The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/19082 |
Resumo: | The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (DMN), a set of brain regions more active during rest than during the execution of a goal-directed task. Here we used fMRI technique to inspect the DMN during the psychedelic state induced by Ayahuasca in ten experienced subjects. Ayahuasca is a potion traditionally used by Amazonian Amerindians composed by a mixture of compounds that increase monoaminergic transmission. In particular, we examined whether Ayahuasca changes the activity and connectivity of the DMN and the connection between the DMN and the task-positive network (TPN). Ayahuasca caused a significant decrease in activity through most parts of the DMN, including its most consistent hubs: the Posterior Cingulate Cortex (PCC)/Precuneus and the medial Prefrontal Cortex (mPFC). Functional connectivity within the PCC/Precuneus decreased after Ayahuasca intake. No significant change was observed in the DMN-TPN orthogonality. Altogether, our results support the notion that the altered state of consciousness induced by Ayahuasca, like those induced by psilocybin (another serotonergic psychedelic), meditation and sleep, is linked to the modulation of the activity and the connectivity of the DMN. |
id |
UFRN_3f187d4a2aeb4b471cbce78930dabd9b |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/19082 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Palhano-Fontes, FernandaAndrade, Katia C.Tofoli, Luis F.Santos, Antonio C.Crippa, Jose Alexandre S.Hallak, Jaime E. C.Ribeiro, Sidarta Tollendal GomesAraújo, Dráulio Barros de2015-06-16T14:50:33Z2015-06-16T14:50:33Z2015-02-18Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JAS, Hallak JEC, et al. (2015) The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network. PLoS ONE 10(2): e0118143. doi:10.1371/journal.pone.01181431932-6203https://repositorio.ufrn.br/jspui/handle/123456789/19082The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (DMN), a set of brain regions more active during rest than during the execution of a goal-directed task. Here we used fMRI technique to inspect the DMN during the psychedelic state induced by Ayahuasca in ten experienced subjects. Ayahuasca is a potion traditionally used by Amazonian Amerindians composed by a mixture of compounds that increase monoaminergic transmission. In particular, we examined whether Ayahuasca changes the activity and connectivity of the DMN and the connection between the DMN and the task-positive network (TPN). Ayahuasca caused a significant decrease in activity through most parts of the DMN, including its most consistent hubs: the Posterior Cingulate Cortex (PCC)/Precuneus and the medial Prefrontal Cortex (mPFC). Functional connectivity within the PCC/Precuneus decreased after Ayahuasca intake. No significant change was observed in the DMN-TPN orthogonality. Altogether, our results support the notion that the altered state of consciousness induced by Ayahuasca, like those induced by psilocybin (another serotonergic psychedelic), meditation and sleep, is linked to the modulation of the activity and the connectivity of the DMN.The Brazilian Federal Agencies: CNPq, CAPES; FINEP; The Sao Paulo State financial agency (FAPESP).Plos OneAyahuascaDefault Mode NetworkfMRIThe Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Networkinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81563https://repositorio.ufrn.br/bitstream/123456789/19082/2/license.txt2fca3d993fd069474a9dfb5156c39499MD52ORIGINALFernandaPalhano_ICE_The Psychedelic_2015.pdfFernandaPalhano_ICE_The Psychedelic_2015.pdfArtigo completoapplication/pdf949303https://repositorio.ufrn.br/bitstream/123456789/19082/1/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf09158c645818fed9f481f779df31f832MD51TEXTFernandaPalhano_ICE_The Psychedelic_2015.pdf.txtFernandaPalhano_ICE_The Psychedelic_2015.pdf.txtExtracted texttext/plain45571https://repositorio.ufrn.br/bitstream/123456789/19082/7/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf.txt49657e5a70d9c46137ef41e81198131dMD57THUMBNAILFernandaPalhano_ICE_The Psychedelic_2015.pdf.jpgFernandaPalhano_ICE_The Psychedelic_2015.pdf.jpgIM Thumbnailimage/jpeg11653https://repositorio.ufrn.br/bitstream/123456789/19082/8/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf.jpg57f0503a8b2018eb41d117025a62bd71MD58123456789/190822021-07-10 19:11:47.519oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-07-10T22:11:47Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
