Efeitos da administração aguda e crônica de agomelatina sobre comportamentos relacionados à ansiedade e ao pânico em ratas submetidas ao labirinto em T elevado

• Autor(a) principal: Gomes, Ana Clara da Costa Nunes
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/43138
• topic: Agomelatina; Agomelatine; Ansiedade; Anxiety; Labirinto em T elevado; Elevated T maze

Agomelatine is used for treating depression and it has been shown efficient in relieving the symptoms of anxiety. The Elevated T maze (ETM) is based on innate aversion of rodents to open and high spaces, allowing the observation of inhibitory avoidance and escape responses in the same animal. Such responses have been associated, respectively, with generalized anxiety and panic. The aim of present study was to evaluate if agomelatine administration alter anxiety and panic-like responses in female rats. Agomelatine was acutely administered at doses of 25, 50 and 75 mg/kg/2mL, and chronically administered at a dose of 50 mg/kg/2 ml for 25 days. In the latter group liver histology was evaluated. To evaluation the locomotor activity of the rats we used the open field test. The results demonstrate that both acute and chronic administration of agomelatine in females do not significantly alter the locomotion of the rats. Regarding the inhibitory avoidance response, there was no changes in this response for both acute and chronic treatments, including the analysis of rats in proestrus/estrus. A trial effect was observed, suggesting acquisition of inhibitory avoidance in all cases. A decrease in the escape response latency was observed after acute, but not chronic administration of agomelatine. Regarding hepatic histology after chronic administration, no changes were observed when compared to the control group. Data here obtained suggest a panicogenic-like effect of acute administration of agomelatine and the absence of both behavioral and hepatic toxicity effects after chronic administration in females.