A distinct class of bursting neuronswith strong gamma synchronizationand stimulus selectivity in monkey V1

• Autor(a) principal: Onorato, Irene
• Data de Publicação: 2019
• Outros Autores: Maciel, Sergio Tulio Neuenschwander, Hoy, Jennifer, Lima, Bruss, Rocha, Katia-Simone, Broggini, Ana Clara, Uran, Cem, Spyropoulos, Georgios, Klon-Lipok, Johanna, Womelsdorf, Thilo, Fries, Pascal, Niell, Cristopher, Singer, Wolf, Vinck, Martin
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/27914; https://doi.org/10.1016/j.neuron.2019.09.039
• topic: Bursting; cell class; cell type; excitatory; gamma oscillation; monkey V1; interneuron; orientation tuning

Cortical computation depends on interactions between excitatory and inhibitory neurons. The contributions of distinct neuron types to sensory processing and network synchronization in primate visual cortex remain largely undetermined. We show that in awake monkey V1, there exists a distinct cell type (››30% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates and fires in high-frequency bursts. These neurons are more stimulus selective and phase locked to 30- to 80-Hz gamma oscillations than other neuron types. Unlike other neuron types, their gamma-phase locking is highly predictive of orientation tuning. We find evidence for strong rhythmic inhibition in these neurons, suggesting that they interact with interneurons to act as excitatory pacemakers for the V1 gamma rhythm. We did not find a similar class of NW bursting neurons in L2-L4 of mouse V1. Given its properties, this class of NW bursting neurons should be pivotal for the encoding and transmission of stimulus information.