Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/50970 |
Resumo: | Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis. |
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Magalhães, Paulo André FreireMiranda, Cleine Aglacy NunesLima, Érika GalvãoMoizéis, Raíza Nara CunhaLima, Diego Breno Soares deCobucci, Ricardo Ney OliveiraFernandes, Thales Allyrio Araújo de MedeirosAzevedo, Jenner Chrystian Veríssimo deAzevedo, Paulo Roberto Medeiros deAraújo, Josélio Maria Galvão deFernandes, José Veríssimo2023-01-16T22:04:14Z2023-01-16T22:04:14Z2014-10MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017.https://repositorio.ufrn.br/handle/123456789/5097010.1007/s00404-014-3514-zSpringerChlamydia trachomatisHuman papillomavirusRisk factorsGenital tract infectionGenital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePurpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALGenitalTractInfectionWithChlamydia_2014.pdfGenitalTractInfectionWithChlamydia_2014.pdfapplication/pdf215315https://repositorio.ufrn.br/bitstream/123456789/50970/1/GenitalTractInfectionWithChlamydia_2014.pdff6ed70a486be93a315159add6c2fb7bbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/50970/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/509702023-01-16 19:04:15.221oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-01-16T22:04:15Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
title |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
spellingShingle |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil Magalhães, Paulo André Freire Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection |
title_short |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
title_full |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
title_fullStr |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
title_full_unstemmed |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
title_sort |
Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil |
author |
Magalhães, Paulo André Freire |
author_facet |
Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo |
author_role |
author |
author2 |
Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães, Paulo André Freire Miranda, Cleine Aglacy Nunes Lima, Érika Galvão Moizéis, Raíza Nara Cunha Lima, Diego Breno Soares de Cobucci, Ricardo Ney Oliveira Fernandes, Thales Allyrio Araújo de Medeiros Azevedo, Jenner Chrystian Veríssimo de Azevedo, Paulo Roberto Medeiros de Araújo, Josélio Maria Galvão de Fernandes, José Veríssimo |
dc.subject.por.fl_str_mv |
Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection |
topic |
Chlamydia trachomatis Human papillomavirus Risk factors Genital tract infection |
description |
Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-10 |
dc.date.accessioned.fl_str_mv |
2023-01-16T22:04:14Z |
dc.date.available.fl_str_mv |
2023-01-16T22:04:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/50970 |
dc.identifier.doi.none.fl_str_mv |
10.1007/s00404-014-3514-z |
identifier_str_mv |
MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017. 10.1007/s00404-014-3514-z |
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Springer |
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Springer |
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