title |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
spellingShingle |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network Palhano-Fontes, Fernanda Ayahuasca Default Mode Network fMRI |
title_short |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
title_full |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
title_fullStr |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
title_full_unstemmed |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
title_sort |
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network |
author |
Palhano-Fontes, Fernanda |
author_facet |
Palhano-Fontes, Fernanda Andrade, Katia C. Tofoli, Luis F. Santos, Antonio C. Crippa, Jose Alexandre S. Hallak, Jaime E. C. Ribeiro, Sidarta Tollendal Gomes Araújo, Dráulio Barros de |
author_role |
author |
author2 |
Andrade, Katia C. Tofoli, Luis F. Santos, Antonio C. Crippa, Jose Alexandre S. Hallak, Jaime E. C. Ribeiro, Sidarta Tollendal Gomes Araújo, Dráulio Barros de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Palhano-Fontes, Fernanda Andrade, Katia C. Tofoli, Luis F. Santos, Antonio C. Crippa, Jose Alexandre S. Hallak, Jaime E. C. Ribeiro, Sidarta Tollendal Gomes Araújo, Dráulio Barros de |
dc.subject.por.fl_str_mv |
Ayahuasca Default Mode Network fMRI |
topic |
Ayahuasca Default Mode Network fMRI |
description |
The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (DMN), a set of brain regions more active during rest than during the execution of a goal-directed task. Here we used fMRI technique to inspect the DMN during the psychedelic state induced by Ayahuasca in ten experienced subjects. Ayahuasca is a potion traditionally used by Amazonian Amerindians composed by a mixture of compounds that increase monoaminergic transmission. In particular, we examined whether Ayahuasca changes the activity and connectivity of the DMN and the connection between the DMN and the task-positive network (TPN). Ayahuasca caused a significant decrease in activity through most parts of the DMN, including its most consistent hubs: the Posterior Cingulate Cortex (PCC)/Precuneus and the medial Prefrontal Cortex (mPFC). Functional connectivity within the PCC/Precuneus decreased after Ayahuasca intake. No significant change was observed in the DMN-TPN orthogonality. Altogether, our results support the notion that the altered state of consciousness induced by Ayahuasca, like those induced by psilocybin (another serotonergic psychedelic), meditation and sleep, is linked to the modulation of the activity and the connectivity of the DMN. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-06-16T14:50:33Z |
dc.date.available.fl_str_mv |
2015-06-16T14:50:33Z |
dc.date.issued.fl_str_mv |
2015-02-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JAS, Hallak JEC, et al. (2015) The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network. PLoS ONE 10(2): e0118143. doi:10.1371/journal.pone.0118143 |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/19082 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
identifier_str_mv |
Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JAS, Hallak JEC, et al. (2015) The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network. PLoS ONE 10(2): e0118143. doi:10.1371/journal.pone.0118143 1932-6203 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/19082 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Plos One |
publisher.none.fl_str_mv |
Plos One |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
bitstream.url.fl_str_mv |
https://repositorio.ufrn.br/bitstream/123456789/19082/2/license.txt https://repositorio.ufrn.br/bitstream/123456789/19082/1/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf https://repositorio.ufrn.br/bitstream/123456789/19082/7/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf.txt https://repositorio.ufrn.br/bitstream/123456789/19082/8/FernandaPalhano_ICE_The%20Psychedelic_2015.pdf.jpg |
bitstream.checksum.fl_str_mv |
2fca3d993fd069474a9dfb5156c39499 09158c645818fed9f481f779df31f832 49657e5a70d9c46137ef41e81198131d 57f0503a8b2018eb41d117025a62bd71 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117598011195392 |