Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/24684 |
Resumo: | The cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Ab) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion of Ab, which corresponds to the moderate or severe impairments of the disease. In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats. Ab infusion induced a deficit in the performance (increased latency and distance traveled to reach the target compared to saline group). In addition, a significant association between treatment and search strategy in the retrieval trial was found: Ab group preferred the non-spatial search strategy, while saline group preferred the spatial search. In conclusion, the protocol of Ab infusion used here induced a subtle cognitive deficit that was specific to spatial aspects. Indeed, animals under Ab treatment still showed retrieval, but using non-spatial strategies. We suggest that this approach is potentially useful to the study of the initial memory deficits in early AD. |
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Macêdo, Priscila TavaresAquino, Antônio C. Q.Meurer, Ywlliane S. R.Brandão, Luiz E. M.Campêlo, Clarissa L. C.Lima, Ramon H.Costa, Marcos RomualdoRibeiro, Alessandra M.Silva, Regina H.2018-01-31T14:31:47Z2018-01-31T14:31:47Z2018-01-30https://repositorio.ufrn.br/jspui/handle/123456789/246840.3389/fnagi.2018.00018engneurodegenerative diseaseb-amyloid peptidebarnes mazenavigationstrategySubtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Ab) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion of Ab, which corresponds to the moderate or severe impairments of the disease. In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats. Ab infusion induced a deficit in the performance (increased latency and distance traveled to reach the target compared to saline group). In addition, a significant association between treatment and search strategy in the retrieval trial was found: Ab group preferred the non-spatial search strategy, while saline group preferred the spatial search. In conclusion, the protocol of Ab infusion used here induced a subtle cognitive deficit that was specific to spatial aspects. Indeed, animals under Ab treatment still showed retrieval, but using non-spatial strategies. We suggest that this approach is potentially useful to the study of the initial memory deficits in early AD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNTEXTMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdf.txtMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdf.txtExtracted texttext/plain46957https://repositorio.ufrn.br/bitstream/123456789/24684/3/MarcosCosta_ICe_2018_Subtle%20Alterations%20in%20Spatial%20Memory.pdf.txt8e4230b909cdc4791656d7f33f4e6950MD53THUMBNAILMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdf.jpgMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdf.jpgIM Thumbnailimage/jpeg7607https://repositorio.ufrn.br/bitstream/123456789/24684/4/MarcosCosta_ICe_2018_Subtle%20Alterations%20in%20Spatial%20Memory.pdf.jpg2bee57cfb4a7d7f8ed9cf99ec0fd7e3aMD54ORIGINALMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdfMarcosCosta_ICe_2018_Subtle Alterations in Spatial Memory.pdfapplication/pdf1462990https://repositorio.ufrn.br/bitstream/123456789/24684/1/MarcosCosta_ICe_2018_Subtle%20Alterations%20in%20Spatial%20Memory.pdf9598d55e1b75de83c48d7a7609968727MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/24684/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/246842021-07-09 17:37:41.345oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-09T20:37:41Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
title |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
spellingShingle |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats Macêdo, Priscila Tavares neurodegenerative disease b-amyloid peptide barnes maze navigation strategy |
title_short |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
title_full |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
title_fullStr |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
title_full_unstemmed |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
title_sort |
Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats |
author |
Macêdo, Priscila Tavares |
author_facet |
Macêdo, Priscila Tavares Aquino, Antônio C. Q. Meurer, Ywlliane S. R. Brandão, Luiz E. M. Campêlo, Clarissa L. C. Lima, Ramon H. Costa, Marcos Romualdo Ribeiro, Alessandra M. Silva, Regina H. |
author_role |
author |
author2 |
Aquino, Antônio C. Q. Meurer, Ywlliane S. R. Brandão, Luiz E. M. Campêlo, Clarissa L. C. Lima, Ramon H. Costa, Marcos Romualdo Ribeiro, Alessandra M. Silva, Regina H. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Macêdo, Priscila Tavares Aquino, Antônio C. Q. Meurer, Ywlliane S. R. Brandão, Luiz E. M. Campêlo, Clarissa L. C. Lima, Ramon H. Costa, Marcos Romualdo Ribeiro, Alessandra M. Silva, Regina H. |
dc.subject.por.fl_str_mv |
neurodegenerative disease b-amyloid peptide barnes maze navigation strategy |
topic |
neurodegenerative disease b-amyloid peptide barnes maze navigation strategy |
description |
The cause of Alzheimer’s disease (AD) remains uncertain. The accumulation of amyloid peptides (Ab) is the main pathophysiological hallmark of the disease. Spatial deficit is an important initial sign of AD, while other types of memory impairments that appear in later stages. The Barnes maze allows the detection of subtle alterations in spatial search by the analysis of use of different strategies. Previous findings showed a general performance deficit in this task following long-term (35 days) infusion of Ab, which corresponds to the moderate or severe impairments of the disease. In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats. Ab infusion induced a deficit in the performance (increased latency and distance traveled to reach the target compared to saline group). In addition, a significant association between treatment and search strategy in the retrieval trial was found: Ab group preferred the non-spatial search strategy, while saline group preferred the spatial search. In conclusion, the protocol of Ab infusion used here induced a subtle cognitive deficit that was specific to spatial aspects. Indeed, animals under Ab treatment still showed retrieval, but using non-spatial strategies. We suggest that this approach is potentially useful to the study of the initial memory deficits in early AD. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-01-31T14:31:47Z |
dc.date.available.fl_str_mv |
2018-01-31T14:31:47Z |
dc.date.issued.fl_str_mv |
2018-01-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/24684 |
dc.identifier.doi.none.fl_str_mv |
0.3389/fnagi.2018.00018 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/24684 |
identifier_str_mv |
0.3389/fnagi.2018.00018 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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