Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão

Detalhes bibliográficos
Autor(a) principal: Silva, Lucas Gabriel de Medeiros da
Data de Publicação: 2022
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/48627
Resumo: CNPq
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spelling Silva, Lucas Gabriel de Medeiros dahttp://lattes.cnpq.br/0087544261520109http://lattes.cnpq.br/4061809277935577Oliveira, Verônica da Silvahttp://lattes.cnpq.br/3459683395706868Lima, Ádley Antonini Neves dehttp://lattes.cnpq.br/4061809277935577Oliveira, Verônica da Silvahttp://lattes.cnpq.br/3459683395706868Nogueira, Fernando Henrique Andradehttp://lattes.cnpq.br/3818421971151621Lima, Waldenice de Alencar Moraishttp://lattes.cnpq.br/2575667613995470Lima, Ádley Antonini Neves de2022-07-21T17:57:51Z2022-07-21T17:57:51Z2022-06-30SILVA, Lucas Gabriel de Medeiros da. Evaluation of Chitosan-Based Dressings For Cutaneous Wounds: a Review. 2022. 36f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.https://repositorio.ufrn.br/handle/123456789/48627CNPqCAPESBiopolymeric dressings are increasingly being used as an effective alternative for wound healing, since they may present multifunctional properties such as biocompatibility, low toxicity, flexibility, permeability, easy removal and many others. Although there are several biopolymers for wound healing purposes, one of the most prominent is chitosan, known it for characteristics and potential for action, such as anti-inflammatory and antimicrobial. In this context, this article aimed to investigate in vitro and in vivo studies of chitosan dressings both isolated and in associations with other components. In in vitro studies, it was possible to evaluate parameters such as biocompatibility, antimicrobial activity and release assays, confirming positive results for chitosan dressings associated with other components. In in vivo studies, it was possible to evaluate the healing potential at macroscopic and histological levels. As main results, it was observed that the wounds showed complete healing rate between 9 and 14 days, complete re-epithelialization and collagen formation. Thus, this work revealed that it is possible to develop biopolymeric chitosan dressings incorporated to other polymers or active pharmaceutical inputs, since the results are extremely satisfactory, making it a promising strategy for clinical studies in the treatment of skin lesions.Universidade Federal do Rio Grande do NorteFarmáciaUFRNBrasilDepartamento de FarmáciaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccesspolymeric dressingsskin woundschitosanbiological assayswound healingcharacterization techniquesAvaliação dos curativos à base de quitosana para feridas cutâneas: uma revisãoEvaluation of chitosan-based dressings for cutaneous wounds: a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALTCC LUCAS - VERSÃO FINAL.pdfTCC LUCAS - VERSÃO FINAL.pdfTCC LUCAS - Evaluation of Chitosan-based Dressings for Cutaneous Wounds: a reviewapplication/pdf813783https://repositorio.ufrn.br/bitstream/123456789/48627/1/TCC%20LUCAS%20-%20VERS%c3%83O%20FINAL.pdf9f7107c0398b464b0a7a34f5ead46403MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/48627/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8811https://repositorio.ufrn.br/bitstream/123456789/48627/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52123456789/486272022-07-21 14:57:52.149oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-07-21T17:57:52Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
dc.title.alternative.pt_BR.fl_str_mv Evaluation of chitosan-based dressings for cutaneous wounds: a review
title Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
spellingShingle Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
Silva, Lucas Gabriel de Medeiros da
polymeric dressings
skin wounds
chitosan
biological assays
wound healing
characterization techniques
title_short Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
title_full Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
title_fullStr Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
title_full_unstemmed Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
title_sort Avaliação dos curativos à base de quitosana para feridas cutâneas: uma revisão
author Silva, Lucas Gabriel de Medeiros da
author_facet Silva, Lucas Gabriel de Medeiros da
author_role author
dc.contributor.authorLattes.pt_BR.fl_str_mv http://lattes.cnpq.br/0087544261520109
dc.contributor.advisorLattes.pt_BR.fl_str_mv http://lattes.cnpq.br/4061809277935577
dc.contributor.referees1.none.fl_str_mv Lima, Ádley Antonini Neves de
dc.contributor.referees1Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/4061809277935577
dc.contributor.referees2.none.fl_str_mv Oliveira, Verônica da Silva
dc.contributor.referees2Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/3459683395706868
dc.contributor.referees3.none.fl_str_mv Nogueira, Fernando Henrique Andrade
dc.contributor.referees3Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/3818421971151621
dc.contributor.referees4.none.fl_str_mv Lima, Waldenice de Alencar Morais
dc.contributor.referees4Lattes.pt_BR.fl_str_mv http://lattes.cnpq.br/2575667613995470
dc.contributor.author.fl_str_mv Silva, Lucas Gabriel de Medeiros da
dc.contributor.advisor-co1.fl_str_mv Oliveira, Verônica da Silva
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3459683395706868
dc.contributor.advisor1.fl_str_mv Lima, Ádley Antonini Neves de
contributor_str_mv Oliveira, Verônica da Silva
Lima, Ádley Antonini Neves de
dc.subject.por.fl_str_mv polymeric dressings
skin wounds
chitosan
biological assays
wound healing
characterization techniques
topic polymeric dressings
skin wounds
chitosan
biological assays
wound healing
characterization techniques
description CNPq
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-21T17:57:51Z
dc.date.available.fl_str_mv 2022-07-21T17:57:51Z
dc.date.issued.fl_str_mv 2022-06-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Lucas Gabriel de Medeiros da. Evaluation of Chitosan-Based Dressings For Cutaneous Wounds: a Review. 2022. 36f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/48627
identifier_str_mv SILVA, Lucas Gabriel de Medeiros da. Evaluation of Chitosan-Based Dressings For Cutaneous Wounds: a Review. 2022. 36f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2022.
url https://repositorio.ufrn.br/handle/123456789/48627
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.program.fl_str_mv Farmácia
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Departamento de Farmácia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
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