Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil

Detalhes bibliográficos
Autor(a) principal: Magalhães, Paulo André Freire
Data de Publicação: 2014
Outros Autores: Miranda, Cleine Aglacy Nunes, Lima, Érika Galvão, Moizéis, Raíza Nara Cunha, Lima, Diego Breno Soares de, Cobucci, Ricardo Ney Oliveira, Fernandes, Thales Allyrio Araújo de Medeiros, Azevedo, Jenner Chrystian Veríssimo de, Azevedo, Paulo Roberto Medeiros de, Araújo, Josélio Maria Galvão de, Fernandes, José Veríssimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/50970
Resumo: Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis.
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spelling Magalhães, Paulo André FreireMiranda, Cleine Aglacy NunesLima, Érika GalvãoMoizéis, Raíza Nara CunhaLima, Diego Breno Soares deCobucci, Ricardo Ney OliveiraFernandes, Thales Allyrio Araújo de MedeirosAzevedo, Jenner Chrystian Veríssimo deAzevedo, Paulo Roberto Medeiros deAraújo, Josélio Maria Galvão deFernandes, José Veríssimo2023-01-16T22:04:14Z2023-01-16T22:04:14Z2014-10MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017.https://repositorio.ufrn.br/handle/123456789/5097010.1007/s00404-014-3514-zSpringerChlamydia trachomatisHuman papillomavirusRisk factorsGenital tract infectionGenital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePurpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALGenitalTractInfectionWithChlamydia_2014.pdfGenitalTractInfectionWithChlamydia_2014.pdfapplication/pdf215315https://repositorio.ufrn.br/bitstream/123456789/50970/1/GenitalTractInfectionWithChlamydia_2014.pdff6ed70a486be93a315159add6c2fb7bbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/50970/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/509702023-01-16 19:04:15.221oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-01-16T22:04:15Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
spellingShingle Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
Magalhães, Paulo André Freire
Chlamydia trachomatis
Human papillomavirus
Risk factors
Genital tract infection
title_short Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_full Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_fullStr Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_full_unstemmed Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
title_sort Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil
author Magalhães, Paulo André Freire
author_facet Magalhães, Paulo André Freire
Miranda, Cleine Aglacy Nunes
Lima, Érika Galvão
Moizéis, Raíza Nara Cunha
Lima, Diego Breno Soares de
Cobucci, Ricardo Ney Oliveira
Fernandes, Thales Allyrio Araújo de Medeiros
Azevedo, Jenner Chrystian Veríssimo de
Azevedo, Paulo Roberto Medeiros de
Araújo, Josélio Maria Galvão de
Fernandes, José Veríssimo
author_role author
author2 Miranda, Cleine Aglacy Nunes
Lima, Érika Galvão
Moizéis, Raíza Nara Cunha
Lima, Diego Breno Soares de
Cobucci, Ricardo Ney Oliveira
Fernandes, Thales Allyrio Araújo de Medeiros
Azevedo, Jenner Chrystian Veríssimo de
Azevedo, Paulo Roberto Medeiros de
Araújo, Josélio Maria Galvão de
Fernandes, José Veríssimo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magalhães, Paulo André Freire
Miranda, Cleine Aglacy Nunes
Lima, Érika Galvão
Moizéis, Raíza Nara Cunha
Lima, Diego Breno Soares de
Cobucci, Ricardo Ney Oliveira
Fernandes, Thales Allyrio Araújo de Medeiros
Azevedo, Jenner Chrystian Veríssimo de
Azevedo, Paulo Roberto Medeiros de
Araújo, Josélio Maria Galvão de
Fernandes, José Veríssimo
dc.subject.por.fl_str_mv Chlamydia trachomatis
Human papillomavirus
Risk factors
Genital tract infection
topic Chlamydia trachomatis
Human papillomavirus
Risk factors
Genital tract infection
description Purpose This cross-sectional study aimed to estimate the prevalence of Chlamydia trachomatis (CT) infection alone and in combination with human papillomavirus (HPV). Furthermore, the study investigates whether the CT infection increases the risk of contracting HPV and whether the presence of both pathogens is associated with a higher prevalence of cervical lesions. Methods Cervical samples of 1,134 asymptomatic women enrolled in a screening program for cervical cancer were analyzed. Two cervical specimens were collected from each patient, one for cytologic examination and the other for detection of CT by polymerase chain reaction (PCR), using a primer pair which amplifies a specific sequence of the DNA plasmid. Results The overall prevalence rate infection was 10.9 %, being 10 % in the women with normal cytology, 13.8 % in those with atypical squamous cells of undetermined significance (ASC-US), and 25 % with low-grade squamous intraepithelial lesion (LSIL). The infection by CT did not increase the risk of acquiring HPV infection. The higher prevalence of LSIL in women co-infected with HPV and CT is possibly due to HPV. Conclusion CT infection was more prevalent in younger women aged up to 32 years, who had an early onset of reproductive activity and a history of having had multiple sexual partners lifelong may be at a greater risk of acquiring infection of the genital tract by C. trachomatis.
publishDate 2014
dc.date.issued.fl_str_mv 2014-10
dc.date.accessioned.fl_str_mv 2023-01-16T22:04:14Z
dc.date.available.fl_str_mv 2023-01-16T22:04:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/50970
dc.identifier.doi.none.fl_str_mv 10.1007/s00404-014-3514-z
identifier_str_mv MAGALHÃES, Paulo André F. et al. Genital tract infection with Chlamydia trachomatis in women attended at a cervical cancer screening program in Northeastern from Brazil. Archives of Gynecology and Obstetrics, v. 2015, p. 1095-1102, 2014. Disponível em: https://link.springer.com/article/10.1007%2Fs00404-014-3514-z. Acesso em: 08 dez. 2017.
10.1007/s00404-014-3514-z
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