PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study

• Autor(a) principal: Oliveira, Mayara Mota de
• Data de Publicação: 2021
• Outros Autores: Peterle, Gabriela Tonini, Couto, Cinthia Vidal Monteiro da Silva, Maia, Lucas de Lima, Kühl, Andre, Santos, Joaquim Gasparini dos, Moysés, Raquel Ajub, Trivilin, Leonardo Oliveira, Borçoi, Aline Ribeiro, Archanjo, Anderson Barros, Assis, Arícia Leone Evangelista Monteiro de, Nunes, Fábio Daumas, Santos, Marcelo dos, Silva, Adriana Madeira Álvares da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/45745
• topic: PAI-1; Oral squamous cell carcinoma; Lymph node; Prognostic marker

Introduction: Immune cells contribute with mediators in the protein expression profile of the tumor microenvi ronment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory con ditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Methods: Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Results: Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI =1.54–48.08; p = 0.014). Conclusion: Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.