/1.3551713.0003-69511077-3118https://repositorio.ufrn.br/handle/123456789/3096410.1063/1.3551713American Institute of PhysicsCharge transportFibrous/not fibrousHelicalVariant peptidesCharge transport in fibrous/not fibrous -helical and variant peptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlthough differing only by the Ala→Gln substitution at the fifth or seventh position of the 3-peptide amino acid sequence Leu-Glu-Thr-Leu-Ala-Lys-Ala3, the 5Q3 variant forms fibrous assemblies more attenuated than those of the 3-peptide, while the 7Q3 variant does not form fibrils. A tight-binding transport modeling was performed to obtain their current-voltage patterns, with hopping energies of the dipeptides calculated within the density functional theory framework. Beyond the semiconductor character, we obtain that the current pattern can be used to distinguish them, suggesting that it can be useful for the development of devices as diagnostics tools for amyloidosislike diseasesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/30964/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52ORIGINALChargeTransportFibrous_Bezerril_2011.pdfChargeTransportFibrous_Bezerril_2011.pdfapplication/pdf258734https://repositorio.ufrn.br/bitstream/123456789/30964/1/ChargeTransportFibrous_Bezerril_2011.pdfe6522a8f82805d66a2e2d9acfe164818MD51TEXTChargeTransportFibrous_Bezerril_2011.pdf.txtChargeTransportFibrous_Bezerril_2011.pdf.txtExtracted texttext/plain16282https://repositorio.ufrn.br/bitstream/123456789/30964/3/ChargeTransportFibrous_Bezerril_2011.pdf.txt164cdf8ec61dc6e6045c161822c7c81eMD53THUMBNAILChargeTransportFibrous_Bezerril_2011.pdf.jpgChargeTransportFibrous_Bezerril_2011.pdf.jpgGenerated Thumbnailimage/jpeg1561https://repositorio.ufrn.br/bitstream/123456789/30964/4/ChargeTransportFibrous_Bezerril_2011.pdf.jpg8598d39cd4cd7939d1ff470a40cf1b7eMD54123456789/309642020-12-13 05:01:49.943oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-12-13T08:01:49Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Charge transport in fibrous/not fibrous -helical and variant peptides |
title |
Charge transport in fibrous/not fibrous -helical and variant peptides |
spellingShingle |
Charge transport in fibrous/not fibrous -helical and variant peptides Bezerril, Leonardo Mafra Charge transport Fibrous/not fibrous Helical Variant peptides |
title_short |
Charge transport in fibrous/not fibrous -helical and variant peptides |
title_full |
Charge transport in fibrous/not fibrous -helical and variant peptides |
title_fullStr |
Charge transport in fibrous/not fibrous -helical and variant peptides |
title_full_unstemmed |
Charge transport in fibrous/not fibrous -helical and variant peptides |
title_sort |
Charge transport in fibrous/not fibrous -helical and variant peptides |
author |
Bezerril, Leonardo Mafra |
author_facet |
Bezerril, Leonardo Mafra Fulco, Umberto Laino Oliveira, Jonas Ivan Nobre Corso, Gilberto Albuquerque, Eudenilson Lins de Freire, V. N. Caetano, W. S. |
author_role |
author |
author2 |
Fulco, Umberto Laino Oliveira, Jonas Ivan Nobre Corso, Gilberto Albuquerque, Eudenilson Lins de Freire, V. N. Caetano, W. S. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bezerril, Leonardo Mafra Fulco, Umberto Laino Oliveira, Jonas Ivan Nobre Corso, Gilberto Albuquerque, Eudenilson Lins de Freire, V. N. Caetano, W. S. |
dc.subject.por.fl_str_mv |
Charge transport Fibrous/not fibrous Helical Variant peptides |
topic |
Charge transport Fibrous/not fibrous Helical Variant peptides |
description |
Although differing only by the Ala→Gln substitution at the fifth or seventh position of the 3-peptide amino acid sequence Leu-Glu-Thr-Leu-Ala-Lys-Ala3, the 5Q3 variant forms fibrous assemblies more attenuated than those of the 3-peptide, while the 7Q3 variant does not form fibrils. A tight-binding transport modeling was performed to obtain their current-voltage patterns, with hopping energies of the dipeptides calculated within the density functional theory framework. Beyond the semiconductor character, we obtain that the current pattern can be used to distinguish them, suggesting that it can be useful for the development of devices as diagnostics tools for amyloidosislike diseases |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-01-31 |
dc.date.accessioned.fl_str_mv |
2020-12-11T16:23:41Z |
dc.date.available.fl_str_mv |
2020-12-11T16:23:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BEZERRIL, L. M.; FULCO, U. L.; OLIVEIRA, J. I. N.; CORSO, G.; ALBUQUERQUE, E. L.; FREIRE, V. N.; CAETANO, E. W. S.. Charge transport in fibrous/not fibrous α3-helical and (5Q,7Q)α3 variant peptides. Applied Physics Letters, [S.L.], v. 98, n. 5, p. 053702-053702, 31 jan. 2011. Disponível em: https://aip.scitation.org/doi/10.1063/1.3551713. Acesso em: 16 out. 2020. http://dx.doi.org/10.1063/1.3551713. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/30964 |
dc.identifier.issn.none.fl_str_mv |
0003-6951 1077-3118 |
dc.identifier.doi.none.fl_str_mv |
10.1063/1.3551713 |
identifier_str_mv |
BEZERRIL, L. M.; FULCO, U. L.; OLIVEIRA, J. I. N.; CORSO, G.; ALBUQUERQUE, E. L.; FREIRE, V. N.; CAETANO, E. W. S.. Charge transport in fibrous/not fibrous α3-helical and (5Q,7Q)α3 variant peptides. Applied Physics Letters, [S.L.], v. 98, n. 5, p. 053702-053702, 31 jan. 2011. Disponível em: https://aip.scitation.org/doi/10.1063/1.3551713. Acesso em: 16 out. 2020. http://dx.doi.org/10.1063/1.3551713. 0003-6951 1077-3118 10.1063/1.3551713 |
url |
https://repositorio.ufrn.br/handle/123456789/30964 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Institute of Physics |
publisher.none.fl_str_mv |
American Institute of Physics |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/30964/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/30964/1/ChargeTransportFibrous_Bezerril_2011.pdf https://repositorio.ufrn.br/bitstream/123456789/30964/3/ChargeTransportFibrous_Bezerril_2011.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/30964/4/ChargeTransportFibrous_Bezerril_2011.pdf.jpg |
bitstream.checksum.fl_str_mv |
e9597aa2854d128fd968be5edc8a28d9 e6522a8f82805d66a2e2d9acfe164818 164cdf8ec61dc6e6045c161822c7c81e 8598d39cd4cd7939d1ff470a40cf1b7e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117823072305152 |