Association of Interleukin-17A/RA and HLA-G polymorphisms with Gestational Diabetes Mellitus

• Autor(a) principal: Lucas, Cecília Rodrigues
• Data de Publicação: 2019
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/35735
• topic: 2.11.02.00-7 Imunologia Celular 2.11.03.00-3 Imunogenética 2.11.04.00-0 Imunologia Aplicada; Gestational diabetes; Polymorphism.; Diagnosis

Gestational Diabetes Mellitus (GDM) is a special type of diabetes that has been defined as any of glucose intolerance with onset or first recognition during pregnancy. The increasing of pregnancies complicated by GDM has been of great warning to the scientific community, as its pathophysiology is not well described and it has been related to severe pregnancy complications. The aim of this study is to evaluate the role of rs2275913, rs4819554 and rs66554220 polymorphisms in pregnancy complicated by GDM. The study comprised 79 patients with pregnancy complicated by GDM, as well as 81 healthy pregnant women (control group) from a High Risk Prenatal Outpatient Clinic. Personal data from the subjects were collected by forms, and polymorphisms of rs2275913, rs4819554 and rs66554220 were determined from subjects biological material by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Fasting glucose and Body Mass Index (BMI) were significant higher in GDM group than in control group (p <0.05; p = 0.002, respectively). Obesity and overweight, and high BMI were significant when associated with GDM diagnosis (p <0.05, both). IL-17A *rs2275913* (A/A) was associated with an increased likelihood of GDM diagnosis (OR = 5.22; 95% CI 1.08-25,29; p = 0.040), and we found no statistical significance to rs66554220 polymorphism, being important to continue further research.