Minocycline treatment reduces white matter damage after excitotoxic striatal injury

Detalhes bibliográficos
Autor(a) principal: Guimarães, Joanilson S.
Data de Publicação: 2010
Outros Autores: Freire, Marco Aurelio M., Lima, Rafael R., Picanço-Diniz, Cristovam W., Pereira, Antonio, Gomes-Leal, Walace
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/23119
Resumo: We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon.
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spelling Guimarães, Joanilson S.Freire, Marco Aurelio M.Lima, Rafael R.Picanço-Diniz, Cristovam W.Pereira, AntonioGomes-Leal, Walace2017-05-26T15:00:54Z2017-05-26T15:00:54Z20100006-8993https://repositorio.ufrn.br/jspui/handle/123456789/23119engExcitotoxicityNeurodegenerationOligodendrocyteMyelinWhite matterStriatumMinocycline treatment reduces white matter damage after excitotoxic striatal injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWe investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALminocycline treatment.pdfminocycline treatment.pdfArtigo completoapplication/pdf3164561https://repositorio.ufrn.br/bitstream/123456789/23119/1/minocycline%20treatment.pdfae1b2e5693701e07e8e9bb15cc6545bfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/23119/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTminocycline treatment.pdf.txtminocycline treatment.pdf.txtExtracted texttext/plain42248https://repositorio.ufrn.br/bitstream/123456789/23119/5/minocycline%20treatment.pdf.txt92e5637749968559f495ea5896167118MD55THUMBNAILminocycline treatment.pdf.jpgminocycline treatment.pdf.jpgIM Thumbnailimage/jpeg8340https://repositorio.ufrn.br/bitstream/123456789/23119/6/minocycline%20treatment.pdf.jpgf536d43af5fb5b867f8c45f02bf3786cMD56123456789/231192017-11-04 00:09:59.341oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2017-11-04T03:09:59Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Minocycline treatment reduces white matter damage after excitotoxic striatal injury
title Minocycline treatment reduces white matter damage after excitotoxic striatal injury
spellingShingle Minocycline treatment reduces white matter damage after excitotoxic striatal injury
Guimarães, Joanilson S.
Excitotoxicity
Neurodegeneration
Oligodendrocyte
Myelin
White matter
Striatum
title_short Minocycline treatment reduces white matter damage after excitotoxic striatal injury
title_full Minocycline treatment reduces white matter damage after excitotoxic striatal injury
title_fullStr Minocycline treatment reduces white matter damage after excitotoxic striatal injury
title_full_unstemmed Minocycline treatment reduces white matter damage after excitotoxic striatal injury
title_sort Minocycline treatment reduces white matter damage after excitotoxic striatal injury
author Guimarães, Joanilson S.
author_facet Guimarães, Joanilson S.
Freire, Marco Aurelio M.
Lima, Rafael R.
Picanço-Diniz, Cristovam W.
Pereira, Antonio
Gomes-Leal, Walace
author_role author
author2 Freire, Marco Aurelio M.
Lima, Rafael R.
Picanço-Diniz, Cristovam W.
Pereira, Antonio
Gomes-Leal, Walace
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Joanilson S.
Freire, Marco Aurelio M.
Lima, Rafael R.
Picanço-Diniz, Cristovam W.
Pereira, Antonio
Gomes-Leal, Walace
dc.subject.por.fl_str_mv Excitotoxicity
Neurodegeneration
Oligodendrocyte
Myelin
White matter
Striatum
topic Excitotoxicity
Neurodegeneration
Oligodendrocyte
Myelin
White matter
Striatum
description We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-05-26T15:00:54Z
dc.date.available.fl_str_mv 2017-05-26T15:00:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 0006-8993
identifier_str_mv 0006-8993
url https://repositorio.ufrn.br/jspui/handle/123456789/23119
dc.language.iso.fl_str_mv eng
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