Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Detalhes bibliográficos
Autor(a) principal: Silva, Vandeclécio Lira da
Data de Publicação: 2017
Outros Autores: Fonseca, André Faustino, Fonseca, Marbella M., Silva, Thayna Emília da, Coelho, Ana Carolina, Kroll, José Eduardo, Souza, Jorge Estefano Santana de, Ferreira, Beatriz Stransky, Souza, Gustavo Antônio de, Souza, Sandro José de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/29575
Resumo: Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma
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spelling Silva, Vandeclécio Lira daFonseca, André FaustinoFonseca, Marbella M.Silva, Thayna Emília daCoelho, Ana CarolinaKroll, José EduardoSouza, Jorge Estefano Santana deFerreira, Beatriz StranskySouza, Gustavo Antônio deSouza, Sandro José de2020-07-13T16:36:27Z2020-07-13T16:36:27Z2017-10-10SILVA, V.; FONSECA, A.; FONSECA, M. ; SILVA, T.; COELHO, A.; KROLL, J.; SOUZA, J.; FERREIRA, B. S.;SOUZA, G.; SOUZA, S.. Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. Oncotarget, v. 8, p. 92966-92977, 2017. Disponível em: https://www.oncotarget.com/article/21715/text/. Acesso em: 10 jul. 2020. https://doi.org/10.18632/oncotarget.217151949-2553https://repositorio.ufrn.br/jspui/handle/123456789/2957510.18632/oncotarget.21715Impact JournalsAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCancer/testisCancer antigensBiomarkersPrognosisGenome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanomaengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/29575/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/29575/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53ORIGINALGenome-wideIdentification_FERREIRA_2017.pdfGenome-wideIdentification_FERREIRA_2017.pdfArtigoapplication/pdf3993134https://repositorio.ufrn.br/bitstream/123456789/29575/1/Genome-wideIdentification_FERREIRA_2017.pdf262c3958befe1f2c05b31cda0c9a9939MD51TEXTGenome-wideIdentification_FERREIRA_2017.pdf.txtGenome-wideIdentification_FERREIRA_2017.pdf.txtExtracted texttext/plain45639https://repositorio.ufrn.br/bitstream/123456789/29575/4/Genome-wideIdentification_FERREIRA_2017.pdf.txt81230ea07aafa1517110ade9e77678bdMD54THUMBNAILGenome-wideIdentification_FERREIRA_2017.pdf.jpgGenome-wideIdentification_FERREIRA_2017.pdf.jpgGenerated Thumbnailimage/jpeg1872https://repositorio.ufrn.br/bitstream/123456789/29575/5/Genome-wideIdentification_FERREIRA_2017.pdf.jpg161e12db48aa51e8c1bab97ab72f03f5MD55123456789/295752020-07-19 04:45:25.306oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2020-07-19T07:45:25Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
title Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
spellingShingle Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
Silva, Vandeclécio Lira da
Cancer/testis
Cancer antigens
Biomarkers
Prognosis
title_short Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
title_full Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
title_fullStr Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
title_full_unstemmed Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
title_sort Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis
author Silva, Vandeclécio Lira da
author_facet Silva, Vandeclécio Lira da
Fonseca, André Faustino
Fonseca, Marbella M.
Silva, Thayna Emília da
Coelho, Ana Carolina
Kroll, José Eduardo
Souza, Jorge Estefano Santana de
Ferreira, Beatriz Stransky
Souza, Gustavo Antônio de
Souza, Sandro José de
author_role author
author2 Fonseca, André Faustino
Fonseca, Marbella M.
Silva, Thayna Emília da
Coelho, Ana Carolina
Kroll, José Eduardo
Souza, Jorge Estefano Santana de
Ferreira, Beatriz Stransky
Souza, Gustavo Antônio de
Souza, Sandro José de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Vandeclécio Lira da
Fonseca, André Faustino
Fonseca, Marbella M.
Silva, Thayna Emília da
Coelho, Ana Carolina
Kroll, José Eduardo
Souza, Jorge Estefano Santana de
Ferreira, Beatriz Stransky
Souza, Gustavo Antônio de
Souza, Sandro José de
dc.subject.por.fl_str_mv Cancer/testis
Cancer antigens
Biomarkers
Prognosis
topic Cancer/testis
Cancer antigens
Biomarkers
Prognosis
description Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma
publishDate 2017
dc.date.issued.fl_str_mv 2017-10-10
dc.date.accessioned.fl_str_mv 2020-07-13T16:36:27Z
dc.date.available.fl_str_mv 2020-07-13T16:36:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SILVA, V.; FONSECA, A.; FONSECA, M. ; SILVA, T.; COELHO, A.; KROLL, J.; SOUZA, J.; FERREIRA, B. S.;SOUZA, G.; SOUZA, S.. Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. Oncotarget, v. 8, p. 92966-92977, 2017. Disponível em: https://www.oncotarget.com/article/21715/text/. Acesso em: 10 jul. 2020. https://doi.org/10.18632/oncotarget.21715
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/jspui/handle/123456789/29575
dc.identifier.issn.none.fl_str_mv 1949-2553
dc.identifier.doi.none.fl_str_mv 10.18632/oncotarget.21715
identifier_str_mv SILVA, V.; FONSECA, A.; FONSECA, M. ; SILVA, T.; COELHO, A.; KROLL, J.; SOUZA, J.; FERREIRA, B. S.;SOUZA, G.; SOUZA, S.. Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis. Oncotarget, v. 8, p. 92966-92977, 2017. Disponível em: https://www.oncotarget.com/article/21715/text/. Acesso em: 10 jul. 2020. https://doi.org/10.18632/oncotarget.21715
1949-2553
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http://creativecommons.org/licenses/by/3.0/br/
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http://creativecommons.org/licenses/by/3.0/br/
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